18-24-month HIV-free survival as measurement of the effectiveness of prevention of mother-to-child transmission in the context of lifelong antiretroviral therapy: Results of a community-based survey
Between November 2015 and December 2016, we conducted a survey among households with a child born 18-24 months prior to data collection. Catchment areas from 25 health facilities in Butha-Buthe, Maseru, Mohale's Hoek and Thaba-Tseka districts were randomly selected using probability proportiona...
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| creator | Tiam, Appolinaire Gill, Michelle M Machekano, Rhoderick Tukei, Vincent Mokone, Majoalane Viana, Shannon Letsie, Mosilinyane Tsietso, Mots'oane Seipati, Irene Khachane, Cecilia Nei, Marethabile Mohai, Florence Tylleskär, Thorkild Guay, Laura |
| description | Between November 2015 and December 2016, we conducted a survey among households with a child born 18-24 months prior to data collection. Catchment areas from 25 health facilities in Butha-Buthe, Maseru, Mohale's Hoek and Thaba-Tseka districts were randomly selected using probability proportional to size sampling. Consecutive households were visited and eligible consenting caregivers and children were enrolled. Of the 1,852 mothers/caregivers enrolled, 570 mothers were HIV-positive. The mother-to-child HIV transmission rate was 5.7% [95% CI: 4.0-8.0]. The mortality rate was 2.6% [95% CI: 1.6-4.2] among HIV-exposed children compared to 1.4% (95% CI: 0.9-2.3) among HIV-unexposed children. HIV-free survival was 91.8% [95% CI: 89.2-93.8] among HIV-exposed infants. Disclosure of mother's HIV status (aOR = 4.9, 95% CI: 1.3-18.2) and initiation of cotrimoxazole prophylaxis in the child (aOR = 3.9, 95% CI: 1.2-12.6) were independently associated with increased HIV-free survival while child growth problems (aOR = 0.2, 95% CI: 0.09-0.5) were independently associated with reduced HIV-free survival. Even in the context of lifelong antiretroviral therapy among pregnant and breastfeeding women, HIV has a significant effect on survival among HIV-exposed children compared to unexposed children. Lesotho has not reached elimination of HIV transmission from mother to child. |
| doi_str_mv | 10.1371/journal.pone.0237409 |
| format | Article |
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Catchment areas from 25 health facilities in Butha-Buthe, Maseru, Mohale's Hoek and Thaba-Tseka districts were randomly selected using probability proportional to size sampling. Consecutive households were visited and eligible consenting caregivers and children were enrolled. Of the 1,852 mothers/caregivers enrolled, 570 mothers were HIV-positive. The mother-to-child HIV transmission rate was 5.7% [95% CI: 4.0-8.0]. The mortality rate was 2.6% [95% CI: 1.6-4.2] among HIV-exposed children compared to 1.4% (95% CI: 0.9-2.3) among HIV-unexposed children. HIV-free survival was 91.8% [95% CI: 89.2-93.8] among HIV-exposed infants. Disclosure of mother's HIV status (aOR = 4.9, 95% CI: 1.3-18.2) and initiation of cotrimoxazole prophylaxis in the child (aOR = 3.9, 95% CI: 1.2-12.6) were independently associated with increased HIV-free survival while child growth problems (aOR = 0.2, 95% CI: 0.09-0.5) were independently associated with reduced HIV-free survival. Even in the context of lifelong antiretroviral therapy among pregnant and breastfeeding women, HIV has a significant effect on survival among HIV-exposed children compared to unexposed children. Lesotho has not reached elimination of HIV transmission from mother to child.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0237409</identifier><identifier>PMID: 33002002</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Acquired immune deficiency syndrome ; Age ; AIDS ; Antibodies ; Antiretroviral agents ; Antiretroviral drugs ; Antiretroviral therapy ; Biology and Life Sciences ; Breast feeding ; Breastfeeding & lactation ; Caregivers ; Catchment areas ; Children ; Children & youth ; Context ; Cotrimoxazole ; Data collection ; Demographics ; Demography ; Deoxyribonucleic acid ; Disease transmission ; DNA ; Drug therapy ; Exposure ; Health care facilities ; Health facilities ; Highly active antiretroviral therapy ; HIV ; HIV infections ; Households ; Human immunodeficiency virus ; Infants ; Medical tests ; Medicine and Health Sciences ; Mortality ; Patient outcomes ; Pediatrics ; People and Places ; Perinatal infection ; Polls & surveys ; Population ; Pregnancy ; Prevention ; Prophylaxis ; Public health ; Rank tests ; Sample size ; Subgroups ; Survival</subject><ispartof>PloS one, 2020-10, Vol.15 (10), p.e0237409-e0237409</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Tiam et al. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Tiam et al 2020 Tiam et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-4c0fb262d37bb1e30643fcd6703a759077a069d9092e27fa7324edf48af4e5b13</citedby><cites>FETCH-LOGICAL-c669t-4c0fb262d37bb1e30643fcd6703a759077a069d9092e27fa7324edf48af4e5b13</cites><orcidid>0000-0002-8045-7590</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529246/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529246/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids></links><search><contributor>Torpey, Kwasi</contributor><creatorcontrib>Tiam, Appolinaire</creatorcontrib><creatorcontrib>Gill, Michelle M</creatorcontrib><creatorcontrib>Machekano, Rhoderick</creatorcontrib><creatorcontrib>Tukei, Vincent</creatorcontrib><creatorcontrib>Mokone, Majoalane</creatorcontrib><creatorcontrib>Viana, Shannon</creatorcontrib><creatorcontrib>Letsie, Mosilinyane</creatorcontrib><creatorcontrib>Tsietso, Mots'oane</creatorcontrib><creatorcontrib>Seipati, Irene</creatorcontrib><creatorcontrib>Khachane, Cecilia</creatorcontrib><creatorcontrib>Nei, Marethabile</creatorcontrib><creatorcontrib>Mohai, Florence</creatorcontrib><creatorcontrib>Tylleskär, Thorkild</creatorcontrib><creatorcontrib>Guay, Laura</creatorcontrib><title>18-24-month HIV-free survival as measurement of the effectiveness of prevention of mother-to-child transmission in the context of lifelong antiretroviral therapy: Results of a community-based survey</title><title>PloS one</title><description>Between November 2015 and December 2016, we conducted a survey among households with a child born 18-24 months prior to data collection. Catchment areas from 25 health facilities in Butha-Buthe, Maseru, Mohale's Hoek and Thaba-Tseka districts were randomly selected using probability proportional to size sampling. Consecutive households were visited and eligible consenting caregivers and children were enrolled. Of the 1,852 mothers/caregivers enrolled, 570 mothers were HIV-positive. The mother-to-child HIV transmission rate was 5.7% [95% CI: 4.0-8.0]. The mortality rate was 2.6% [95% CI: 1.6-4.2] among HIV-exposed children compared to 1.4% (95% CI: 0.9-2.3) among HIV-unexposed children. HIV-free survival was 91.8% [95% CI: 89.2-93.8] among HIV-exposed infants. Disclosure of mother's HIV status (aOR = 4.9, 95% CI: 1.3-18.2) and initiation of cotrimoxazole prophylaxis in the child (aOR = 3.9, 95% CI: 1.2-12.6) were independently associated with increased HIV-free survival while child growth problems (aOR = 0.2, 95% CI: 0.09-0.5) were independently associated with reduced HIV-free survival. Even in the context of lifelong antiretroviral therapy among pregnant and breastfeeding women, HIV has a significant effect on survival among HIV-exposed children compared to unexposed children. Lesotho has not reached elimination of HIV transmission from mother to child.</description><subject>Acquired immune deficiency syndrome</subject><subject>Age</subject><subject>AIDS</subject><subject>Antibodies</subject><subject>Antiretroviral agents</subject><subject>Antiretroviral drugs</subject><subject>Antiretroviral therapy</subject><subject>Biology and Life Sciences</subject><subject>Breast feeding</subject><subject>Breastfeeding & lactation</subject><subject>Caregivers</subject><subject>Catchment areas</subject><subject>Children</subject><subject>Children & youth</subject><subject>Context</subject><subject>Cotrimoxazole</subject><subject>Data collection</subject><subject>Demographics</subject><subject>Demography</subject><subject>Deoxyribonucleic acid</subject><subject>Disease transmission</subject><subject>DNA</subject><subject>Drug therapy</subject><subject>Exposure</subject><subject>Health care facilities</subject><subject>Health facilities</subject><subject>Highly active antiretroviral therapy</subject><subject>HIV</subject><subject>HIV infections</subject><subject>Households</subject><subject>Human immunodeficiency virus</subject><subject>Infants</subject><subject>Medical tests</subject><subject>Medicine and Health Sciences</subject><subject>Mortality</subject><subject>Patient outcomes</subject><subject>Pediatrics</subject><subject>People and Places</subject><subject>Perinatal infection</subject><subject>Polls & surveys</subject><subject>Population</subject><subject>Pregnancy</subject><subject>Prevention</subject><subject>Prophylaxis</subject><subject>Public health</subject><subject>Rank tests</subject><subject>Sample 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HIV-free survival as measurement of the effectiveness of prevention of mother-to-child transmission in the context of lifelong antiretroviral therapy: Results of a community-based survey</title><author>Tiam, Appolinaire ; Gill, Michelle M ; Machekano, Rhoderick ; Tukei, Vincent ; Mokone, Majoalane ; Viana, Shannon ; Letsie, Mosilinyane ; Tsietso, Mots'oane ; Seipati, Irene ; Khachane, Cecilia ; Nei, Marethabile ; Mohai, Florence ; Tylleskär, Thorkild ; Guay, Laura</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-4c0fb262d37bb1e30643fcd6703a759077a069d9092e27fa7324edf48af4e5b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Age</topic><topic>AIDS</topic><topic>Antibodies</topic><topic>Antiretroviral agents</topic><topic>Antiretroviral drugs</topic><topic>Antiretroviral therapy</topic><topic>Biology and Life 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Kwasi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>18-24-month HIV-free survival as measurement of the effectiveness of prevention of mother-to-child transmission in the context of lifelong antiretroviral therapy: Results of a community-based survey</atitle><jtitle>PloS one</jtitle><date>2020-10-01</date><risdate>2020</risdate><volume>15</volume><issue>10</issue><spage>e0237409</spage><epage>e0237409</epage><pages>e0237409-e0237409</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Between November 2015 and December 2016, we conducted a survey among households with a child born 18-24 months prior to data collection. Catchment areas from 25 health facilities in Butha-Buthe, Maseru, Mohale's Hoek and Thaba-Tseka districts were randomly selected using probability proportional to size sampling. Consecutive households were visited and eligible consenting caregivers and children were enrolled. Of the 1,852 mothers/caregivers enrolled, 570 mothers were HIV-positive. The mother-to-child HIV transmission rate was 5.7% [95% CI: 4.0-8.0]. The mortality rate was 2.6% [95% CI: 1.6-4.2] among HIV-exposed children compared to 1.4% (95% CI: 0.9-2.3) among HIV-unexposed children. HIV-free survival was 91.8% [95% CI: 89.2-93.8] among HIV-exposed infants. Disclosure of mother's HIV status (aOR = 4.9, 95% CI: 1.3-18.2) and initiation of cotrimoxazole prophylaxis in the child (aOR = 3.9, 95% CI: 1.2-12.6) were independently associated with increased HIV-free survival while child growth problems (aOR = 0.2, 95% CI: 0.09-0.5) were independently associated with reduced HIV-free survival. Even in the context of lifelong antiretroviral therapy among pregnant and breastfeeding women, HIV has a significant effect on survival among HIV-exposed children compared to unexposed children. Lesotho has not reached elimination of HIV transmission from mother to child.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>33002002</pmid><doi>10.1371/journal.pone.0237409</doi><tpages>e0237409</tpages><orcidid>https://orcid.org/0000-0002-8045-7590</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-10, Vol.15 (10), p.e0237409-e0237409 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2447830978 |
| source | NCBI_PubMed Central（免费）; Public Library of Science; DOAJ Directory of Open Access Journals; Free Full-Text Journals in Chemistry; EZB* |
| subjects | Acquired immune deficiency syndrome Age AIDS Antibodies Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Biology and Life Sciences Breast feeding Breastfeeding & lactation Caregivers Catchment areas Children Children & youth Context Cotrimoxazole Data collection Demographics Demography Deoxyribonucleic acid Disease transmission DNA Drug therapy Exposure Health care facilities Health facilities Highly active antiretroviral therapy HIV HIV infections Households Human immunodeficiency virus Infants Medical tests Medicine and Health Sciences Mortality Patient outcomes Pediatrics People and Places Perinatal infection Polls & surveys Population Pregnancy Prevention Prophylaxis Public health Rank tests Sample size Subgroups Survival |
| title | 18-24-month HIV-free survival as measurement of the effectiveness of prevention of mother-to-child transmission in the context of lifelong antiretroviral therapy: Results of a community-based survey |
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