Zinc-finger antiviral protein (ZAP) is a restriction factor for replication of modified vaccinia virus Ankara (MVA) in human cells

Modified vaccinia virus Ankara (MVA) is an approved smallpox vaccine and a promising vaccine vector for other pathogens as well as for cancer therapeutics with more than 200 current or completed clinical trials. MVA was derived by passaging the parental Ankara vaccine virus hundreds of times in chic...

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Veröffentlicht in:	PLoS pathogens 2020-08, Vol.16 (8), p.e1008845-e1008845
Hauptverfasser:	Peng, Chen, Wyatt, Linda S, Glushakow-Smith, Shira G, Lal-Nag, Madhu, Weisberg, Andrea S, Moss, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Animals Biology and Life Sciences Chickens Clinical trials CRISPR Cytoplasm - metabolism Cytoplasm - virology Deactivation Deoxyribonucleic acid DNA DNA, Viral - genetics DNA, Viral - metabolism DNA-directed RNA polymerase Embryo fibroblasts Embryos Fibroblasts Gene Knockdown Techniques Gene sequencing Genes Genomes Humans Inactivation Infectious diseases Laboratories Mammalian cells Mass spectrometry Mass spectroscopy Medicine and Health Sciences Mice Morphogenesis mRNA Polymerase chain reaction Proteins Replication Repressor Proteins - genetics Repressor Proteins - metabolism Research and Analysis Methods Ribonucleic acid RNA RNA viruses RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Viral - genetics RNA, Viral - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism RNA-mediated interference RNA-Seq Sequestering Smallpox Vaccines Vaccinia virus - physiology Virions Virus Replication - physiology Viruses Zinc Zinc finger proteins
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