Characterization of hepatic macrophages and evaluation of inflammatory response in heme oxygenase-1 deficient mice exposed to scAAV9 vectors

Adeno-associated viral (AAV) vectors are characterised by low immunogenicity, although humoral and cellular responses may be triggered upon infection. Following systemic administration high levels of vector particles accumulate within the liver. Kupffer cells (KCs) are liver resident macrophages and...

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Veröffentlicht in:	PloS one 2020-10, Vol.15 (10), p.e0240691-e0240691
Hauptverfasser:	Tomczyk, Mateusz, Kraszewska, Izabela, Mąka, Robert, Waligórska, Agnieszka, Dulak, Józef, Jaźwa-Kusior, Agnieszka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antigens Biochemistry Biology and Life Sciences Biophysics Biotechnology Cell culture Cells, Cultured Chemokine CCL2 - metabolism Deoxyribonucleic acid Dependovirus - metabolism Development and progression DNA Gene expression Gene Expression Regulation Gene therapy Genetic aspects Genetic vectors Genetic Vectors - metabolism Genomes Genotypes Green Fluorescent Proteins - metabolism Health aspects HEK293 Cells Heme Heme oxygenase (decyclizing) Heme Oxygenase-1 - deficiency Heme Oxygenase-1 - metabolism Hemoproteins Hepatocytes Humans Immune response Immune system Immunogenicity Inflammation Inflammation - blood Inflammation - genetics Inflammation - pathology Inflammatory response Innate immunity Interleukin-6 - blood Kupffer cells Kupffer Cells - pathology Liver Liver - pathology Liver research Macrophages Macrophages - pathology Medicine and Health Sciences Mice, Inbred C57BL Mice, Knockout Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes mRNA Oxygenase Pathogens Phenotype Proteins Signal Transduction - genetics State vectors TLR9 protein Toll-Like Receptor 9 - metabolism Toll-like receptors Transgenes Vectors (Biology)
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