Prevalence and risk factors associated with Clonorchis sinensis infections in rural communities in northern Vietnam
Background Clonorchiasis, caused by the fish-borne trematode Clonorchis sinensis, is a neglected tropical disease and a public health issue in endemic countries. In Vietnam, an in-depth analysis of risk factors for the condition is missing up to now. This study aimed to determine the prevalence of C...
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| Veröffentlicht in: | PLoS neglected tropical diseases 2020-08, Vol.14 (8), p.e0008483 |
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| creator | Nguyen, Thao T. B. Dermauw, Veronique Dahma, Hafid Bui, Dung Thi Le, Trang T. H. Phi, Ngan T. T. Lempereur, Laetitia Losson, Bertrand Vandenberg, Olivier Do, Dung Trung Dorny, Pierre |
| description | Background Clonorchiasis, caused by the fish-borne trematode Clonorchis sinensis, is a neglected tropical disease and a public health issue in endemic countries. In Vietnam, an in-depth analysis of risk factors for the condition is missing up to now. This study aimed to determine the prevalence of C. sinensis infection and associated risk factors in rural communities in northern Vietnam. Methodology/Principal findings A cross-sectional survey was conducted in 4 communes in Yen Bai and Thanh Hoa provinces where clonorchiasis is known to be present and raw fish consumption is a common. Using a simple random sampling approach, stool was collected from 841 participants over 6 years old for coprological examination, and a questionnaire measured knowledge, attitudes, and practices with regard to clonorchiasis in 757 participants over 15 years old. Univariable and multivariable logistic regression models were run to identify risk factors for infection with C. sinensis. The overall prevalence of C. sinensis infection was 40.4%, with commune prevalences ranging between 26.5% and 53.3%. In the final model, males were significantly more likely to be infected with C. sinensis (OR 2.00; 95% CI 1.31-3.05). Recent (i.e. last year) consumption of raw fish (OR 8.00, 95% CI 4.78-13.36), low education level (OR 5.57; 95% CI 2.37-13.07), lack of treatment (OR 1.82, 95% CI 1.15-2.89), being between 19 to 39 years old (OR 6.46; 95% CI 1.25-33.37), and the presence of an unhygienic toilet (OR 2.74, 95% CI 1.53-4.92) were significantly associated with C. sinensis infection. Conclusion/Significance This study demonstrated a high prevalence of C. sinensis infection in rural communities in northern Vietnam. Thus, control measures including, mass drug administration for those communes should be applied to reduce the prevalence. Moreover, specific health education activities should be developed for risk groups in C. sinensis endemic areas. |
| doi_str_mv | 10.1371/journal.pntd.0008483 |
| format | Article |
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B. ; Dermauw, Veronique ; Dahma, Hafid ; Bui, Dung Thi ; Le, Trang T. H. ; Phi, Ngan T. T. ; Lempereur, Laetitia ; Losson, Bertrand ; Vandenberg, Olivier ; Do, Dung Trung ; Dorny, Pierre</creator><creatorcontrib>Nguyen, Thao T. B. ; Dermauw, Veronique ; Dahma, Hafid ; Bui, Dung Thi ; Le, Trang T. H. ; Phi, Ngan T. T. ; Lempereur, Laetitia ; Losson, Bertrand ; Vandenberg, Olivier ; Do, Dung Trung ; Dorny, Pierre</creatorcontrib><description>Background Clonorchiasis, caused by the fish-borne trematode Clonorchis sinensis, is a neglected tropical disease and a public health issue in endemic countries. In Vietnam, an in-depth analysis of risk factors for the condition is missing up to now. This study aimed to determine the prevalence of C. sinensis infection and associated risk factors in rural communities in northern Vietnam. Methodology/Principal findings A cross-sectional survey was conducted in 4 communes in Yen Bai and Thanh Hoa provinces where clonorchiasis is known to be present and raw fish consumption is a common. Using a simple random sampling approach, stool was collected from 841 participants over 6 years old for coprological examination, and a questionnaire measured knowledge, attitudes, and practices with regard to clonorchiasis in 757 participants over 15 years old. Univariable and multivariable logistic regression models were run to identify risk factors for infection with C. sinensis. The overall prevalence of C. sinensis infection was 40.4%, with commune prevalences ranging between 26.5% and 53.3%. In the final model, males were significantly more likely to be infected with C. sinensis (OR 2.00; 95% CI 1.31-3.05). Recent (i.e. last year) consumption of raw fish (OR 8.00, 95% CI 4.78-13.36), low education level (OR 5.57; 95% CI 2.37-13.07), lack of treatment (OR 1.82, 95% CI 1.15-2.89), being between 19 to 39 years old (OR 6.46; 95% CI 1.25-33.37), and the presence of an unhygienic toilet (OR 2.74, 95% CI 1.53-4.92) were significantly associated with C. sinensis infection. Conclusion/Significance This study demonstrated a high prevalence of C. sinensis infection in rural communities in northern Vietnam. Thus, control measures including, mass drug administration for those communes should be applied to reduce the prevalence. Moreover, specific health education activities should be developed for risk groups in C. sinensis endemic areas.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0008483</identifier><identifier>PMID: 32745095</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Biology and Life Sciences ; Clonorchis sinensis ; Consumption ; Distribution ; Earth Sciences ; Education ; Fish ; Fish consumption ; Fluke infections ; Health risks ; Households ; Infections ; Investigations ; Laboratories ; Medical research ; Medicine and Health Sciences ; Oriental liver fluke ; Parasitic diseases ; Parasitology ; People and Places ; Population ; Provinces ; Public health ; Random sampling ; Regression analysis ; Regression models ; Risk analysis ; Risk factors ; Risk groups ; Rural areas ; Rural communities ; Rural health ; Social Sciences ; Statistical sampling ; Statistics ; Supervision ; Surveying ; Tropical climate ; Tropical diseases ; Veterinary medicine</subject><ispartof>PLoS neglected tropical diseases, 2020-08, Vol.14 (8), p.e0008483</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Nguyen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Nguyen et al 2020 Nguyen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-a25b21540cbf3b079d069053d1b110e15f4c4cad19cd77bff16f31c294bf71db3</citedby><cites>FETCH-LOGICAL-c562t-a25b21540cbf3b079d069053d1b110e15f4c4cad19cd77bff16f31c294bf71db3</cites><orcidid>0000-0001-8745-5304 ; 0000-0001-5326-1288</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425981/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425981/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids></links><search><creatorcontrib>Nguyen, Thao T. B.</creatorcontrib><creatorcontrib>Dermauw, Veronique</creatorcontrib><creatorcontrib>Dahma, Hafid</creatorcontrib><creatorcontrib>Bui, Dung Thi</creatorcontrib><creatorcontrib>Le, Trang T. H.</creatorcontrib><creatorcontrib>Phi, Ngan T. T.</creatorcontrib><creatorcontrib>Lempereur, Laetitia</creatorcontrib><creatorcontrib>Losson, Bertrand</creatorcontrib><creatorcontrib>Vandenberg, Olivier</creatorcontrib><creatorcontrib>Do, Dung Trung</creatorcontrib><creatorcontrib>Dorny, Pierre</creatorcontrib><title>Prevalence and risk factors associated with Clonorchis sinensis infections in rural communities in northern Vietnam</title><title>PLoS neglected tropical diseases</title><description>Background Clonorchiasis, caused by the fish-borne trematode Clonorchis sinensis, is a neglected tropical disease and a public health issue in endemic countries. In Vietnam, an in-depth analysis of risk factors for the condition is missing up to now. This study aimed to determine the prevalence of C. sinensis infection and associated risk factors in rural communities in northern Vietnam. Methodology/Principal findings A cross-sectional survey was conducted in 4 communes in Yen Bai and Thanh Hoa provinces where clonorchiasis is known to be present and raw fish consumption is a common. Using a simple random sampling approach, stool was collected from 841 participants over 6 years old for coprological examination, and a questionnaire measured knowledge, attitudes, and practices with regard to clonorchiasis in 757 participants over 15 years old. Univariable and multivariable logistic regression models were run to identify risk factors for infection with C. sinensis. The overall prevalence of C. sinensis infection was 40.4%, with commune prevalences ranging between 26.5% and 53.3%. In the final model, males were significantly more likely to be infected with C. sinensis (OR 2.00; 95% CI 1.31-3.05). Recent (i.e. last year) consumption of raw fish (OR 8.00, 95% CI 4.78-13.36), low education level (OR 5.57; 95% CI 2.37-13.07), lack of treatment (OR 1.82, 95% CI 1.15-2.89), being between 19 to 39 years old (OR 6.46; 95% CI 1.25-33.37), and the presence of an unhygienic toilet (OR 2.74, 95% CI 1.53-4.92) were significantly associated with C. sinensis infection. Conclusion/Significance This study demonstrated a high prevalence of C. sinensis infection in rural communities in northern Vietnam. Thus, control measures including, mass drug administration for those communes should be applied to reduce the prevalence. Moreover, specific health education activities should be developed for risk groups in C. sinensis endemic areas.</description><subject>Biology and Life Sciences</subject><subject>Clonorchis sinensis</subject><subject>Consumption</subject><subject>Distribution</subject><subject>Earth Sciences</subject><subject>Education</subject><subject>Fish</subject><subject>Fish consumption</subject><subject>Fluke infections</subject><subject>Health risks</subject><subject>Households</subject><subject>Infections</subject><subject>Investigations</subject><subject>Laboratories</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Oriental liver fluke</subject><subject>Parasitic diseases</subject><subject>Parasitology</subject><subject>People and Places</subject><subject>Population</subject><subject>Provinces</subject><subject>Public health</subject><subject>Random sampling</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Risk groups</subject><subject>Rural areas</subject><subject>Rural communities</subject><subject>Rural health</subject><subject>Social Sciences</subject><subject>Statistical sampling</subject><subject>Statistics</subject><subject>Supervision</subject><subject>Surveying</subject><subject>Tropical climate</subject><subject>Tropical diseases</subject><subject>Veterinary medicine</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp1kkuLFDEUhQtRnHH0HwgGBHfd5lmpbIShcXRgQBfqNqTy6EpblbRJasR_P-nuUqYXrnK4-XJyuPc2zWsE14hw9H4X5xTUuN6HYtYQwo525ElziQRhK8wJe_pIXzQvct5ByATr0PPmgmBOGRTssslfk71Xow3aAhUMSD7_BE7pElMGKueovSrWgN--DGAzxhCTHnwG2QcbchU-OKuLj-EgQZqTGoGO0zQHX7w9FuubMtgUwA9vS1DTy-aZU2O2r5bzqvl-8_Hb5vPq7sun28313UqzFpeVwqzHiFGoe0d6yIWBrYCMGNQjBC1ijmqqlUFCG85751DrCNJY0N5xZHpy1bw5-e7HmOXSrywxpYR1AnewErcnwkS1k_vkJ5X-yKi8PBZi2kqVitejlbhtHRMEWoId7RTpBba8oy3FtVKDVK8Py29zP1mjbSi1F2em5zfBD3Ib7yWnmIkOVYO3i0GKv2aby38iL9S2Tk3W7sdqpieftbxuCa0kRKxS7x5Rg1VjGXIc5-OgzkF6AnWKOSfr_gVGUB727G8IedgzuewZeQBbusfJ</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Nguyen, Thao T. 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T.</creator><creator>Lempereur, Laetitia</creator><creator>Losson, Bertrand</creator><creator>Vandenberg, Olivier</creator><creator>Do, Dung Trung</creator><creator>Dorny, Pierre</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T2</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8745-5304</orcidid><orcidid>https://orcid.org/0000-0001-5326-1288</orcidid></search><sort><creationdate>20200801</creationdate><title>Prevalence and risk factors associated with Clonorchis sinensis infections in rural communities in northern Vietnam</title><author>Nguyen, Thao T. B. ; Dermauw, Veronique ; Dahma, Hafid ; Bui, Dung Thi ; Le, Trang T. H. ; Phi, Ngan T. 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B.</au><au>Dermauw, Veronique</au><au>Dahma, Hafid</au><au>Bui, Dung Thi</au><au>Le, Trang T. H.</au><au>Phi, Ngan T. T.</au><au>Lempereur, Laetitia</au><au>Losson, Bertrand</au><au>Vandenberg, Olivier</au><au>Do, Dung Trung</au><au>Dorny, Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and risk factors associated with Clonorchis sinensis infections in rural communities in northern Vietnam</atitle><jtitle>PLoS neglected tropical diseases</jtitle><date>2020-08-01</date><risdate>2020</risdate><volume>14</volume><issue>8</issue><spage>e0008483</spage><pages>e0008483-</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>Background Clonorchiasis, caused by the fish-borne trematode Clonorchis sinensis, is a neglected tropical disease and a public health issue in endemic countries. In Vietnam, an in-depth analysis of risk factors for the condition is missing up to now. This study aimed to determine the prevalence of C. sinensis infection and associated risk factors in rural communities in northern Vietnam. Methodology/Principal findings A cross-sectional survey was conducted in 4 communes in Yen Bai and Thanh Hoa provinces where clonorchiasis is known to be present and raw fish consumption is a common. Using a simple random sampling approach, stool was collected from 841 participants over 6 years old for coprological examination, and a questionnaire measured knowledge, attitudes, and practices with regard to clonorchiasis in 757 participants over 15 years old. Univariable and multivariable logistic regression models were run to identify risk factors for infection with C. sinensis. The overall prevalence of C. sinensis infection was 40.4%, with commune prevalences ranging between 26.5% and 53.3%. In the final model, males were significantly more likely to be infected with C. sinensis (OR 2.00; 95% CI 1.31-3.05). Recent (i.e. last year) consumption of raw fish (OR 8.00, 95% CI 4.78-13.36), low education level (OR 5.57; 95% CI 2.37-13.07), lack of treatment (OR 1.82, 95% CI 1.15-2.89), being between 19 to 39 years old (OR 6.46; 95% CI 1.25-33.37), and the presence of an unhygienic toilet (OR 2.74, 95% CI 1.53-4.92) were significantly associated with C. sinensis infection. Conclusion/Significance This study demonstrated a high prevalence of C. sinensis infection in rural communities in northern Vietnam. Thus, control measures including, mass drug administration for those communes should be applied to reduce the prevalence. Moreover, specific health education activities should be developed for risk groups in C. sinensis endemic areas.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32745095</pmid><doi>10.1371/journal.pntd.0008483</doi><orcidid>https://orcid.org/0000-0001-8745-5304</orcidid><orcidid>https://orcid.org/0000-0001-5326-1288</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PLoS neglected tropical diseases, 2020-08, Vol.14 (8), p.e0008483 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access; Public Library of Science (PLoS) |
| subjects | Biology and Life Sciences Clonorchis sinensis Consumption Distribution Earth Sciences Education Fish Fish consumption Fluke infections Health risks Households Infections Investigations Laboratories Medical research Medicine and Health Sciences Oriental liver fluke Parasitic diseases Parasitology People and Places Population Provinces Public health Random sampling Regression analysis Regression models Risk analysis Risk factors Risk groups Rural areas Rural communities Rural health Social Sciences Statistical sampling Statistics Supervision Surveying Tropical climate Tropical diseases Veterinary medicine |
| title | Prevalence and risk factors associated with Clonorchis sinensis infections in rural communities in northern Vietnam |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T20%3A02%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20and%20risk%20factors%20associated%20with%20Clonorchis%20sinensis%20infections%20in%20rural%20communities%20in%20northern%20Vietnam&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Nguyen,%20Thao%20T.%20B.&rft.date=2020-08-01&rft.volume=14&rft.issue=8&rft.spage=e0008483&rft.pages=e0008483-&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0008483&rft_dat=%3Cgale_plos_%3EA634244015%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2443589280&rft_id=info:pmid/32745095&rft_galeid=A634244015&rft_doaj_id=oai_doaj_org_article_266f5930e32f48a3b92e784642e324c4&rfr_iscdi=true |