Preoperative diagnoses and identification rates of unexpected gallbladder cancer
Unexpected gallbladder cancer (UGBC) is sometimes found in the resected gallbladder of patients during or after surgery. Some reports have indicated UGBC identification rates for all gallbladder surgeries, but scarce data are available for the UGBC identification rates for specific gallbladder disea...
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| description | Unexpected gallbladder cancer (UGBC) is sometimes found in the resected gallbladder of patients during or after surgery. Some reports have indicated UGBC identification rates for all gallbladder surgeries, but scarce data are available for the UGBC identification rates for specific gallbladder diseases. The present study was performed to clarify UGBC rates and the factors suspicious for UGBC categorized according to preoperative diagnoses, in patients undergoing laparoscopic cholecystectomy (LSC). We recorded data for all LSC surgeries performed in the Department of Surgery, Sada Hospital, Japan since 1991, and analyzed the 28-year data. We used the chi-square test and Kaplan-Meier analysis for this retrospective case-control study. The UGBC identification rate was 0.69% (63/9186 patients). The UGBC identification rates categorized according to the preoperative diagnoses were 1.3% (13/969) for acute cholecystitis, 2.4% (16/655) for benign tumor, 2.0% (28/1383) for chronic cholecystitis or cholecystitis, and 0.054% (3/5585) for cholecystolithiasis. The percentage of older patients ([greater than or equal to] 60 years) was significantly higher in UGBCs compared with cases finally diagnosed as benign in each group categorized according to the preoperative diagnoses (p[less than or equal to]0.0014), except for cholecystolithiasis. In cases pre-diagnosed as benign tumor, UGBCs were associated with higher rates of thickened gallbladder wall compared with benign tumor (69.2% vs. 27.9%, respectively; p = 0.0011). UGBCs pre-diagnosed as acute cholecystitis had higher T2-T4 rates (100% vs. 64.3%, respectively; p |
| doi_str_mv | 10.1371/journal.pone.0239178 |
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Some reports have indicated UGBC identification rates for all gallbladder surgeries, but scarce data are available for the UGBC identification rates for specific gallbladder diseases. The present study was performed to clarify UGBC rates and the factors suspicious for UGBC categorized according to preoperative diagnoses, in patients undergoing laparoscopic cholecystectomy (LSC). We recorded data for all LSC surgeries performed in the Department of Surgery, Sada Hospital, Japan since 1991, and analyzed the 28-year data. We used the chi-square test and Kaplan-Meier analysis for this retrospective case-control study. The UGBC identification rate was 0.69% (63/9186 patients). The UGBC identification rates categorized according to the preoperative diagnoses were 1.3% (13/969) for acute cholecystitis, 2.4% (16/655) for benign tumor, 2.0% (28/1383) for chronic cholecystitis or cholecystitis, and 0.054% (3/5585) for cholecystolithiasis. The percentage of older patients ([greater than or equal to] 60 years) was significantly higher in UGBCs compared with cases finally diagnosed as benign in each group categorized according to the preoperative diagnoses (p[less than or equal to]0.0014), except for cholecystolithiasis. In cases pre-diagnosed as benign tumor, UGBCs were associated with higher rates of thickened gallbladder wall compared with benign tumor (69.2% vs. 27.9%, respectively; p = 0.0011). UGBCs pre-diagnosed as acute cholecystitis had higher T2-T4 rates (100% vs. 64.3%, respectively; p<0.05) and lower survival rates (p = 0.0149) than UGBCs pre-diagnosed with chronic cholecystitis. UGBC identification rates depend on the preoperative diagnosis and range from 0.054% to 2.4%. Older age ([greater than or equal to] 60 years) could be related to UGBC, and a pre-diagnosis of acute cholecystitis might indicate more advanced cancer compared with a pre-diagnosis of chronic cholecystitis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0239178</identifier><identifier>PMID: 32946469</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Benign ; Biology and Life Sciences ; Blood tests ; Cancer ; Care and treatment ; Chi-square test ; Cholecystectomy ; Cholecystitis ; Diagnosis ; Disease ; Gallbladder ; Gallbladder cancer ; Gallbladder diseases ; Hospitals ; Identification ; Inflammation ; Laparoscopy ; Laparotomy ; Magnetic resonance imaging ; Medical diagnosis ; Medical prognosis ; Medicine and Health Sciences ; Patient outcomes ; Patients ; Polyps ; Risk factors ; Statistical analysis ; Statistical tests ; Statistics ; Surgeons ; Surgery ; Survival ; Tumors</subject><ispartof>PloS one, 2020-09, Vol.15 (9), p.e0239178-e0239178</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Fujiwara et al. 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Some reports have indicated UGBC identification rates for all gallbladder surgeries, but scarce data are available for the UGBC identification rates for specific gallbladder diseases. The present study was performed to clarify UGBC rates and the factors suspicious for UGBC categorized according to preoperative diagnoses, in patients undergoing laparoscopic cholecystectomy (LSC). We recorded data for all LSC surgeries performed in the Department of Surgery, Sada Hospital, Japan since 1991, and analyzed the 28-year data. We used the chi-square test and Kaplan-Meier analysis for this retrospective case-control study. The UGBC identification rate was 0.69% (63/9186 patients). The UGBC identification rates categorized according to the preoperative diagnoses were 1.3% (13/969) for acute cholecystitis, 2.4% (16/655) for benign tumor, 2.0% (28/1383) for chronic cholecystitis or cholecystitis, and 0.054% (3/5585) for cholecystolithiasis. 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Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujiwara, Kenji</au><au>Masatsugu, Toshihiro</au><au>Abe, Atsushi</au><au>Hirano, Tatsuya</au><au>Sada, Masayuki</au><au>Tan, Ker-Kan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative diagnoses and identification rates of unexpected gallbladder cancer</atitle><jtitle>PloS one</jtitle><date>2020-09-18</date><risdate>2020</risdate><volume>15</volume><issue>9</issue><spage>e0239178</spage><epage>e0239178</epage><pages>e0239178-e0239178</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Unexpected gallbladder cancer (UGBC) is sometimes found in the resected gallbladder of patients during or after surgery. Some reports have indicated UGBC identification rates for all gallbladder surgeries, but scarce data are available for the UGBC identification rates for specific gallbladder diseases. The present study was performed to clarify UGBC rates and the factors suspicious for UGBC categorized according to preoperative diagnoses, in patients undergoing laparoscopic cholecystectomy (LSC). We recorded data for all LSC surgeries performed in the Department of Surgery, Sada Hospital, Japan since 1991, and analyzed the 28-year data. We used the chi-square test and Kaplan-Meier analysis for this retrospective case-control study. The UGBC identification rate was 0.69% (63/9186 patients). The UGBC identification rates categorized according to the preoperative diagnoses were 1.3% (13/969) for acute cholecystitis, 2.4% (16/655) for benign tumor, 2.0% (28/1383) for chronic cholecystitis or cholecystitis, and 0.054% (3/5585) for cholecystolithiasis. The percentage of older patients ([greater than or equal to] 60 years) was significantly higher in UGBCs compared with cases finally diagnosed as benign in each group categorized according to the preoperative diagnoses (p[less than or equal to]0.0014), except for cholecystolithiasis. In cases pre-diagnosed as benign tumor, UGBCs were associated with higher rates of thickened gallbladder wall compared with benign tumor (69.2% vs. 27.9%, respectively; p = 0.0011). UGBCs pre-diagnosed as acute cholecystitis had higher T2-T4 rates (100% vs. 64.3%, respectively; p<0.05) and lower survival rates (p = 0.0149) than UGBCs pre-diagnosed with chronic cholecystitis. UGBC identification rates depend on the preoperative diagnosis and range from 0.054% to 2.4%. Older age ([greater than or equal to] 60 years) could be related to UGBC, and a pre-diagnosis of acute cholecystitis might indicate more advanced cancer compared with a pre-diagnosis of chronic cholecystitis.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32946469</pmid><doi>10.1371/journal.pone.0239178</doi><tpages>e0239178</tpages><orcidid>https://orcid.org/0000-0001-5900-9382</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Benign Biology and Life Sciences Blood tests Cancer Care and treatment Chi-square test Cholecystectomy Cholecystitis Diagnosis Disease Gallbladder Gallbladder cancer Gallbladder diseases Hospitals Identification Inflammation Laparoscopy Laparotomy Magnetic resonance imaging Medical diagnosis Medical prognosis Medicine and Health Sciences Patient outcomes Patients Polyps Risk factors Statistical analysis Statistical tests Statistics Surgeons Surgery Survival Tumors |
| title | Preoperative diagnoses and identification rates of unexpected gallbladder cancer |
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