Bio-activating ultrafine grain titanium: RNA sequencing reveals enhanced mechano-activation of osteoconduction on nanostructured substrates

Titanium is essentially absent from biological systems yet reliably integrates into bone. To achieve osseointegration, titanium must activate biological processes without entering cells, defining it as a bio-activating material. Nanostructuring bulk titanium reduces grain size, increases strength, a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2020-09, Vol.15 (9), p.e0237463
Hauptverfasser:	Reiss, Rebecca A, Lowe, Terry C, Sena, Johnny A, Makhnin, Oleg, Connick, Melanie C, Illescas, Patrick E, Davis, Casey F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biocompatibility Biocompatible Materials - chemistry Biological activity Biological clocks Biological properties Biology Biology and Life Sciences Biomedical materials Bone Regeneration Cell cycle Cell growth Cell Line Chromatin remodeling Circadian rhythm Circadian rhythms Coding Collagen Gene expression Gene sequencing Genes Genetic aspects Genomes Grain boundaries Grain size Growth factors Health aspects Identification and classification Immune response Materials science Materials Testing Mechanotransduction Mechanotransduction, Cellular Metabolism Methods Mice MicroRNAs Mines Nanostructure Nanostructures - chemistry Non-coding RNA Osseointegration Osteoblasts Osteoblasts - cytology Osteoblasts - metabolism Osteoconduction Phosphatase Physical properties Physiological aspects Proteins Research and analysis methods Ribonucleic acid RNA RNA modification RNA sequencing Sequence Analysis, RNA Stem cells Substrates Substrates (Biochemistry) Surface Properties Telomeres Titanium Titanium - chemistry Transcription factors Transcriptome Transcriptomics Transplants & implants Tumor suppressor genes Tumors Ultrafines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!