Fixed vs adjusted-dose benznidazole for adults with chronic Chagas disease without cardiomyopathy: A systematic review and meta-analysis

Chagas disease is a neglected disease that remains a public health threat, particularly in Latin America. The most important treatment options are nitroimidazole derivatives, such as nifurtimox and benznidazole (BZN). Some studies suggest that for adults seropositive to T. cruzi but without clinical...

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Veröffentlicht in:	PLoS neglected tropical diseases 2020-08, Vol.14 (8), p.e0008529
Hauptverfasser:	Ciapponi, Agustín, Barreira, Fabiana, Perelli, Lucas, Bardach, Ariel, Gascón, Joaquim, Molina, Israel, Morillo, Carlos, Prado, Nilda, Riarte, Adelina, Torrico, Faustino, Ribeiro, Isabela, Villar, Juan Carlos, Sosa-Estani, Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Analysis Asymptomatic Benznidazole Bias Biology and Life Sciences Blood & organ donations Cardiomyopathies Cardiomyopathy Chagas disease Chagas Disease - drug therapy Chronic illnesses Clinical trials Comparative analysis Databases, Factual Diseases DNA Dosage and administration Drug administration and dosage Drug dosages Drug therapy Equivalence Health risks Humans Infections Investigations Medicine and Health Sciences Meta-analysis Nifurtimox Nifurtimox - therapeutic use Nitroimidazole Nitroimidazoles - administration & dosage Nitroimidazoles - therapeutic use Nucleotide sequence Parasites Patient Safety Patients PCR Peripheral neuropathy Physical Sciences Population Public health Randomized Controlled Trials as Topic Research and Analysis Methods Safety Serology Software Subgroups Systematic review Treatment Outcome Triazoles - therapeutic use Tropical diseases Trypanosoma cruzi - drug effects Vector-borne diseases
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