Mutation bias interacts with composition bias to influence adaptive evolution

Mutation is a biased stochastic process, with some types of mutations occurring more frequently than others. Previous work has used synthetic genotype-phenotype landscapes to study how such mutation bias affects adaptive evolution. Here, we consider 746 empirical genotype-phenotype landscapes, each...

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Veröffentlicht in:	PLoS computational biology 2020-09, Vol.16 (9), p.e1008296-e1008296
Hauptverfasser:	Cano, Alejandro V, Payne, Joshua L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Affinity Bias Binding Binding sites Bioinformatics Biology and life sciences Composition Computational Biology Deoxyribonucleic acid DNA DNA, Bacterial - chemistry DNA, Bacterial - genetics DNA, Bacterial - metabolism Evolution Evolution & development Evolution, Molecular Evolutionary adaptation Gene expression Gene sequencing Genetic aspects Genetic diversity Genotype Genotype & phenotype Genotypes Influence Models, Genetic Mutation Mutation - genetics Mutation - physiology Nucleotide sequence Phenotype Phenotypes Physical Sciences Physiological aspects Population Population genetics Protein Binding - genetics Proteins Software Stochastic processes Stochasticity Topography Transcription factors Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism
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