Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality
Allogeneic-HCT (allo-HCT), while potentially curative, can result in significant complications including graft versus host disease (GVHD). Prior studies suggest that metabolic syndrome may be one risk factor for GVHD. We hypothesized that hepatic steatosis on pre-HCT computed tomography (CT) scans m...
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| creator | Maung, Ko Ramalingam, Sendhilnathan Chaudhry, Mohammad Ren, Yi Jung, Sin-Ho Romero, Kristi Corbet, Kelly Chao, Nelson J Choi, Taewoong Diehl, Anna Mae Diehl, Louis Gasparetto, Cristina Horwitz, Mitchell Long, Gwynn Douglas Lopez, Richard D Rizzieri, David A Sarantopoulos, Stefanie Sullivan, Keith M Bashir, Mustafa R Sung, Anthony D |
| description | Allogeneic-HCT (allo-HCT), while potentially curative, can result in significant complications including graft versus host disease (GVHD). Prior studies suggest that metabolic syndrome may be one risk factor for GVHD. We hypothesized that hepatic steatosis on pre-HCT computed tomography (CT) scans may be a marker for development of GVHD and poor outcomes in allo-HCT. In this retrospective study, we reviewed the pre-HCT CT scans and transplant outcome data of patients who underwent allo-HCT at Duke University Medical Center from 2009 to 2017. The presence of steatosis was confirmed using CT attenuation measurements. We then assessed the association between pre-HCT hepatic steatosis and HCT-related outcomes including GVHD. 80 patients who had pre-HCT CT scans were included in the study. Pre-transplant hepatic steatosis was associated with the development of chronic GVHD (OR 4.2, p = 0.02), but was not associated with acute GVHD (OR 1.3, p = 0.7), non-relapse mortality (p = 0.81) or overall survival (p = 0.74). Based on this single center retrospective study, pre-transplant hepatic steatosis is associated with development of chronic GVHD. Further, prospective study with other imaging modalities including non-contrasted CT scans is needed to determine if this association is reproducible. |
| doi_str_mv | 10.1371/journal.pone.0238824 |
| format | Article |
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Prior studies suggest that metabolic syndrome may be one risk factor for GVHD. We hypothesized that hepatic steatosis on pre-HCT computed tomography (CT) scans may be a marker for development of GVHD and poor outcomes in allo-HCT. In this retrospective study, we reviewed the pre-HCT CT scans and transplant outcome data of patients who underwent allo-HCT at Duke University Medical Center from 2009 to 2017. The presence of steatosis was confirmed using CT attenuation measurements. We then assessed the association between pre-HCT hepatic steatosis and HCT-related outcomes including GVHD. 80 patients who had pre-HCT CT scans were included in the study. Pre-transplant hepatic steatosis was associated with the development of chronic GVHD (OR 4.2, p = 0.02), but was not associated with acute GVHD (OR 1.3, p = 0.7), non-relapse mortality (p = 0.81) or overall survival (p = 0.74). Based on this single center retrospective study, pre-transplant hepatic steatosis is associated with development of chronic GVHD. Further, prospective study with other imaging modalities including non-contrasted CT scans is needed to determine if this association is reproducible.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0238824</identifier><identifier>PMID: 32915853</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Abdomen ; Attenuation ; Biology and Life Sciences ; Cancer ; Complications ; Complications and side effects ; Computed tomography ; Cytokines ; Fatty liver ; Graft versus host disease ; Graft vs. host disease ; Graft-versus-host reaction ; Health care facilities ; Laboratories ; Liver diseases ; Liver transplantation ; Liver transplants ; Medicine ; Medicine and Health Sciences ; Metabolic disorders ; Metabolic syndrome ; Microbiota ; Mortality ; Musculoskeletal system ; Obesity ; Patients ; Research and Analysis Methods ; Risk analysis ; Risk factors ; Spleen ; Steatosis ; Stem cells ; Transplants & implants</subject><ispartof>PloS one, 2020-09, Vol.15 (9), p.e0238824-e0238824</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Maung et al. 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Prior studies suggest that metabolic syndrome may be one risk factor for GVHD. We hypothesized that hepatic steatosis on pre-HCT computed tomography (CT) scans may be a marker for development of GVHD and poor outcomes in allo-HCT. In this retrospective study, we reviewed the pre-HCT CT scans and transplant outcome data of patients who underwent allo-HCT at Duke University Medical Center from 2009 to 2017. The presence of steatosis was confirmed using CT attenuation measurements. We then assessed the association between pre-HCT hepatic steatosis and HCT-related outcomes including GVHD. 80 patients who had pre-HCT CT scans were included in the study. Pre-transplant hepatic steatosis was associated with the development of chronic GVHD (OR 4.2, p = 0.02), but was not associated with acute GVHD (OR 1.3, p = 0.7), non-relapse mortality (p = 0.81) or overall survival (p = 0.74). Based on this single center retrospective study, pre-transplant hepatic steatosis is associated with development of chronic GVHD. Further, prospective study with other imaging modalities including non-contrasted CT scans is needed to determine if this association is reproducible.</description><subject>Abdomen</subject><subject>Attenuation</subject><subject>Biology and Life Sciences</subject><subject>Cancer</subject><subject>Complications</subject><subject>Complications and side effects</subject><subject>Computed tomography</subject><subject>Cytokines</subject><subject>Fatty liver</subject><subject>Graft versus host disease</subject><subject>Graft vs. host disease</subject><subject>Graft-versus-host reaction</subject><subject>Health care facilities</subject><subject>Laboratories</subject><subject>Liver diseases</subject><subject>Liver transplantation</subject><subject>Liver transplants</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metabolic disorders</subject><subject>Metabolic 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associated with chronic graft-vs-host disease but not mortality</atitle><jtitle>PloS one</jtitle><date>2020-09-11</date><risdate>2020</risdate><volume>15</volume><issue>9</issue><spage>e0238824</spage><epage>e0238824</epage><pages>e0238824-e0238824</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Allogeneic-HCT (allo-HCT), while potentially curative, can result in significant complications including graft versus host disease (GVHD). Prior studies suggest that metabolic syndrome may be one risk factor for GVHD. We hypothesized that hepatic steatosis on pre-HCT computed tomography (CT) scans may be a marker for development of GVHD and poor outcomes in allo-HCT. In this retrospective study, we reviewed the pre-HCT CT scans and transplant outcome data of patients who underwent allo-HCT at Duke University Medical Center from 2009 to 2017. The presence of steatosis was confirmed using CT attenuation measurements. We then assessed the association between pre-HCT hepatic steatosis and HCT-related outcomes including GVHD. 80 patients who had pre-HCT CT scans were included in the study. Pre-transplant hepatic steatosis was associated with the development of chronic GVHD (OR 4.2, p = 0.02), but was not associated with acute GVHD (OR 1.3, p = 0.7), non-relapse mortality (p = 0.81) or overall survival (p = 0.74). Based on this single center retrospective study, pre-transplant hepatic steatosis is associated with development of chronic GVHD. Further, prospective study with other imaging modalities including non-contrasted CT scans is needed to determine if this association is reproducible.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32915853</pmid><doi>10.1371/journal.pone.0238824</doi><orcidid>https://orcid.org/0000-0003-0640-6282</orcidid><orcidid>https://orcid.org/0000-0003-3776-2407</orcidid><orcidid>https://orcid.org/0000-0003-3765-641X</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-09, Vol.15 (9), p.e0238824-e0238824 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Abdomen Attenuation Biology and Life Sciences Cancer Complications Complications and side effects Computed tomography Cytokines Fatty liver Graft versus host disease Graft vs. host disease Graft-versus-host reaction Health care facilities Laboratories Liver diseases Liver transplantation Liver transplants Medicine Medicine and Health Sciences Metabolic disorders Metabolic syndrome Microbiota Mortality Musculoskeletal system Obesity Patients Research and Analysis Methods Risk analysis Risk factors Spleen Steatosis Stem cells Transplants & implants |
| title | Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T00%3A19%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pre-transplant%20hepatic%20steatosis%20(fatty%20liver)%20is%20associated%20with%20chronic%20graft-vs-host%20disease%20but%20not%20mortality&rft.jtitle=PloS%20one&rft.au=Maung,%20Ko&rft.date=2020-09-11&rft.volume=15&rft.issue=9&rft.spage=e0238824&rft.epage=e0238824&rft.pages=e0238824-e0238824&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0238824&rft_dat=%3Cgale_plos_%3EA635164076%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2441872324&rft_id=info:pmid/32915853&rft_galeid=A635164076&rft_doaj_id=oai_doaj_org_article_c1d9528417af4ac88e3b02f0974c2a02&rfr_iscdi=true |