Comparative assessment of multiple COVID-19 serological technologies supports continued evaluation of point-of-care lateral flow assays in hospital and community healthcare settings

There is a clear requirement for an accurate SARS-CoV-2 antibody test, both as a complement to existing diagnostic capabilities and for determining community seroprevalence. We therefore evaluated the performance of a variety of antibody testing technologies and their potential use as diagnostic too...

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Veröffentlicht in:	PLoS pathogens 2020-09, Vol.16 (9), p.e1008817-e1008817
Hauptverfasser:	Pickering, Suzanne, Betancor, Gilberto, Galão, Rui Pedro, Merrick, Blair, Signell, Adrian W, Wilson, Harry D, Kia Ik, Mark Tan, Seow, Jeffrey, Graham, Carl, Acors, Sam, Kouphou, Neophytos, Steel, Kathryn J A, Hemmings, Oliver, Patel, Amita, Nebbia, Gaia, Douthwaite, Sam, O'Connell, Lorcan, Luptak, Jakub, McCoy, Laura E, Brouwer, Philip, van Gils, Marit J, Sanders, Rogier W, Martinez Nunez, Rocio, Bisnauthsing, Karen, O'Hara, Geraldine, MacMahon, Eithne, Batra, Rahul, Malim, Michael H, Neil, Stuart J D, Doores, Katie J, Edgeworth, Jonathan D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies Antibodies, Viral - analysis Assaying Authorship Betacoronavirus Biology Biology and life sciences Chemiluminescence Clinical Laboratory Techniques Community health care Community Health Services Comparative analysis Coronavirus Infections - diagnosis Coronavirus Nucleocapsid Proteins Coronaviruses COVID-19 COVID-19 Testing Diagnosis Diagnostic software Diagnostic systems Enzyme-Linked Immunosorbent Assay Female Funding Health care Hospitals Humans Immunoassay Immunoassays Immunologic tests Immunology Infections Infectious diseases Luminescent Measurements Male Medical testing products Medicine and Health Sciences Middle Aged Nucleocapsid Proteins - immunology Nucleocapsids Pandemics Performance evaluation Phosphoproteins Platforms Pneumonia, Viral - diagnosis Point-of-Care Systems Public health Research and Analysis Methods RNA polymerase SARS-CoV-2 Sensitivity and Specificity Serologic Tests - methods Serology Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Signs and symptoms Spike Glycoprotein, Coronavirus - immunology Time dependence Viral diseases Viral infections
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