Single-step extraction for simultaneous quantification of desvenlafaxine and alprazolam in human spiked plasma by RP-HPLC

Desvenlafaxine (DES) and Alprazolam (ALP) are the drugs commonly prescribed together for the treatment of Major Depressive Disorders (MDD). A literature survey revealed, there is no method for the simultaneous determination of these two drugs. The purpose of this research was to develop and validate...

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Veröffentlicht in:	PloS one 2020-09, Vol.15 (9), p.e0238954-e0238954
Hauptverfasser:	Rao, Huma, Ahmad, Saeed, Madni, Asadullah, Ahmad, Imtiaz, Shahzad, Muhammad Nadeem
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Acetonitrile Alprazolam Anxiety Biology and Life Sciences Chromatography Desvenlafaxine Drug dosages Drugs Elution Flow velocity High performance liquid chromatography Ions Liquid chromatography Literature reviews Measurement Medicine and Health Sciences Membrane filters Mental depression Mental disorders Methods Parameters Pharmacokinetics Pharmacy Physical Sciences Physiological aspects Plasma Pore size Potash Potassium Potassium phosphate Potassium phosphates Research and Analysis Methods Robustness Sleep
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