Study of reference intervals for free triiodothyronine, free thyroxine, and thyroid-stimulating hormone in an elderly Chinese Han population
The clinical manifestations of thyroid diseases in elderly patients are often atypical. This study aimed to establish reference intervals for thyroid function in the elderly in order to help diagnose thyroid diseases in this population. A total of 5345 healthy individuals were examined and divided i...
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| Veröffentlicht in: | PloS one 2020-09, Vol.15 (9), p.e0239579-e0239579 |
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| creator | Xiong, Jingting Liu, Shiguo Hu, Kai Xiong, Yinxiang Wang, Pengyun Xiong, Liang |
| description | The clinical manifestations of thyroid diseases in elderly patients are often atypical. This study aimed to establish reference intervals for thyroid function in the elderly in order to help diagnose thyroid diseases in this population. A total of 5345 healthy individuals were examined and divided into three groups according to their age: 4297 individuals aged < 65 years (19-64), 719 individuals aged between 65 and 79 years, and 329 individuals aged between 80 and 100 years. Levels of free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody, and thyroglobulin antibody were measured in these subjects by using a fully automated analyzer. The following free triiodothyronine, free thyroxine, and thyroid-stimulating hormone reference intervals were obtained from each age group: For individuals aged < 65 years (19-64 years), FT3, FT4, and TSH were 3.40-6.44, 10.26-19.25 pmol/L and 0.50-4.81 [mu]IU/mL, respectively. For individuals aged between 65 and 79 years, FT3, FT4 and TSH ranged between 3.01-5.91, 10.04-19.76 pmol/L, and 0.54-5.51 [mu]IU/mL, respectively. For individuals aged between 80 and 100 years, FT3, FT4, and TSH varied between 2.82-5.57, 9.79-21.22 pmol/L, 0.31-6.28 [mu]IU/mL respectively. FT3 concentration was lower and the concentrations of FT4 and TSH were higher in individuals aged [greater than or equal to] 65 years than in those aged |
| doi_str_mv | 10.1371/journal.pone.0239579 |
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This study aimed to establish reference intervals for thyroid function in the elderly in order to help diagnose thyroid diseases in this population. A total of 5345 healthy individuals were examined and divided into three groups according to their age: 4297 individuals aged < 65 years (19-64), 719 individuals aged between 65 and 79 years, and 329 individuals aged between 80 and 100 years. Levels of free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody, and thyroglobulin antibody were measured in these subjects by using a fully automated analyzer. The following free triiodothyronine, free thyroxine, and thyroid-stimulating hormone reference intervals were obtained from each age group: For individuals aged < 65 years (19-64 years), FT3, FT4, and TSH were 3.40-6.44, 10.26-19.25 pmol/L and 0.50-4.81 [mu]IU/mL, respectively. For individuals aged between 65 and 79 years, FT3, FT4 and TSH ranged between 3.01-5.91, 10.04-19.76 pmol/L, and 0.54-5.51 [mu]IU/mL, respectively. For individuals aged between 80 and 100 years, FT3, FT4, and TSH varied between 2.82-5.57, 9.79-21.22 pmol/L, 0.31-6.28 [mu]IU/mL respectively. FT3 concentration was lower and the concentrations of FT4 and TSH were higher in individuals aged [greater than or equal to] 65 years than in those aged <65 years (P<0.0001; P = 0.0039; P<0.0001, respectively). In conclusion, establishment of a reference interval would allow clinicians to diagnose diseases more accurately and easily.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0239579</identifier><identifier>PMID: 32970739</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Age groups ; Aging ; Antibodies ; Biology and Life Sciences ; Elderly patients ; Han (Chinese people) ; Hormones ; Hospitals ; Intervals ; Iodide peroxidase ; Laboratories ; Medical diagnosis ; Medical examination ; Medical research ; Medical schools ; Medicine ; Medicine and Health Sciences ; Methods ; Normal distribution ; Older people ; People and Places ; Peroxidase ; Physical Sciences ; Population ; Research methodology ; Thyroglobulin ; Thyroid ; Thyroid diseases ; Thyroid function tests ; Thyroid gland ; Thyroid hormones ; Thyroid-stimulating hormone ; Thyroxine ; Triiodothyronine</subject><ispartof>PloS one, 2020-09, Vol.15 (9), p.e0239579-e0239579</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Xiong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Xiong et al 2020 Xiong et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c599t-3087d2c1e3d7a54c81d053fe0ab1ea637e8609b3d0868d7ce1a0b6e16d89903f3</citedby><cites>FETCH-LOGICAL-c599t-3087d2c1e3d7a54c81d053fe0ab1ea637e8609b3d0868d7ce1a0b6e16d89903f3</cites><orcidid>0000-0001-7121-4389</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7514062/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7514062/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids></links><search><contributor>Naitza, Silvia</contributor><creatorcontrib>Xiong, Jingting</creatorcontrib><creatorcontrib>Liu, Shiguo</creatorcontrib><creatorcontrib>Hu, Kai</creatorcontrib><creatorcontrib>Xiong, Yinxiang</creatorcontrib><creatorcontrib>Wang, Pengyun</creatorcontrib><creatorcontrib>Xiong, Liang</creatorcontrib><title>Study of reference intervals for free triiodothyronine, free thyroxine, and thyroid-stimulating hormone in an elderly Chinese Han population</title><title>PloS one</title><description>The clinical manifestations of thyroid diseases in elderly patients are often atypical. This study aimed to establish reference intervals for thyroid function in the elderly in order to help diagnose thyroid diseases in this population. A total of 5345 healthy individuals were examined and divided into three groups according to their age: 4297 individuals aged < 65 years (19-64), 719 individuals aged between 65 and 79 years, and 329 individuals aged between 80 and 100 years. Levels of free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody, and thyroglobulin antibody were measured in these subjects by using a fully automated analyzer. The following free triiodothyronine, free thyroxine, and thyroid-stimulating hormone reference intervals were obtained from each age group: For individuals aged < 65 years (19-64 years), FT3, FT4, and TSH were 3.40-6.44, 10.26-19.25 pmol/L and 0.50-4.81 [mu]IU/mL, respectively. For individuals aged between 65 and 79 years, FT3, FT4 and TSH ranged between 3.01-5.91, 10.04-19.76 pmol/L, and 0.54-5.51 [mu]IU/mL, respectively. For individuals aged between 80 and 100 years, FT3, FT4, and TSH varied between 2.82-5.57, 9.79-21.22 pmol/L, 0.31-6.28 [mu]IU/mL respectively. FT3 concentration was lower and the concentrations of FT4 and TSH were higher in individuals aged [greater than or equal to] 65 years than in those aged <65 years (P<0.0001; P = 0.0039; P<0.0001, respectively). In conclusion, establishment of a reference interval would allow clinicians to diagnose diseases more accurately and easily.</description><subject>Age groups</subject><subject>Aging</subject><subject>Antibodies</subject><subject>Biology and Life Sciences</subject><subject>Elderly patients</subject><subject>Han (Chinese people)</subject><subject>Hormones</subject><subject>Hospitals</subject><subject>Intervals</subject><subject>Iodide peroxidase</subject><subject>Laboratories</subject><subject>Medical diagnosis</subject><subject>Medical examination</subject><subject>Medical research</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Normal distribution</subject><subject>Older people</subject><subject>People and Places</subject><subject>Peroxidase</subject><subject>Physical Sciences</subject><subject>Population</subject><subject>Research 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of reference intervals for free triiodothyronine, free thyroxine, and thyroid-stimulating hormone in an elderly Chinese Han population</title><author>Xiong, Jingting ; Liu, Shiguo ; Hu, Kai ; Xiong, Yinxiang ; Wang, Pengyun ; Xiong, Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c599t-3087d2c1e3d7a54c81d053fe0ab1ea637e8609b3d0868d7ce1a0b6e16d89903f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age groups</topic><topic>Aging</topic><topic>Antibodies</topic><topic>Biology and Life Sciences</topic><topic>Elderly patients</topic><topic>Han (Chinese people)</topic><topic>Hormones</topic><topic>Hospitals</topic><topic>Intervals</topic><topic>Iodide peroxidase</topic><topic>Laboratories</topic><topic>Medical diagnosis</topic><topic>Medical examination</topic><topic>Medical research</topic><topic>Medical schools</topic><topic>Medicine</topic><topic>Medicine and Health 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one</jtitle><date>2020-09-24</date><risdate>2020</risdate><volume>15</volume><issue>9</issue><spage>e0239579</spage><epage>e0239579</epage><pages>e0239579-e0239579</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The clinical manifestations of thyroid diseases in elderly patients are often atypical. This study aimed to establish reference intervals for thyroid function in the elderly in order to help diagnose thyroid diseases in this population. A total of 5345 healthy individuals were examined and divided into three groups according to their age: 4297 individuals aged < 65 years (19-64), 719 individuals aged between 65 and 79 years, and 329 individuals aged between 80 and 100 years. Levels of free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody, and thyroglobulin antibody were measured in these subjects by using a fully automated analyzer. The following free triiodothyronine, free thyroxine, and thyroid-stimulating hormone reference intervals were obtained from each age group: For individuals aged < 65 years (19-64 years), FT3, FT4, and TSH were 3.40-6.44, 10.26-19.25 pmol/L and 0.50-4.81 [mu]IU/mL, respectively. For individuals aged between 65 and 79 years, FT3, FT4 and TSH ranged between 3.01-5.91, 10.04-19.76 pmol/L, and 0.54-5.51 [mu]IU/mL, respectively. For individuals aged between 80 and 100 years, FT3, FT4, and TSH varied between 2.82-5.57, 9.79-21.22 pmol/L, 0.31-6.28 [mu]IU/mL respectively. FT3 concentration was lower and the concentrations of FT4 and TSH were higher in individuals aged [greater than or equal to] 65 years than in those aged <65 years (P<0.0001; P = 0.0039; P<0.0001, respectively). In conclusion, establishment of a reference interval would allow clinicians to diagnose diseases more accurately and easily.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32970739</pmid><doi>10.1371/journal.pone.0239579</doi><tpages>e0239579</tpages><orcidid>https://orcid.org/0000-0001-7121-4389</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age groups Aging Antibodies Biology and Life Sciences Elderly patients Han (Chinese people) Hormones Hospitals Intervals Iodide peroxidase Laboratories Medical diagnosis Medical examination Medical research Medical schools Medicine Medicine and Health Sciences Methods Normal distribution Older people People and Places Peroxidase Physical Sciences Population Research methodology Thyroglobulin Thyroid Thyroid diseases Thyroid function tests Thyroid gland Thyroid hormones Thyroid-stimulating hormone Thyroxine Triiodothyronine |
| title | Study of reference intervals for free triiodothyronine, free thyroxine, and thyroid-stimulating hormone in an elderly Chinese Han population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T23%3A57%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Study%C2%A0of%C2%A0reference%C2%A0intervals%C2%A0for%C2%A0free%C2%A0triiodothyronine,%C2%A0free%C2%A0thyroxine,%C2%A0and%C2%A0thyroid-stimulating%C2%A0hormone%C2%A0in%C2%A0an%C2%A0elderly%C2%A0Chinese%C2%A0Han%C2%A0population&rft.jtitle=PloS%20one&rft.au=Xiong,%20Jingting&rft.date=2020-09-24&rft.volume=15&rft.issue=9&rft.spage=e0239579&rft.epage=e0239579&rft.pages=e0239579-e0239579&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0239579&rft_dat=%3Cgale_plos_%3EA636415930%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2445951651&rft_id=info:pmid/32970739&rft_galeid=A636415930&rft_doaj_id=oai_doaj_org_article_fab7dfb0b0144160a4356cb4108b3b60&rfr_iscdi=true |