Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation

Human mesenchymal stem/stromal cells (hMSCs) are a promising therapy for acute respiratory distress syndrome (ARDS) and other inflammatory conditions. While considerable research has focused on paracrine effects and mitochondrial transfer that improve lung fluid balance, hMSCs are well known to have...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2020-10, Vol.15 (10), p.e0240319-e0240319
Hauptverfasser:	Wilfong, Erin M, Croze, Roxanne, Fang, Xiaohui, Schwede, Matthew, Niemi, Erene, López, Giselle Y, Lee, Jae-Woo, Nakamura, Mary C, Matthay, Michael A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult respiratory distress syndrome Biology and Life Sciences Bronchoalveolar Lavage Fluid - immunology Care and treatment CD40 antigen CD40 Antigens - genetics Cell Adhesion Molecules - genetics Cell Transdifferentiation Cells, Cultured Cloning Cyclooxygenase 2 - genetics Cytokines Cytokines - pharmacology Dioxygenase Edema Effectors Experiments Female Flow cytometry Health aspects Humans Immune response Immune system Immunomodulation Inflammation Laboratories Lipopolysaccharides - pharmacology Male Medicine Medicine and Health Sciences Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - immunology Mesenchyme Mitochondria Neutrophils Paracrine signalling Phenotypes Physiological aspects Properties (attributes) Pulmonary edema R&D Research & development Research and Analysis Methods Respiratory distress syndrome Respiratory Distress Syndrome - immunology Respiratory Distress Syndrome - therapy Sepsis Stromal cells Transcription Transcription, Genetic Tumor necrosis factor-TNF Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!