Adjuvanted HIV-1 vaccine promotes antibody-dependent phagocytic responses and protects against heterologous SHIV challenge

To augment HIV-1 pox-protein vaccine immunogenicity using a next generation adjuvant, a prime-boost strategy of recombinant modified vaccinia virus Ankara and multimeric Env gp145 was evaluated in macaques with either aluminum (alum) or a novel liposomal monophosphoryl lipid A (MPLA) formulation ads...

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Veröffentlicht in:	PLoS pathogens 2020-09, Vol.16 (9), p.e1008764-e1008764
Hauptverfasser:	Om, Kier, Paquin-Proulx, Dominic, Montero, Maria, Peachman, Kristina, Shen, Xiaoying, Wieczorek, Lindsay, Beck, Zoltan, Weiner, Joshua A, Kim, Dohoon, Li, Yifan, Mdluli, Thembi, Shubin, Zhanna, Bryant, Christopher, Sharma, Vishakha, Tokarev, Andrey, Dawson, Peter, White, Yohann, Appelbe, Oliver, Klatt, Nichole R, Tovanabutra, Sodsai, Estes, Jacob D, Matyas, Gary R, Ferrari, Guido, Alving, Carl R, Tomaras, Georgia D, Ackerman, Margaret E, Michael, Nelson L, Robb, Merlin L, Polonis, Victoria, Rolland, Morgane, Eller, Michael A, Rao, Mangala, Bolton, Diane L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant drugs Adjuvants Adjuvants, Immunologic - administration & dosage Adolescent Adult AIDS vaccines Alum Aluminum Animals Antibodies Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antibody Formation - immunology Biology and life sciences Composition Double-Blind Method Engineering schools Female Gender aspects Genetic aspects Glycoprotein gp120 Health aspects Health risks HIV HIV Antibodies - immunology HIV Infections - immunology HIV Infections - prevention & control HIV Infections - virology HIV-1 - drug effects HIV-1 - immunology Human immunodeficiency virus Humans Immune response Immunogenicity Infections Lipid A Lipids Macaca mulatta Male Males Medical research Medicine Medicine and health sciences Middle Aged Military medicine Monocytes Monophosphoryl lipid A Mucosa People and Places Phagocytes Pharmaceutical sciences Proteins SAIDS Vaccines - immunology SAIDS Vaccines - therapeutic use Sex differences Sexually transmitted diseases Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - prevention & control Simian Acquired Immunodeficiency Syndrome - virology Simian Immunodeficiency Virus - drug effects Simian Immunodeficiency Virus - immunology STD Supervision Vaccination Vaccine efficacy Vaccines Viral proteins Viruses Young Adult
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