Liver damage in schistosomiasis is reduced by adipose tissue-derived stem cell therapy after praziquantel treatment

Background In view of the potential immunosuppressive and regenerative properties of mesenchymal stem cells (MSC), we investigated whether transplantation of adipose tissue-derived stem cells (ASC) could be used to control the granulomatous reaction in the liver of mice infected with Schistosoma man...

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Veröffentlicht in:	PLoS neglected tropical diseases 2020-08, Vol.14 (8), p.e0008635-e0008635
Hauptverfasser:	Miranda, Vitor Hugo Simões, Gomes, Talita Rocha, Eller, Dirli Emerick, Ferraz, Lorena de Cássia Neres, Chaves, Ana Thereza, Bicalho, Kelly Alves, Silva, Carlos Eduardo Calzavara, Birbrair, Alexander, Pascoal Xavier, Marcelo Antônio, de Goes, Alfredo Miranda, Corrêa-Oliveira, Rodrigo, Alves, Érica Alessandra Rocha, Bozzi, Adriana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Biology and Life Sciences Body fat CD28 antigen CD4 antigen Cell therapy Cells Chronic infection Cloning Complications and side effects CTLA-4 protein Cytokines Damage Drug therapy Eggs Granulomas Immunology Infections Inflammation Interleukin 10 Interleukin 17 Lesions Liver Liver diseases Lymphocytes Lymphocytes T Medicine and Health Sciences Mesenchymal stem cells Mesenchyme Molecules Parasitic diseases Patient outcomes Praziquantel Prevention Schistosoma mansoni Schistosomiasis Stem cell transplantation Stem cells Therapy Transplantation Tropical diseases Tumor necrosis factor-TNF
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