Relationship of self-reported body size and shape with risk for prostate cancer: A UK case-control study
Previous evidence has suggested a relationship between male self-reported body size and the risk of developing prostate cancer. In this UK-wide case-control study, we have explored the possible association of prostate cancer risk with male self-reported body size. We also investigated body shape as...
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Veröffentlicht in: | PloS one 2020-09, Vol.15 (9), p.e0238928 |
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creator | Aladwani, Mohammad Lophatananon, Artitaya Robinson, Fredie Rahman, Aneela Ollier, William Kote-Jarai, Zsofia Dearnaley, David Koveela, Govindasami Hussain, Nafisa Rageevakumar, Reshma Keating, Diana Osborne, Andrea Dadaev, Tokhir Brook, Mark Eeles, Rosalind Muir, Kenneth R |
description | Previous evidence has suggested a relationship between male self-reported body size and the risk of developing prostate cancer. In this UK-wide case-control study, we have explored the possible association of prostate cancer risk with male self-reported body size. We also investigated body shape as a surrogate marker for fat deposition around the body. As obesity and excessive adiposity have been linked with increased risk for developing a number of different cancers, further investigation of self-reported body size and shape and their potential relationship with prostate cancer was considered to be appropriate.
The study objective was to investigate whether underlying associations exist between prostate cancer risk and male self-reported body size and shape.
Data were collected from a large case-control study of men (1928 cases and 2043 controls) using self-administered questionnaires. Data from self-reported pictograms of perceived body size relating to three decades of life (20's, 30's and 40's) were recorded and analysed, including the pattern of change. The associations of self-identified body shape with prostate cancer risk were also explored.
Self-reported body size for men in their 20's, 30's and 40's did not appear to be associated with prostate cancer risk. More than half of the subjects reported an increase in self-reported body size throughout these three decades of life. Furthermore, no association was observed between self-reported body size changes and prostate cancer risk. Using 'symmetrical' body shape as a reference group, subjects with an 'apple' shape showed a significant 27% reduction in risk (Odds ratio = 0.73, 95% C.I. 0.57-0.92).
Change in self-reported body size throughout early to mid-adulthood in males is not a significant risk factor for the development of prostate cancer. Body shape indicative of body fat distribution suggested that an 'apple' body shape was protective and inversely associated with prostate cancer risk when compared with 'symmetrical' shape. Further studies which investigate prostate cancer risk and possible relationships with genetic factors known to influence body shape may shed further light on any underlying associations. |
doi_str_mv | 10.1371/journal.pone.0238928 |
format | Article |
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The study objective was to investigate whether underlying associations exist between prostate cancer risk and male self-reported body size and shape.
Data were collected from a large case-control study of men (1928 cases and 2043 controls) using self-administered questionnaires. Data from self-reported pictograms of perceived body size relating to three decades of life (20's, 30's and 40's) were recorded and analysed, including the pattern of change. The associations of self-identified body shape with prostate cancer risk were also explored.
Self-reported body size for men in their 20's, 30's and 40's did not appear to be associated with prostate cancer risk. More than half of the subjects reported an increase in self-reported body size throughout these three decades of life. Furthermore, no association was observed between self-reported body size changes and prostate cancer risk. Using 'symmetrical' body shape as a reference group, subjects with an 'apple' shape showed a significant 27% reduction in risk (Odds ratio = 0.73, 95% C.I. 0.57-0.92).
Change in self-reported body size throughout early to mid-adulthood in males is not a significant risk factor for the development of prostate cancer. Body shape indicative of body fat distribution suggested that an 'apple' body shape was protective and inversely associated with prostate cancer risk when compared with 'symmetrical' shape. Further studies which investigate prostate cancer risk and possible relationships with genetic factors known to influence body shape may shed further light on any underlying associations.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0238928</identifier><identifier>PMID: 32941451</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adipose tissue ; Adult ; Adults ; Age ; Aged ; Aged, 80 and over ; Biology ; Biology and Life Sciences ; Body constitution ; Body fat ; Body Mass Index ; Body Size ; Body weights and measures ; Cancer ; Case studies ; Case-Control Studies ; Data collection ; Genetic aspects ; Genetic factors ; Genetics ; Health aspects ; Health risks ; Health sciences ; Health services ; Human body ; Humans ; Male ; Males ; Medical research ; Medicine ; Medicine and Health Sciences ; Men ; Middle Aged ; Obesity ; Pattern analysis ; Population ; Primary care ; Prostate cancer ; Prostatic Neoplasms - epidemiology ; Questionnaires ; Risk analysis ; Risk Factors ; Self Report ; Social classes ; United Kingdom - epidemiology</subject><ispartof>PloS one, 2020-09, Vol.15 (9), p.e0238928</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Aladwani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Aladwani et al 2020 Aladwani et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c641t-eb1f4230ddc57e706c64d15c951264d7121e61e4a0f068b81c7e8a55d46eb6e83</cites><orcidid>0000-0003-0550-4657 ; 0000-0002-8268-0438 ; 0000-0003-0785-460X ; 0000-0002-7472-5384 ; 0000-0001-6429-988X ; 0000-0002-8969-2378</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498010/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498010/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27323,27903,27904,33753,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32941451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Rohrmann, Sabine</contributor><creatorcontrib>Aladwani, Mohammad</creatorcontrib><creatorcontrib>Lophatananon, Artitaya</creatorcontrib><creatorcontrib>Robinson, Fredie</creatorcontrib><creatorcontrib>Rahman, Aneela</creatorcontrib><creatorcontrib>Ollier, William</creatorcontrib><creatorcontrib>Kote-Jarai, Zsofia</creatorcontrib><creatorcontrib>Dearnaley, David</creatorcontrib><creatorcontrib>Koveela, Govindasami</creatorcontrib><creatorcontrib>Hussain, Nafisa</creatorcontrib><creatorcontrib>Rageevakumar, Reshma</creatorcontrib><creatorcontrib>Keating, Diana</creatorcontrib><creatorcontrib>Osborne, Andrea</creatorcontrib><creatorcontrib>Dadaev, Tokhir</creatorcontrib><creatorcontrib>Brook, Mark</creatorcontrib><creatorcontrib>Eeles, Rosalind</creatorcontrib><creatorcontrib>Muir, Kenneth R</creatorcontrib><creatorcontrib>British Association of Urological Surgeons’ Section of Oncology</creatorcontrib><title>Relationship of self-reported body size and shape with risk for prostate cancer: A UK case-control study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Previous evidence has suggested a relationship between male self-reported body size and the risk of developing prostate cancer. In this UK-wide case-control study, we have explored the possible association of prostate cancer risk with male self-reported body size. We also investigated body shape as a surrogate marker for fat deposition around the body. As obesity and excessive adiposity have been linked with increased risk for developing a number of different cancers, further investigation of self-reported body size and shape and their potential relationship with prostate cancer was considered to be appropriate.
The study objective was to investigate whether underlying associations exist between prostate cancer risk and male self-reported body size and shape.
Data were collected from a large case-control study of men (1928 cases and 2043 controls) using self-administered questionnaires. Data from self-reported pictograms of perceived body size relating to three decades of life (20's, 30's and 40's) were recorded and analysed, including the pattern of change. The associations of self-identified body shape with prostate cancer risk were also explored.
Self-reported body size for men in their 20's, 30's and 40's did not appear to be associated with prostate cancer risk. More than half of the subjects reported an increase in self-reported body size throughout these three decades of life. Furthermore, no association was observed between self-reported body size changes and prostate cancer risk. Using 'symmetrical' body shape as a reference group, subjects with an 'apple' shape showed a significant 27% reduction in risk (Odds ratio = 0.73, 95% C.I. 0.57-0.92).
Change in self-reported body size throughout early to mid-adulthood in males is not a significant risk factor for the development of prostate cancer. Body shape indicative of body fat distribution suggested that an 'apple' body shape was protective and inversely associated with prostate cancer risk when compared with 'symmetrical' shape. Further studies which investigate prostate cancer risk and possible relationships with genetic factors known to influence body shape may shed further light on any underlying associations.</description><subject>Adipose tissue</subject><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biology</subject><subject>Biology and Life Sciences</subject><subject>Body constitution</subject><subject>Body fat</subject><subject>Body Mass Index</subject><subject>Body Size</subject><subject>Body weights and measures</subject><subject>Cancer</subject><subject>Case studies</subject><subject>Case-Control Studies</subject><subject>Data collection</subject><subject>Genetic aspects</subject><subject>Genetic factors</subject><subject>Genetics</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Health sciences</subject><subject>Health services</subject><subject>Human body</subject><subject>Humans</subject><subject>Male</subject><subject>Males</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Pattern analysis</subject><subject>Population</subject><subject>Primary care</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Questionnaires</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Self Report</subject><subject>Social classes</subject><subject>United Kingdom - 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aladwani, Mohammad</au><au>Lophatananon, Artitaya</au><au>Robinson, Fredie</au><au>Rahman, Aneela</au><au>Ollier, William</au><au>Kote-Jarai, Zsofia</au><au>Dearnaley, David</au><au>Koveela, Govindasami</au><au>Hussain, Nafisa</au><au>Rageevakumar, Reshma</au><au>Keating, Diana</au><au>Osborne, Andrea</au><au>Dadaev, Tokhir</au><au>Brook, Mark</au><au>Eeles, Rosalind</au><au>Muir, Kenneth R</au><au>Rohrmann, Sabine</au><aucorp>British Association of Urological Surgeons’ Section of Oncology</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of self-reported body size and shape with risk for prostate cancer: A UK case-control study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-09-17</date><risdate>2020</risdate><volume>15</volume><issue>9</issue><spage>e0238928</spage><pages>e0238928-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Previous evidence has suggested a relationship between male self-reported body size and the risk of developing prostate cancer. In this UK-wide case-control study, we have explored the possible association of prostate cancer risk with male self-reported body size. We also investigated body shape as a surrogate marker for fat deposition around the body. As obesity and excessive adiposity have been linked with increased risk for developing a number of different cancers, further investigation of self-reported body size and shape and their potential relationship with prostate cancer was considered to be appropriate.
The study objective was to investigate whether underlying associations exist between prostate cancer risk and male self-reported body size and shape.
Data were collected from a large case-control study of men (1928 cases and 2043 controls) using self-administered questionnaires. Data from self-reported pictograms of perceived body size relating to three decades of life (20's, 30's and 40's) were recorded and analysed, including the pattern of change. The associations of self-identified body shape with prostate cancer risk were also explored.
Self-reported body size for men in their 20's, 30's and 40's did not appear to be associated with prostate cancer risk. More than half of the subjects reported an increase in self-reported body size throughout these three decades of life. Furthermore, no association was observed between self-reported body size changes and prostate cancer risk. Using 'symmetrical' body shape as a reference group, subjects with an 'apple' shape showed a significant 27% reduction in risk (Odds ratio = 0.73, 95% C.I. 0.57-0.92).
Change in self-reported body size throughout early to mid-adulthood in males is not a significant risk factor for the development of prostate cancer. Body shape indicative of body fat distribution suggested that an 'apple' body shape was protective and inversely associated with prostate cancer risk when compared with 'symmetrical' shape. Further studies which investigate prostate cancer risk and possible relationships with genetic factors known to influence body shape may shed further light on any underlying associations.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32941451</pmid><doi>10.1371/journal.pone.0238928</doi><tpages>e0238928</tpages><orcidid>https://orcid.org/0000-0003-0550-4657</orcidid><orcidid>https://orcid.org/0000-0002-8268-0438</orcidid><orcidid>https://orcid.org/0000-0003-0785-460X</orcidid><orcidid>https://orcid.org/0000-0002-7472-5384</orcidid><orcidid>https://orcid.org/0000-0001-6429-988X</orcidid><orcidid>https://orcid.org/0000-0002-8969-2378</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1932-6203 |
ispartof | PloS one, 2020-09, Vol.15 (9), p.e0238928 |
issn | 1932-6203 1932-6203 |
language | eng |
recordid | cdi_plos_journals_2443875143 |
source | MEDLINE; DOAJ Directory of Open Access Journals; Sociological Abstracts; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
subjects | Adipose tissue Adult Adults Age Aged Aged, 80 and over Biology Biology and Life Sciences Body constitution Body fat Body Mass Index Body Size Body weights and measures Cancer Case studies Case-Control Studies Data collection Genetic aspects Genetic factors Genetics Health aspects Health risks Health sciences Health services Human body Humans Male Males Medical research Medicine Medicine and Health Sciences Men Middle Aged Obesity Pattern analysis Population Primary care Prostate cancer Prostatic Neoplasms - epidemiology Questionnaires Risk analysis Risk Factors Self Report Social classes United Kingdom - epidemiology |
title | Relationship of self-reported body size and shape with risk for prostate cancer: A UK case-control study |
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