High-resolution analysis of Merkel Cell Polyomavirus in Merkel Cell Carcinoma reveals distinct integration patterns and suggests NHEJ and MMBIR as underlying mechanisms

Merkel Cell Polyomavirus (MCPyV) is the etiological agent of the majority of Merkel Cell Carcinomas (MCC). MCPyV positive MCCs harbor integrated, defective viral genomes that constitutively express viral oncogenes. Which molecular mechanisms promote viral integration, if distinct integration pattern...

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Veröffentlicht in:	PLoS pathogens 2020-08, Vol.16 (8), p.e1008562
Hauptverfasser:	Czech-Sioli, Manja, Günther, Thomas, Therre, Marlin, Spohn, Michael, Indenbirken, Daniela, Theiss, Juliane, Riethdorf, Sabine, Qi, Minyue, Alawi, Malik, Wülbeck, Corinna, Fernandez-Cuesta, Irene, Esmek, Franziska, Becker, Jürgen C., Grundhoff, Adam, Fischer, Nicole
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioinformatics Biology and Life Sciences Breakpoints Carcinoma Causes of Chromatin Consortia Deoxyribonucleic acid DNA DNA damage DNA viruses Epigenetics Etiology Gene sequencing Gene therapy Genetic aspects Genomes Health aspects High resolution Homology Hygiene Integration Loci Medical research Medicine and Health Sciences Merkel cell carcinoma Metastasis Molecular modelling Mutation Next-generation sequencing Non-homologous end joining Nucleotide sequence Oncogenes Papillomaviridae Polyomavirus Porosity Proteins Replication Research and Analysis Methods Ribonucleic acid RNA Sequence analysis Skin cancer Software Solid state physics Transcription Tumors Virology Viruses
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