A complement component C1q-mediated mechanism of antibody-dependent enhancement of Ebola virus infection

Besides the common Fc receptor (FcR)-mediated mechanism of antibody-dependent enhancement (ADE), Ebola virus (EBOV) is known to utilize the complement component C1q for ADE of infection. This mechanism is FcR-independent and mediated by cross-linking of virus-antibody-C1q complexes to cell surface C...

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Veröffentlicht in:	PLoS neglected tropical diseases 2020-09, Vol.14 (9), p.e0008602
Hauptverfasser:	Furuyama, Wakako, Nanbo, Asuka, Maruyama, Junki, Marzi, Andrea, Takada, Ayato
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal - immunology Antibodies, Viral - immunology Antibody-Dependent Enhancement - immunology Biology and life sciences Cell Line Cell surface Cells Cellular signal transduction Chlorocebus aethiops Cloning Complement (Immunology) Complement C1q - metabolism Complement component C1q Confocal microscopy Crosslinking Ebola virus Ebolavirus Ebolavirus - immunology Ebolavirus - pathogenicity Endocytosis Endocytosis - immunology Endosomes Epidemiology Fc receptors Genetic aspects Glycoproteins Health aspects HEK293 Cells Hemorrhagic Fever, Ebola - immunology Hemorrhagic Fever, Ebola - pathology Humans Infections Infectious diseases Intracellular signalling Kinases Laboratories Matrix protein Medicine and Health Sciences Membrane Glycoproteins - metabolism Microscopy Monoclonal antibodies Phagocytosis Phenols Proteins Receptors Receptors, Complement - metabolism Sarcoma Signaling Software Tropical diseases Uptake Vero Cells Viral diseases Viral Proteins - immunology Viral Proteins - metabolism Virology Virulence (Microbiology) Virus Attachment Virus-like particles Viruses Zoonoses
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