Effects of an anti-IGF-1 receptor monoclonal antibody on laminitis induced by prolonged hyperinsulinaemia in Standardbred horses

Currently, there are no registered veterinary drugs for the treatment of endocrinopathic equine laminitis, and although this form of the disease is known to be caused by prolonged hyperinsulinaemia, the mechanism of insulin toxicity is unclear. One possibility is that high concentrations of insulin...

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Veröffentlicht in:	PloS one 2020-09, Vol.15 (9), p.e0239261-e0239261
Hauptverfasser:	Rahnama, Samira, Vathsangam, Niveditha, Spence, Robert, Medina-Torres, Carlos E, Pollitt, Christopher C, de Laat, Melody A, Bailey, Simon R, Sillence, Martin N
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Biology Biology and Life Sciences Cell growth Cell proliferation Drug therapy Elongation Environmental science Feet Finger Gene expression Glucose Health aspects Horses Hypotheses Insulin Insulin-like growth factor I Laboratories Lamellae Laminitis Medicine and Health Sciences Monoclonal antibodies People and Places Physical Sciences Physiology Radiographs Radiography Receptors Statistical analysis Toxicity Veterinary medicine
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