Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping

Pleiotropy-when a single mutation affects multiple traits-is a controversial topic with far-reaching implications. Pleiotropy plays a central role in debates about how complex traits evolve and whether biological systems are modular or are organized such that every gene has the potential to affect m...

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Veröffentlicht in:PLoS biology 2020-08, Vol.18 (8), p.e3000836-e3000836
Hauptverfasser: Geiler-Samerotte, Kerry A, Li, Shuang, Lazaris, Charalampos, Taylor, Austin, Ziv, Naomi, Ramjeawan, Chelsea, Paaby, Annalise B, Siegal, Mark L
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Sprache:eng
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