Protective effects of stem cells from human exfoliated deciduous teeth derived conditioned medium on osteoarthritic chondrocytes

Treatment of osteoarthritis (OA) is still a major clinical challenge due to the limited inherent healing capacity of cartilage. Recent studies utilising stem cells suggest that the therapeutic benefits of these cells are mediated through the paracrine mechanism of bioactive molecules. The present st...

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Veröffentlicht in:	PloS one 2020-09, Vol.15 (9), p.e0238449-e0238449
Hauptverfasser:	Muhammad, Suleiman Alhaji, Nordin, Norshariza, Hussin, Paisal, Mehat, Muhammad Zulfadli, Abu Kasim, Noor Hayaty, Fakurazi, Sharida, Papaccio, Gianpaolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggrecan Biological activity Biology and Life Sciences Biomedical materials Care and treatment Cartilage Cartilage cells Cartilage diseases Cell surface Chondrocytes Collagen Collagenase 3 Deciduous teeth Dentistry Extracellular matrix Genotype & phenotype Hematopoietic stem cells IL-1β Inflammation Interleukins Markers Matrix metalloproteinase Matrix metalloproteinases Medicine and Health Sciences Mesenchymal stem cells Mesenchyme Metalloproteinase NF-κB protein Oct-4 protein Osteoarthritis Paracrine signalling Physiological aspects Pluripotency Proteins Serum-free medium Stem cell transplantation Stem cells
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