Modulating electrospun polycaprolactone scaffold morphology and composition to alter endothelial cell proliferation and angiogenic gene response

The aim of this study was to look at how the composition and morphology of polymer scaffolds could be altered to create an optimized environment for endothelial cells. Four polycaprolactone (PCL) scaffolds were electrospun with increasing fibre diameters ranging from 1.64 μm to 4.83 μm. The scaffold...

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Veröffentlicht in:	PloS one 2020-10, Vol.15 (10), p.e0240332-e0240332
Hauptverfasser:	Reid, James Alexander, McDonald, Alison, Callanan, Anthony
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Aorta Bioengineering Biology and Life Sciences Cameras Cardiovascular disease Cell adhesion & migration Cell culture Cell Hypoxia Cell Proliferation Cell Survival Cell viability Composition Contact angle Culture Cytology Electron microscopy Electrospinning Endothelial cells Endothelium Engineering schools Extracellular matrix Extracellular Matrix - metabolism Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - metabolism Funding Gene expression Genetic aspects Growth factors Health aspects Human Umbilical Vein Endothelial Cells Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Medicine and Health Sciences Microscopy, Confocal Morphology Physical Sciences Physiological aspects Platelet Endothelial Cell Adhesion Molecule-1 - genetics Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Polycaprolactone Polyesters - chemistry Polymers Research and Analysis Methods Scaffolds Scanning electron microscopy Tensile Strength Tissue Scaffolds - chemistry Umbilical vein Veins & arteries
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