The roles of replication-transcription conflict in mutagenesis and evolution of genome organization

Replication-transcription conflicts promote mutagenesis and give rise to evolutionary signatures, with fundamental importance to genome stability ranging from bacteria to metastatic cancer cells. This review focuses on the interplay between replication-transcription conflicts and the evolution of ge...

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Veröffentlicht in:	PLoS genetics 2020-08, Vol.16 (8), p.e1008987
Hauptverfasser:	Schroeder, Jeremy W, Sankar, T Sabari, Wang, Jue D, Simmons, Lyle A
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Bacteria - genetics Bacteriology Bias Biology and life sciences Deoxyribonucleic acid DNA DNA biosynthesis DNA replication DNA Replication - genetics E coli Evolution & development Evolution, Molecular Evolutionary genetics Gene expression Genes Genetic research Genome, Bacterial - genetics Genomes Genomics Hypotheses Medicine and Health Sciences Metastases Mutagenesis Mutation Natural selection Negative selection Replication Research and Analysis Methods Review Science education Selection, Genetic - genetics Transcription Transcription (Genetics) Transcription, Genetic
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