Assessment of the functional efficacy of root canal treatment with high-frequency waves in rats
The purpose of this study was to develop a high-frequency wave therapy model in rats and to investigate the influence of high-frequency waves on root canal treatment, which may provide a novel strategy for treating apical periodontitis. Root canal treatments with and without high-frequency wave irra...
Gespeichert in:
| Veröffentlicht in: | PloS one 2020-09, Vol.15 (9), p.e0239660-e0239660 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0239660 |
|---|---|
| container_issue | 9 |
| container_start_page | e0239660 |
| container_title | PloS one |
| container_volume | 15 |
| creator | Matsui, Saori Yoneda, Naomichi Maezono, Hazuki Kuremoto, Katsutaka Ishimoto, Takuya Nakano, Takayoshi Yumoto, Hiromichi Ebisu, Shigeyuki Noiri, Yuichiro Hayashi, Mikako |
| description | The purpose of this study was to develop a high-frequency wave therapy model in rats and to investigate the influence of high-frequency waves on root canal treatment, which may provide a novel strategy for treating apical periodontitis. Root canal treatments with and without high-frequency wave irradiation were performed on the mandibular first molars of 10-week-old male Wistar rats. The mesial roots were evaluated radiologically, bacteriologically, and immunohistochemically. At 3 weeks after root canal treatment, lesion volume had decreased significantly more in the irradiated group than in the non-irradiated group, indicating successful development of the high-frequency therapy model. The use of high-frequency waves provided no additional bactericidal effect after root canal treatment. However, high-frequency wave irradiation was found to promote healing of periapical lesions on the host side through increased expression of fibroblast growth factor 2 and transforming growth factor-β1 and could therefore be useful as an adjuvant nonsurgical treatment for apical periodontitis. |
| doi_str_mv | 10.1371/journal.pone.0239660 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2447246278</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A636883564</galeid><doaj_id>oai_doaj_org_article_40fc48eae168447d9c9638373d24aa31</doaj_id><sourcerecordid>A636883564</sourcerecordid><originalsourceid>FETCH-LOGICAL-c802t-61587877241a3eb550c5bde37d5c10edeb09961b7c80034f5aa22166741acc253</originalsourceid><addsrcrecordid>eNqNk9tq3DAQhk1paNJt36C0hkJpLnargy3bN4Ul9LAQCPR0K2bl0VqL19pKctK8feWsE9YlF0UXFqPv_8cazSTJK0oWlBf0w9b2roN2sbcdLgjjlRDkSXJGK87mghH-9Gh_mjz3fktIzkshniWnnFUVFYSeJXLpPXq_wy6kVqehwVT3nQrGRu8UtTYK1O1w5KwNqYIhHBxCuJPcmNCkjdk0c-3wd49dZG_gGn1qutRB8C-SEw2tx5fjd5b8_Pzpx8XX-eXVl9XF8nKuSsLCXNC8LMqiYBkFjus8Jypf18iLOleUYI1rUlWCrouIE57pHIAxKkQReaVYzmfJm4PvvrVejrXxkmVZ9BSsKCOxOhC1ha3cO7MDdystGHkXsG4jwQWjWpQZ0SorEZCKMhrUlaoEL3nBa5YBcBq9Po7Z-vUOaxVL4aCdmE5POtPIjb2WRR4fqhwM3o8Gzsay-SB3xitsW-jQ9of_zrNyyDlL3v6DPn67kdpAvIDptI151WAql4KL6JSLLFKLR6i4atwZFRtJmxifCM4ngsgE_BM20HsvV9-__T979WvKvjtiG4Q2NN62_dB3fgpmB1A5671D_VBkSuQwB_fVkMMcyHEOouz18QM9iO4bn_8Fl_0CGA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2447246278</pqid></control><display><type>article</type><title>Assessment of the functional efficacy of root canal treatment with high-frequency waves in rats</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Matsui, Saori ; Yoneda, Naomichi ; Maezono, Hazuki ; Kuremoto, Katsutaka ; Ishimoto, Takuya ; Nakano, Takayoshi ; Yumoto, Hiromichi ; Ebisu, Shigeyuki ; Noiri, Yuichiro ; Hayashi, Mikako</creator><contributor>Bencharit, Sompop</contributor><creatorcontrib>Matsui, Saori ; Yoneda, Naomichi ; Maezono, Hazuki ; Kuremoto, Katsutaka ; Ishimoto, Takuya ; Nakano, Takayoshi ; Yumoto, Hiromichi ; Ebisu, Shigeyuki ; Noiri, Yuichiro ; Hayashi, Mikako ; Bencharit, Sompop</creatorcontrib><description>The purpose of this study was to develop a high-frequency wave therapy model in rats and to investigate the influence of high-frequency waves on root canal treatment, which may provide a novel strategy for treating apical periodontitis. Root canal treatments with and without high-frequency wave irradiation were performed on the mandibular first molars of 10-week-old male Wistar rats. The mesial roots were evaluated radiologically, bacteriologically, and immunohistochemically. At 3 weeks after root canal treatment, lesion volume had decreased significantly more in the irradiated group than in the non-irradiated group, indicating successful development of the high-frequency therapy model. The use of high-frequency waves provided no additional bactericidal effect after root canal treatment. However, high-frequency wave irradiation was found to promote healing of periapical lesions on the host side through increased expression of fibroblast growth factor 2 and transforming growth factor-β1 and could therefore be useful as an adjuvant nonsurgical treatment for apical periodontitis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0239660</identifier><identifier>PMID: 32991601</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animal models ; Animals ; Bacteria ; Bacteria - genetics ; Bacteria - isolation & purification ; Bacterial infections ; Biology and Life Sciences ; Bone surgery ; Care and treatment ; Composite materials ; Dental Pulp Cavity - diagnostic imaging ; Dental Pulp Cavity - pathology ; Dental roots ; Dentistry ; Diathermy ; DNA, Bacterial - isolation & purification ; DNA, Bacterial - metabolism ; Electrodes ; Endodontics ; Engineering and Technology ; Engineering schools ; Fibroblast growth factor 2 ; Fibroblast Growth Factor 2 - metabolism ; Gene expression ; Graduate studies ; Growth factors ; Gum disease ; Imaging, Three-Dimensional ; Immune system ; Infections ; Interleukin-1beta - metabolism ; Irradiation ; Lesions ; Male ; Manufacturing ; Medicine and Health Sciences ; Methods ; Molar - pathology ; Molars ; Periapical Periodontitis - microbiology ; Periapical Periodontitis - pathology ; Periapical Periodontitis - therapy ; Periodontitis ; Radiation ; Radio Waves ; Rats ; Rats, Wistar ; Root canal therapy ; Root Canal Therapy - methods ; Root canals ; Teeth ; Transforming Growth Factor beta1 - metabolism ; University graduates ; Waves ; X-Ray Microtomography</subject><ispartof>PloS one, 2020-09, Vol.15 (9), p.e0239660-e0239660</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Matsui et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Matsui et al 2020 Matsui et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c802t-61587877241a3eb550c5bde37d5c10edeb09961b7c80034f5aa22166741acc253</citedby><cites>FETCH-LOGICAL-c802t-61587877241a3eb550c5bde37d5c10edeb09961b7c80034f5aa22166741acc253</cites><orcidid>0000-0002-8659-9776 ; 0000-0002-1929-2045 ; 0000-0001-8052-1698</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523981/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523981/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32991601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bencharit, Sompop</contributor><creatorcontrib>Matsui, Saori</creatorcontrib><creatorcontrib>Yoneda, Naomichi</creatorcontrib><creatorcontrib>Maezono, Hazuki</creatorcontrib><creatorcontrib>Kuremoto, Katsutaka</creatorcontrib><creatorcontrib>Ishimoto, Takuya</creatorcontrib><creatorcontrib>Nakano, Takayoshi</creatorcontrib><creatorcontrib>Yumoto, Hiromichi</creatorcontrib><creatorcontrib>Ebisu, Shigeyuki</creatorcontrib><creatorcontrib>Noiri, Yuichiro</creatorcontrib><creatorcontrib>Hayashi, Mikako</creatorcontrib><title>Assessment of the functional efficacy of root canal treatment with high-frequency waves in rats</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The purpose of this study was to develop a high-frequency wave therapy model in rats and to investigate the influence of high-frequency waves on root canal treatment, which may provide a novel strategy for treating apical periodontitis. Root canal treatments with and without high-frequency wave irradiation were performed on the mandibular first molars of 10-week-old male Wistar rats. The mesial roots were evaluated radiologically, bacteriologically, and immunohistochemically. At 3 weeks after root canal treatment, lesion volume had decreased significantly more in the irradiated group than in the non-irradiated group, indicating successful development of the high-frequency therapy model. The use of high-frequency waves provided no additional bactericidal effect after root canal treatment. However, high-frequency wave irradiation was found to promote healing of periapical lesions on the host side through increased expression of fibroblast growth factor 2 and transforming growth factor-β1 and could therefore be useful as an adjuvant nonsurgical treatment for apical periodontitis.</description><subject>Animal models</subject><subject>Animals</subject><subject>Bacteria</subject><subject>Bacteria - genetics</subject><subject>Bacteria - isolation & purification</subject><subject>Bacterial infections</subject><subject>Biology and Life Sciences</subject><subject>Bone surgery</subject><subject>Care and treatment</subject><subject>Composite materials</subject><subject>Dental Pulp Cavity - diagnostic imaging</subject><subject>Dental Pulp Cavity - pathology</subject><subject>Dental roots</subject><subject>Dentistry</subject><subject>Diathermy</subject><subject>DNA, Bacterial - isolation & purification</subject><subject>DNA, Bacterial - metabolism</subject><subject>Electrodes</subject><subject>Endodontics</subject><subject>Engineering and Technology</subject><subject>Engineering schools</subject><subject>Fibroblast growth factor 2</subject><subject>Fibroblast Growth Factor 2 - metabolism</subject><subject>Gene expression</subject><subject>Graduate studies</subject><subject>Growth factors</subject><subject>Gum disease</subject><subject>Imaging, Three-Dimensional</subject><subject>Immune system</subject><subject>Infections</subject><subject>Interleukin-1beta - metabolism</subject><subject>Irradiation</subject><subject>Lesions</subject><subject>Male</subject><subject>Manufacturing</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Molar - pathology</subject><subject>Molars</subject><subject>Periapical Periodontitis - microbiology</subject><subject>Periapical Periodontitis - pathology</subject><subject>Periapical Periodontitis - therapy</subject><subject>Periodontitis</subject><subject>Radiation</subject><subject>Radio Waves</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Root canal therapy</subject><subject>Root Canal Therapy - methods</subject><subject>Root canals</subject><subject>Teeth</subject><subject>Transforming Growth Factor beta1 - metabolism</subject><subject>University graduates</subject><subject>Waves</subject><subject>X-Ray Microtomography</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tq3DAQhk1paNJt36C0hkJpLnargy3bN4Ul9LAQCPR0K2bl0VqL19pKctK8feWsE9YlF0UXFqPv_8cazSTJK0oWlBf0w9b2roN2sbcdLgjjlRDkSXJGK87mghH-9Gh_mjz3fktIzkshniWnnFUVFYSeJXLpPXq_wy6kVqehwVT3nQrGRu8UtTYK1O1w5KwNqYIhHBxCuJPcmNCkjdk0c-3wd49dZG_gGn1qutRB8C-SEw2tx5fjd5b8_Pzpx8XX-eXVl9XF8nKuSsLCXNC8LMqiYBkFjus8Jypf18iLOleUYI1rUlWCrouIE57pHIAxKkQReaVYzmfJm4PvvrVejrXxkmVZ9BSsKCOxOhC1ha3cO7MDdystGHkXsG4jwQWjWpQZ0SorEZCKMhrUlaoEL3nBa5YBcBq9Po7Z-vUOaxVL4aCdmE5POtPIjb2WRR4fqhwM3o8Gzsay-SB3xitsW-jQ9of_zrNyyDlL3v6DPn67kdpAvIDptI151WAql4KL6JSLLFKLR6i4atwZFRtJmxifCM4ngsgE_BM20HsvV9-__T979WvKvjtiG4Q2NN62_dB3fgpmB1A5671D_VBkSuQwB_fVkMMcyHEOouz18QM9iO4bn_8Fl_0CGA</recordid><startdate>20200929</startdate><enddate>20200929</enddate><creator>Matsui, Saori</creator><creator>Yoneda, Naomichi</creator><creator>Maezono, Hazuki</creator><creator>Kuremoto, Katsutaka</creator><creator>Ishimoto, Takuya</creator><creator>Nakano, Takayoshi</creator><creator>Yumoto, Hiromichi</creator><creator>Ebisu, Shigeyuki</creator><creator>Noiri, Yuichiro</creator><creator>Hayashi, Mikako</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8659-9776</orcidid><orcidid>https://orcid.org/0000-0002-1929-2045</orcidid><orcidid>https://orcid.org/0000-0001-8052-1698</orcidid></search><sort><creationdate>20200929</creationdate><title>Assessment of the functional efficacy of root canal treatment with high-frequency waves in rats</title><author>Matsui, Saori ; Yoneda, Naomichi ; Maezono, Hazuki ; Kuremoto, Katsutaka ; Ishimoto, Takuya ; Nakano, Takayoshi ; Yumoto, Hiromichi ; Ebisu, Shigeyuki ; Noiri, Yuichiro ; Hayashi, Mikako</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c802t-61587877241a3eb550c5bde37d5c10edeb09961b7c80034f5aa22166741acc253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Bacteria</topic><topic>Bacteria - genetics</topic><topic>Bacteria - isolation & purification</topic><topic>Bacterial infections</topic><topic>Biology and Life Sciences</topic><topic>Bone surgery</topic><topic>Care and treatment</topic><topic>Composite materials</topic><topic>Dental Pulp Cavity - diagnostic imaging</topic><topic>Dental Pulp Cavity - pathology</topic><topic>Dental roots</topic><topic>Dentistry</topic><topic>Diathermy</topic><topic>DNA, Bacterial - isolation & purification</topic><topic>DNA, Bacterial - metabolism</topic><topic>Electrodes</topic><topic>Endodontics</topic><topic>Engineering and Technology</topic><topic>Engineering schools</topic><topic>Fibroblast growth factor 2</topic><topic>Fibroblast Growth Factor 2 - metabolism</topic><topic>Gene expression</topic><topic>Graduate studies</topic><topic>Growth factors</topic><topic>Gum disease</topic><topic>Imaging, Three-Dimensional</topic><topic>Immune system</topic><topic>Infections</topic><topic>Interleukin-1beta - metabolism</topic><topic>Irradiation</topic><topic>Lesions</topic><topic>Male</topic><topic>Manufacturing</topic><topic>Medicine and Health Sciences</topic><topic>Methods</topic><topic>Molar - pathology</topic><topic>Molars</topic><topic>Periapical Periodontitis - microbiology</topic><topic>Periapical Periodontitis - pathology</topic><topic>Periapical Periodontitis - therapy</topic><topic>Periodontitis</topic><topic>Radiation</topic><topic>Radio Waves</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Root canal therapy</topic><topic>Root Canal Therapy - methods</topic><topic>Root canals</topic><topic>Teeth</topic><topic>Transforming Growth Factor beta1 - metabolism</topic><topic>University graduates</topic><topic>Waves</topic><topic>X-Ray Microtomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsui, Saori</creatorcontrib><creatorcontrib>Yoneda, Naomichi</creatorcontrib><creatorcontrib>Maezono, Hazuki</creatorcontrib><creatorcontrib>Kuremoto, Katsutaka</creatorcontrib><creatorcontrib>Ishimoto, Takuya</creatorcontrib><creatorcontrib>Nakano, Takayoshi</creatorcontrib><creatorcontrib>Yumoto, Hiromichi</creatorcontrib><creatorcontrib>Ebisu, Shigeyuki</creatorcontrib><creatorcontrib>Noiri, Yuichiro</creatorcontrib><creatorcontrib>Hayashi, Mikako</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsui, Saori</au><au>Yoneda, Naomichi</au><au>Maezono, Hazuki</au><au>Kuremoto, Katsutaka</au><au>Ishimoto, Takuya</au><au>Nakano, Takayoshi</au><au>Yumoto, Hiromichi</au><au>Ebisu, Shigeyuki</au><au>Noiri, Yuichiro</au><au>Hayashi, Mikako</au><au>Bencharit, Sompop</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of the functional efficacy of root canal treatment with high-frequency waves in rats</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-09-29</date><risdate>2020</risdate><volume>15</volume><issue>9</issue><spage>e0239660</spage><epage>e0239660</epage><pages>e0239660-e0239660</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The purpose of this study was to develop a high-frequency wave therapy model in rats and to investigate the influence of high-frequency waves on root canal treatment, which may provide a novel strategy for treating apical periodontitis. Root canal treatments with and without high-frequency wave irradiation were performed on the mandibular first molars of 10-week-old male Wistar rats. The mesial roots were evaluated radiologically, bacteriologically, and immunohistochemically. At 3 weeks after root canal treatment, lesion volume had decreased significantly more in the irradiated group than in the non-irradiated group, indicating successful development of the high-frequency therapy model. The use of high-frequency waves provided no additional bactericidal effect after root canal treatment. However, high-frequency wave irradiation was found to promote healing of periapical lesions on the host side through increased expression of fibroblast growth factor 2 and transforming growth factor-β1 and could therefore be useful as an adjuvant nonsurgical treatment for apical periodontitis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32991601</pmid><doi>10.1371/journal.pone.0239660</doi><tpages>e0239660</tpages><orcidid>https://orcid.org/0000-0002-8659-9776</orcidid><orcidid>https://orcid.org/0000-0002-1929-2045</orcidid><orcidid>https://orcid.org/0000-0001-8052-1698</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-09, Vol.15 (9), p.e0239660-e0239660 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2447246278 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animal models Animals Bacteria Bacteria - genetics Bacteria - isolation & purification Bacterial infections Biology and Life Sciences Bone surgery Care and treatment Composite materials Dental Pulp Cavity - diagnostic imaging Dental Pulp Cavity - pathology Dental roots Dentistry Diathermy DNA, Bacterial - isolation & purification DNA, Bacterial - metabolism Electrodes Endodontics Engineering and Technology Engineering schools Fibroblast growth factor 2 Fibroblast Growth Factor 2 - metabolism Gene expression Graduate studies Growth factors Gum disease Imaging, Three-Dimensional Immune system Infections Interleukin-1beta - metabolism Irradiation Lesions Male Manufacturing Medicine and Health Sciences Methods Molar - pathology Molars Periapical Periodontitis - microbiology Periapical Periodontitis - pathology Periapical Periodontitis - therapy Periodontitis Radiation Radio Waves Rats Rats, Wistar Root canal therapy Root Canal Therapy - methods Root canals Teeth Transforming Growth Factor beta1 - metabolism University graduates Waves X-Ray Microtomography |
| title | Assessment of the functional efficacy of root canal treatment with high-frequency waves in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T04%3A19%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessment%20of%20the%20functional%20efficacy%20of%20root%20canal%20treatment%20with%20high-frequency%20waves%20in%20rats&rft.jtitle=PloS%20one&rft.au=Matsui,%20Saori&rft.date=2020-09-29&rft.volume=15&rft.issue=9&rft.spage=e0239660&rft.epage=e0239660&rft.pages=e0239660-e0239660&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0239660&rft_dat=%3Cgale_plos_%3EA636883564%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2447246278&rft_id=info:pmid/32991601&rft_galeid=A636883564&rft_doaj_id=oai_doaj_org_article_40fc48eae168447d9c9638373d24aa31&rfr_iscdi=true |