Patients with mild and general COVID-19 should be negative for at least 3 consecutive nucleic acid tests before discharged
Given the global spread of coronavirus disease (COVID-19), strict discharge standard is of great significance for the prevention and control of the epidemic, thus, the purpose of this study is to formulate more strict and scientific discharge standards. A total of 845 patients with mild and general...
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| description | Given the global spread of coronavirus disease (COVID-19), strict discharge standard is of great significance for the prevention and control of the epidemic, thus, the purpose of this study is to formulate more strict and scientific discharge standards. A total of 845 patients with mild and general COVID-19 who were considered to be discharged from hospital were included in this study. The median time from the onset of COVID-19 to the occurrence of two consecutive negative nucleic acid tests of these patients was 21 days. 223 of the 845 patients were tested again after two consecutive negative nucleic acid tests and 17.49% of the patients were positive. Moreover, 82.51% (184 of 223) of these patients experienced negative results from three consecutive nucleic acid tests, the median time from the onset of COVID-19 to the occurrence of three consecutive negative nucleic acid tests was 23 days (range: 3-56 days), and 38 of which were further tested after three consecutive negative nucleic acid tests, while about 5.26% (2 of 38) patients showed positive nucleic acid test results. Thus, we suggested that the patient should be negative for at least 3 consecutive nucleic acid tests before discharge, and the test time should be no earlier than the 23rd day since the onset of the disease. |
| doi_str_mv | 10.1371/journal.pone.0240081 |
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A total of 845 patients with mild and general COVID-19 who were considered to be discharged from hospital were included in this study. The median time from the onset of COVID-19 to the occurrence of two consecutive negative nucleic acid tests of these patients was 21 days. 223 of the 845 patients were tested again after two consecutive negative nucleic acid tests and 17.49% of the patients were positive. Moreover, 82.51% (184 of 223) of these patients experienced negative results from three consecutive nucleic acid tests, the median time from the onset of COVID-19 to the occurrence of three consecutive negative nucleic acid tests was 23 days (range: 3-56 days), and 38 of which were further tested after three consecutive negative nucleic acid tests, while about 5.26% (2 of 38) patients showed positive nucleic acid test results. Thus, we suggested that the patient should be negative for at least 3 consecutive nucleic acid tests before discharge, and the test time should be no earlier than the 23rd day since the onset of the disease.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0240081</identifier><identifier>PMID: 33007008</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acids ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Betacoronavirus - isolation & purification ; Biology and Life Sciences ; Body temperature ; Child ; China ; China - epidemiology ; Chinese medicine ; Clinical Laboratory Techniques ; Control ; Coronavirus Infections - diagnosis ; Coronavirus Infections - epidemiology ; Coronaviruses ; COVID-19 ; COVID-19 Testing ; Diagnosis ; Disease ; Disease control ; Disease transmission ; Epidemics ; Female ; Hospitals ; Humans ; Immunologic tests ; Male ; Medicine and Health Sciences ; Middle Aged ; Nucleic acids ; Orthopedics ; Pandemics ; Patient Discharge ; Patient outcomes ; Patients ; People and Places ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - epidemiology ; Probability ; Research and Analysis Methods ; Retrospective Studies ; RNA, Viral - analysis ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Viral diseases ; Young Adult</subject><ispartof>PloS one, 2020-10, Vol.15 (10), p.e0240081-e0240081</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Lu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Lu et al 2020 Lu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-35259536a12a223067ef772b7dba721690a3bde744a940caaff65364ccc294923</citedby><cites>FETCH-LOGICAL-c692t-35259536a12a223067ef772b7dba721690a3bde744a940caaff65364ccc294923</cites><orcidid>0000-0001-6179-0964</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531855/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531855/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2101,2927,23865,27923,27924,53790,53792,79471,79472</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33007008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hozbor, Daniela Flavia</contributor><creatorcontrib>Lu, Rui</creatorcontrib><creatorcontrib>Huang, Tianhui</creatorcontrib><creatorcontrib>Hu, Haiqing</creatorcontrib><creatorcontrib>Liu, Xiao-Ping</creatorcontrib><title>Patients with mild and general COVID-19 should be negative for at least 3 consecutive nucleic acid tests before discharged</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Given the global spread of coronavirus disease (COVID-19), strict discharge standard is of great significance for the prevention and control of the epidemic, thus, the purpose of this study is to formulate more strict and scientific discharge standards. A total of 845 patients with mild and general COVID-19 who were considered to be discharged from hospital were included in this study. The median time from the onset of COVID-19 to the occurrence of two consecutive negative nucleic acid tests of these patients was 21 days. 223 of the 845 patients were tested again after two consecutive negative nucleic acid tests and 17.49% of the patients were positive. Moreover, 82.51% (184 of 223) of these patients experienced negative results from three consecutive nucleic acid tests, the median time from the onset of COVID-19 to the occurrence of three consecutive negative nucleic acid tests was 23 days (range: 3-56 days), and 38 of which were further tested after three consecutive negative nucleic acid tests, while about 5.26% (2 of 38) patients showed positive nucleic acid test results. Thus, we suggested that the patient should be negative for at least 3 consecutive nucleic acid tests before discharge, and the test time should be no earlier than the 23rd day since the onset of the disease.</description><subject>Acids</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Betacoronavirus - isolation & purification</subject><subject>Biology and Life Sciences</subject><subject>Body temperature</subject><subject>Child</subject><subject>China</subject><subject>China - epidemiology</subject><subject>Chinese medicine</subject><subject>Clinical Laboratory Techniques</subject><subject>Control</subject><subject>Coronavirus Infections - diagnosis</subject><subject>Coronavirus Infections - epidemiology</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 Testing</subject><subject>Diagnosis</subject><subject>Disease</subject><subject>Disease control</subject><subject>Disease transmission</subject><subject>Epidemics</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunologic tests</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Nucleic acids</subject><subject>Orthopedics</subject><subject>Pandemics</subject><subject>Patient Discharge</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>People and Places</subject><subject>Pneumonia, Viral - diagnosis</subject><subject>Pneumonia, Viral - epidemiology</subject><subject>Probability</subject><subject>Research and Analysis Methods</subject><subject>Retrospective Studies</subject><subject>RNA, Viral - analysis</subject><subject>SARS-CoV-2</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Viral diseases</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1uP0zAQhSMEYpeFf4DAEhKChxbfEicvSKtyq7RSEZd9tRxnnLpK4xIny-XXM91mVw3aB5SHRJ7vHGeOPUnylNE5E4q92YSha00z34UW5pRLSnN2LzllheCzjFNx_-j7JHkU44bSVORZ9jA5EYJShYLT5M9n03to-0h--n5Ntr6piGkrUkMLnWnIYnW5fDdjBYnrMGCtBNJCjZorIC50xPSkARN7IogNbQQ7XJfawTbgLTHWV6SHiP4lIA-k8tGuTVdD9Th54EwT4cn4Pku-f3j_bfFpdrH6uFycX8xsVvB-JlKeFqnIDOOGc0EzBU4pXqqqNIqzrKBGlBUoKU0hqTXGuQxxaa3lhSy4OEueH3x3TYh6jC1qLmXOGM-oQmJ5IKpgNnrX-a3pfutgvL5eCF2tTdd7bEkrp1JBnU0pk1IyKF1BQUDumLScOYdeb8fdhnILlcVsMceJ6bTS-rWuw5VGX5anKRq8Gg268GPA6PQWI4OmMS2E4fDfkmYs3Xf24h_07u5GqjbYgG9dwH3t3lSfZwIjZCrPkZrfQeFTwdbj0YLzuD4RvJ4IkOnhV1-bIUa9_Prl_9nV5ZR9ecSuwTT9OoYG7xXerykoD6DtQowduNuQGdX7EblJQ-9HRI8jgrJnxwd0K7qZCfEXiIkKSw</recordid><startdate>20201002</startdate><enddate>20201002</enddate><creator>Lu, Rui</creator><creator>Huang, Tianhui</creator><creator>Hu, Haiqing</creator><creator>Liu, Xiao-Ping</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>COVID</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6179-0964</orcidid></search><sort><creationdate>20201002</creationdate><title>Patients with mild and general COVID-19 should be negative for at least 3 consecutive nucleic acid tests before discharged</title><author>Lu, Rui ; Huang, Tianhui ; Hu, Haiqing ; Liu, Xiao-Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-35259536a12a223067ef772b7dba721690a3bde744a940caaff65364ccc294923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acids</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Betacoronavirus - isolation & purification</topic><topic>Biology and Life Sciences</topic><topic>Body temperature</topic><topic>Child</topic><topic>China</topic><topic>China - epidemiology</topic><topic>Chinese medicine</topic><topic>Clinical Laboratory Techniques</topic><topic>Control</topic><topic>Coronavirus Infections - diagnosis</topic><topic>Coronavirus Infections - epidemiology</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 Testing</topic><topic>Diagnosis</topic><topic>Disease</topic><topic>Disease control</topic><topic>Disease transmission</topic><topic>Epidemics</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunologic tests</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Nucleic acids</topic><topic>Orthopedics</topic><topic>Pandemics</topic><topic>Patient Discharge</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>People and Places</topic><topic>Pneumonia, Viral - diagnosis</topic><topic>Pneumonia, Viral - epidemiology</topic><topic>Probability</topic><topic>Research and Analysis Methods</topic><topic>Retrospective Studies</topic><topic>RNA, Viral - analysis</topic><topic>SARS-CoV-2</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Viral diseases</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Rui</creatorcontrib><creatorcontrib>Huang, Tianhui</creatorcontrib><creatorcontrib>Hu, Haiqing</creatorcontrib><creatorcontrib>Liu, Xiao-Ping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Rui</au><au>Huang, Tianhui</au><au>Hu, Haiqing</au><au>Liu, Xiao-Ping</au><au>Hozbor, Daniela Flavia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patients with mild and general COVID-19 should be negative for at least 3 consecutive nucleic acid tests before discharged</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-10-02</date><risdate>2020</risdate><volume>15</volume><issue>10</issue><spage>e0240081</spage><epage>e0240081</epage><pages>e0240081-e0240081</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Given the global spread of coronavirus disease (COVID-19), strict discharge standard is of great significance for the prevention and control of the epidemic, thus, the purpose of this study is to formulate more strict and scientific discharge standards. A total of 845 patients with mild and general COVID-19 who were considered to be discharged from hospital were included in this study. The median time from the onset of COVID-19 to the occurrence of two consecutive negative nucleic acid tests of these patients was 21 days. 223 of the 845 patients were tested again after two consecutive negative nucleic acid tests and 17.49% of the patients were positive. Moreover, 82.51% (184 of 223) of these patients experienced negative results from three consecutive nucleic acid tests, the median time from the onset of COVID-19 to the occurrence of three consecutive negative nucleic acid tests was 23 days (range: 3-56 days), and 38 of which were further tested after three consecutive negative nucleic acid tests, while about 5.26% (2 of 38) patients showed positive nucleic acid test results. Thus, we suggested that the patient should be negative for at least 3 consecutive nucleic acid tests before discharge, and the test time should be no earlier than the 23rd day since the onset of the disease.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33007008</pmid><doi>10.1371/journal.pone.0240081</doi><orcidid>https://orcid.org/0000-0001-6179-0964</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acids Adolescent Adult Aged Aged, 80 and over Betacoronavirus - isolation & purification Biology and Life Sciences Body temperature Child China China - epidemiology Chinese medicine Clinical Laboratory Techniques Control Coronavirus Infections - diagnosis Coronavirus Infections - epidemiology Coronaviruses COVID-19 COVID-19 Testing Diagnosis Disease Disease control Disease transmission Epidemics Female Hospitals Humans Immunologic tests Male Medicine and Health Sciences Middle Aged Nucleic acids Orthopedics Pandemics Patient Discharge Patient outcomes Patients People and Places Pneumonia, Viral - diagnosis Pneumonia, Viral - epidemiology Probability Research and Analysis Methods Retrospective Studies RNA, Viral - analysis SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Viral diseases Young Adult |
| title | Patients with mild and general COVID-19 should be negative for at least 3 consecutive nucleic acid tests before discharged |
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