Age-related slowing down in the motor initiation in elderly adults
Age-related changes in the human brain functioning crucially affect the motor system, causing increased reaction time, low ability to control and execute movements, difficulties in learning new motor skills. The lifestyle and lowered daily activity of elderly adults, along with the deficit of motor...
Gespeichert in:
| Veröffentlicht in: | PloS one 2020-09, Vol.15 (9), p.e0233942-e0233942 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0233942 |
|---|---|
| container_issue | 9 |
| container_start_page | e0233942 |
| container_title | PloS one |
| container_volume | 15 |
| creator | Frolov, Nikita S Pitsik, Elena N Maksimenko, Vladimir A Grubov, Vadim V Kiselev, Anton R Wang, Zhen Hramov, Alexander E |
| description | Age-related changes in the human brain functioning crucially affect the motor system, causing increased reaction time, low ability to control and execute movements, difficulties in learning new motor skills. The lifestyle and lowered daily activity of elderly adults, along with the deficit of motor and cognitive brain functions, might lead to the developed ambidexterity, i.e., the loss of dominant limb advances. Despite the broad knowledge about the changes in cortical activity directly related to the motor execution, less is known about age-related differences in the motor initiation phase. We hypothesize that the latter strongly influences the behavioral characteristics, such as reaction time, the accuracy of motor performance, etc. Here, we compare the neuronal processes underlying the motor initiation phase preceding fine motor task execution between elderly and young subjects. Based on the results of the whole-scalp sensor-level electroencephalography (EEG) analysis, we demonstrate that the age-related slowing down in the motor initiation before the dominant hand movements is accompanied by the increased theta activation within sensorimotor area and reconfiguration of the theta-band functional connectivity in elderly adults. |
| doi_str_mv | 10.1371/journal.pone.0233942 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2443447920</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A635642696</galeid><doaj_id>oai_doaj_org_article_036b0786ef5a4fb0ad5d42ba6b2765f5</doaj_id><sourcerecordid>A635642696</sourcerecordid><originalsourceid>FETCH-LOGICAL-c669t-a04d5a4642746be2eb47614577180ebaf90e3978d3e7f9d39211e4e3b6b7d6653</originalsourceid><addsrcrecordid>eNqNkk1r3DAQhk1padJt_0GhhkJJD97KkixZl8I29GMhEOjXVcjW2KtFa20kuUn-fbVZt8Qlh6KDpNEz72iGN8telmhZEl6-27rRD8ou926AJcKECIofZaelILhgGJHH984n2bMQtghVpGbsaXZCsCCcVfg0-7DqofBgVQSdB-uuzdDn2l0PuRnyuIF856Lz6WKiUdG4uzhYDd7e5kqPNobn2ZNO2QAvpn2R_fj08fv5l-Li8vP6fHVRtIyJWChEdaUoo5hT1gCGhnJW0orzskbQqE4gIILXmgDvhCYClyVQIA1ruGasIovs1VF3b12QU_tBYkoJpVykNhfZ-khop7Zy781O-VvplJF3Aed7qXw0rQWJCGsQrxl06U9dg5SuNMWNYg1Og-kO1d5P1cZmB7qFIXplZ6Lzl8FsZO9-SU4FJYwngbNJwLurEUKUOxNasFYN4Mbjv2suKlYm9PU_6MPdTVSvUgNm6Fyq2x5E5YqRKg2WCZao5QNUWhp2pk1e6UyKzxLezhISE-Em9moMQa6_ff1_9vLnnH1zj92AsnETnB0PJgpzkB7B1rsQPHR_h1wiebD6n2nIg9XlZHXyG1qo7bo</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2443447920</pqid></control><display><type>article</type><title>Age-related slowing down in the motor initiation in elderly adults</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Frolov, Nikita S ; Pitsik, Elena N ; Maksimenko, Vladimir A ; Grubov, Vadim V ; Kiselev, Anton R ; Wang, Zhen ; Hramov, Alexander E</creator><creatorcontrib>Frolov, Nikita S ; Pitsik, Elena N ; Maksimenko, Vladimir A ; Grubov, Vadim V ; Kiselev, Anton R ; Wang, Zhen ; Hramov, Alexander E</creatorcontrib><description>Age-related changes in the human brain functioning crucially affect the motor system, causing increased reaction time, low ability to control and execute movements, difficulties in learning new motor skills. The lifestyle and lowered daily activity of elderly adults, along with the deficit of motor and cognitive brain functions, might lead to the developed ambidexterity, i.e., the loss of dominant limb advances. Despite the broad knowledge about the changes in cortical activity directly related to the motor execution, less is known about age-related differences in the motor initiation phase. We hypothesize that the latter strongly influences the behavioral characteristics, such as reaction time, the accuracy of motor performance, etc. Here, we compare the neuronal processes underlying the motor initiation phase preceding fine motor task execution between elderly and young subjects. Based on the results of the whole-scalp sensor-level electroencephalography (EEG) analysis, we demonstrate that the age-related slowing down in the motor initiation before the dominant hand movements is accompanied by the increased theta activation within sensorimotor area and reconfiguration of the theta-band functional connectivity in elderly adults.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0233942</identifier><identifier>PMID: 32937652</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Adults ; Age ; Aging ; Biology and Life Sciences ; Brain ; Cognitive ability ; EEG ; Electroencephalography ; Experiments ; Laboratories ; Medical research ; Medicine and Health Sciences ; Motor cortex ; Motor skill ; Motor skill learning ; Motor task performance ; Neural circuitry ; Neural networks ; Neurosciences ; Old age cognition ; Older people ; People and Places ; Physical Sciences ; Physiological aspects ; Psychological aspects ; Psychomotor performance ; Reaction time ; Reaction time task ; Reconfiguration ; Research and Analysis Methods ; Sensorimotor system ; Social Sciences ; Stability ; Young adults</subject><ispartof>PloS one, 2020-09, Vol.15 (9), p.e0233942-e0233942</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Frolov et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Frolov et al 2020 Frolov et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-a04d5a4642746be2eb47614577180ebaf90e3978d3e7f9d39211e4e3b6b7d6653</citedby><cites>FETCH-LOGICAL-c669t-a04d5a4642746be2eb47614577180ebaf90e3978d3e7f9d39211e4e3b6b7d6653</cites><orcidid>0000-0003-1850-2394 ; 0000-0002-2788-1907</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494367/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494367/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids></links><search><creatorcontrib>Frolov, Nikita S</creatorcontrib><creatorcontrib>Pitsik, Elena N</creatorcontrib><creatorcontrib>Maksimenko, Vladimir A</creatorcontrib><creatorcontrib>Grubov, Vadim V</creatorcontrib><creatorcontrib>Kiselev, Anton R</creatorcontrib><creatorcontrib>Wang, Zhen</creatorcontrib><creatorcontrib>Hramov, Alexander E</creatorcontrib><title>Age-related slowing down in the motor initiation in elderly adults</title><title>PloS one</title><description>Age-related changes in the human brain functioning crucially affect the motor system, causing increased reaction time, low ability to control and execute movements, difficulties in learning new motor skills. The lifestyle and lowered daily activity of elderly adults, along with the deficit of motor and cognitive brain functions, might lead to the developed ambidexterity, i.e., the loss of dominant limb advances. Despite the broad knowledge about the changes in cortical activity directly related to the motor execution, less is known about age-related differences in the motor initiation phase. We hypothesize that the latter strongly influences the behavioral characteristics, such as reaction time, the accuracy of motor performance, etc. Here, we compare the neuronal processes underlying the motor initiation phase preceding fine motor task execution between elderly and young subjects. Based on the results of the whole-scalp sensor-level electroencephalography (EEG) analysis, we demonstrate that the age-related slowing down in the motor initiation before the dominant hand movements is accompanied by the increased theta activation within sensorimotor area and reconfiguration of the theta-band functional connectivity in elderly adults.</description><subject>Adults</subject><subject>Age</subject><subject>Aging</subject><subject>Biology and Life Sciences</subject><subject>Brain</subject><subject>Cognitive ability</subject><subject>EEG</subject><subject>Electroencephalography</subject><subject>Experiments</subject><subject>Laboratories</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Motor cortex</subject><subject>Motor skill</subject><subject>Motor skill learning</subject><subject>Motor task performance</subject><subject>Neural circuitry</subject><subject>Neural networks</subject><subject>Neurosciences</subject><subject>Old age cognition</subject><subject>Older people</subject><subject>People and Places</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Psychological aspects</subject><subject>Psychomotor performance</subject><subject>Reaction time</subject><subject>Reaction time task</subject><subject>Reconfiguration</subject><subject>Research and Analysis Methods</subject><subject>Sensorimotor system</subject><subject>Social Sciences</subject><subject>Stability</subject><subject>Young adults</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkk1r3DAQhk1padJt_0GhhkJJD97KkixZl8I29GMhEOjXVcjW2KtFa20kuUn-fbVZt8Qlh6KDpNEz72iGN8telmhZEl6-27rRD8ou926AJcKECIofZaelILhgGJHH984n2bMQtghVpGbsaXZCsCCcVfg0-7DqofBgVQSdB-uuzdDn2l0PuRnyuIF856Lz6WKiUdG4uzhYDd7e5kqPNobn2ZNO2QAvpn2R_fj08fv5l-Li8vP6fHVRtIyJWChEdaUoo5hT1gCGhnJW0orzskbQqE4gIILXmgDvhCYClyVQIA1ruGasIovs1VF3b12QU_tBYkoJpVykNhfZ-khop7Zy781O-VvplJF3Aed7qXw0rQWJCGsQrxl06U9dg5SuNMWNYg1Og-kO1d5P1cZmB7qFIXplZ6Lzl8FsZO9-SU4FJYwngbNJwLurEUKUOxNasFYN4Mbjv2suKlYm9PU_6MPdTVSvUgNm6Fyq2x5E5YqRKg2WCZao5QNUWhp2pk1e6UyKzxLezhISE-Em9moMQa6_ff1_9vLnnH1zj92AsnETnB0PJgpzkB7B1rsQPHR_h1wiebD6n2nIg9XlZHXyG1qo7bo</recordid><startdate>20200916</startdate><enddate>20200916</enddate><creator>Frolov, Nikita S</creator><creator>Pitsik, Elena N</creator><creator>Maksimenko, Vladimir A</creator><creator>Grubov, Vadim V</creator><creator>Kiselev, Anton R</creator><creator>Wang, Zhen</creator><creator>Hramov, Alexander E</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1850-2394</orcidid><orcidid>https://orcid.org/0000-0002-2788-1907</orcidid></search><sort><creationdate>20200916</creationdate><title>Age-related slowing down in the motor initiation in elderly adults</title><author>Frolov, Nikita S ; Pitsik, Elena N ; Maksimenko, Vladimir A ; Grubov, Vadim V ; Kiselev, Anton R ; Wang, Zhen ; Hramov, Alexander E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-a04d5a4642746be2eb47614577180ebaf90e3978d3e7f9d39211e4e3b6b7d6653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adults</topic><topic>Age</topic><topic>Aging</topic><topic>Biology and Life Sciences</topic><topic>Brain</topic><topic>Cognitive ability</topic><topic>EEG</topic><topic>Electroencephalography</topic><topic>Experiments</topic><topic>Laboratories</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Motor cortex</topic><topic>Motor skill</topic><topic>Motor skill learning</topic><topic>Motor task performance</topic><topic>Neural circuitry</topic><topic>Neural networks</topic><topic>Neurosciences</topic><topic>Old age cognition</topic><topic>Older people</topic><topic>People and Places</topic><topic>Physical Sciences</topic><topic>Physiological aspects</topic><topic>Psychological aspects</topic><topic>Psychomotor performance</topic><topic>Reaction time</topic><topic>Reaction time task</topic><topic>Reconfiguration</topic><topic>Research and Analysis Methods</topic><topic>Sensorimotor system</topic><topic>Social Sciences</topic><topic>Stability</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frolov, Nikita S</creatorcontrib><creatorcontrib>Pitsik, Elena N</creatorcontrib><creatorcontrib>Maksimenko, Vladimir A</creatorcontrib><creatorcontrib>Grubov, Vadim V</creatorcontrib><creatorcontrib>Kiselev, Anton R</creatorcontrib><creatorcontrib>Wang, Zhen</creatorcontrib><creatorcontrib>Hramov, Alexander E</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frolov, Nikita S</au><au>Pitsik, Elena N</au><au>Maksimenko, Vladimir A</au><au>Grubov, Vadim V</au><au>Kiselev, Anton R</au><au>Wang, Zhen</au><au>Hramov, Alexander E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related slowing down in the motor initiation in elderly adults</atitle><jtitle>PloS one</jtitle><date>2020-09-16</date><risdate>2020</risdate><volume>15</volume><issue>9</issue><spage>e0233942</spage><epage>e0233942</epage><pages>e0233942-e0233942</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Age-related changes in the human brain functioning crucially affect the motor system, causing increased reaction time, low ability to control and execute movements, difficulties in learning new motor skills. The lifestyle and lowered daily activity of elderly adults, along with the deficit of motor and cognitive brain functions, might lead to the developed ambidexterity, i.e., the loss of dominant limb advances. Despite the broad knowledge about the changes in cortical activity directly related to the motor execution, less is known about age-related differences in the motor initiation phase. We hypothesize that the latter strongly influences the behavioral characteristics, such as reaction time, the accuracy of motor performance, etc. Here, we compare the neuronal processes underlying the motor initiation phase preceding fine motor task execution between elderly and young subjects. Based on the results of the whole-scalp sensor-level electroencephalography (EEG) analysis, we demonstrate that the age-related slowing down in the motor initiation before the dominant hand movements is accompanied by the increased theta activation within sensorimotor area and reconfiguration of the theta-band functional connectivity in elderly adults.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32937652</pmid><doi>10.1371/journal.pone.0233942</doi><tpages>e0233942</tpages><orcidid>https://orcid.org/0000-0003-1850-2394</orcidid><orcidid>https://orcid.org/0000-0002-2788-1907</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-09, Vol.15 (9), p.e0233942-e0233942 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2443447920 |
| source | Public Library of Science (PLoS) Journals Open Access; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adults Age Aging Biology and Life Sciences Brain Cognitive ability EEG Electroencephalography Experiments Laboratories Medical research Medicine and Health Sciences Motor cortex Motor skill Motor skill learning Motor task performance Neural circuitry Neural networks Neurosciences Old age cognition Older people People and Places Physical Sciences Physiological aspects Psychological aspects Psychomotor performance Reaction time Reaction time task Reconfiguration Research and Analysis Methods Sensorimotor system Social Sciences Stability Young adults |
| title | Age-related slowing down in the motor initiation in elderly adults |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T22%3A41%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Age-related%20slowing%20down%20in%20the%20motor%20initiation%20in%20elderly%20adults&rft.jtitle=PloS%20one&rft.au=Frolov,%20Nikita%20S&rft.date=2020-09-16&rft.volume=15&rft.issue=9&rft.spage=e0233942&rft.epage=e0233942&rft.pages=e0233942-e0233942&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0233942&rft_dat=%3Cgale_plos_%3EA635642696%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2443447920&rft_id=info:pmid/32937652&rft_galeid=A635642696&rft_doaj_id=oai_doaj_org_article_036b0786ef5a4fb0ad5d42ba6b2765f5&rfr_iscdi=true |