A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein

Apolipoprotein B-containing lipoproteins (B-lps) are essential for the transport of hydrophobic dietary and endogenous lipids through the circulation in vertebrates. Zebrafish embryos produce large numbers of B-lps in the yolk syncytial layer (YSL) to move lipids from yolk to growing tissues. Disrup...

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Veröffentlicht in:	PLoS genetics 2020-08, Vol.16 (8), p.e1008941-e1008941
Hauptverfasser:	Wilson, Meredith H, Rajan, Sujith, Danoff, Aidan, White, Richard J, Hensley, Monica R, Quinlivan, Vanessa H, Recacha, Rosario, Thierer, James H, Tan, Frederick J, Busch-Nentwich, Elisabeth M, Ruddock, Lloyd, Hussain, M Mahmood, Farber, Steven A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoprotein B Apolipoproteins Biology and Life Sciences Carrier Proteins - genetics Crystal structure Danio rerio Drug development Dyslipidemia Embryos Fatty Liver - genetics Fatty Liver - pathology Gastrointestinal Tract - metabolism Gene mutation Glycine Humans Hydrophobicity Immunoprecipitation Intestine Lipid Droplets - metabolism Lipids Lipids - genetics Lipoproteins Lipoproteins - genetics Lipoproteins - metabolism Malabsorption Medicine and Health Sciences Metabolic disorders Missense mutation Mutants Mutation Mutation, Missense - genetics Observations Phenotypes Phospholipids Physiological aspects Point mutation Point Mutation - genetics Protein transport Protein Transport - genetics Research and Analysis Methods Triglycerides Triglycerides - genetics Triglycerides - metabolism Valine Yolk Zebrafish Zebrafish - genetics
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