Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza

Pandemic influenza A virus (IAV) remains a significant threat to global health. Preparedness relies primarily upon a single class of neuraminidase (NA) targeted antivirals, against which resistance is steadily growing. The M2 proton channel is an alternative clinically proven antiviral target, yet a...

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Veröffentlicht in:	PLoS pathogens 2020-08, Vol.16 (8), p.e1008716
Hauptverfasser:	Scott, Claire, Kankanala, Jayakanth, Foster, Toshana L, Goldhill, Daniel H, Bao, Peng, Simmons, Katie, Pingen, Marieke, Bentham, Matthew, Atkins, Elizabeth, Loundras, Eleni, Elderfield, Ruth, Claridge, Jolyon K, Thompson, Joseph, Stilwell, Peter R, Tathineni, Ranjitha, McKimmie, Clive S, Targett-Adams, Paul, Schnell, Jason R, Cook, Graham P, Evans, Stephen, Barclay, Wendy S, Foster, Richard, Griffin, Stephen, Lowen, Anice C, Pekosz, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral agents Antiviral drugs Biochemistry Biology and Life Sciences Care and treatment Chemistry College campuses Combination drug therapy Combination therapy Development and progression Drug resistance Enzyme inhibitors Exo-a-sialidase Funding Genetic aspects Global health Health aspects Health risks Hospitals Influenza Influenza A Inhibitors Livestock Mathematics Medical research Medicine Medicine and Health Sciences Methods Molecular biology Pandemics Patient outcomes Peptides Physical Sciences Polymorphism Protons Public health Risk reduction Supervision Swine Swine flu Virology Viruses Zanamivir
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