Insertion and deletion evolution reflects antibiotics selection pressure in a Mycobacterium tuberculosis outbreak

In genome evolution, genetic variants are the source of diversity, which natural selection acts upon. Treatment of human tuberculosis (TB) induces a strong selection pressure for the emergence of antibiotic resistance-conferring variants in the infecting Mycobacterium tuberculosis (MTB) strains. MTB...

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Veröffentlicht in:	PLoS pathogens 2020-09, Vol.16 (9), p.e1008357
Hauptverfasser:	Godfroid, Maxime, Dagan, Tal, Merker, Matthias, Kohl, Thomas A, Diel, Roland, Maurer, Florian P, Niemann, Stefan, Kupczok, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Antitubercular Agents - pharmacology Biology and Life Sciences Causes of Computer and Information Sciences Disease Outbreaks - prevention & control Drug resistance Epidemics Epistasis Evolution Evolution, Molecular Genes Genetic aspects Genetic diversity Genetic engineering Genetic variance Genetic variation Genome - genetics Genomes Genomics Germany Health aspects Humans Infections Insertion Medicine and Health Sciences Microbial drug resistance Multidrug resistance Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - pathogenicity Natural selection Outbreaks RNA polymerase Selection, Genetic Tuberculosis Tuberculosis - genetics
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