Influence of beta-cluster haplotypes, alpha-gene status and UGTA1 polymorphism on clinical and hematological data in sickle-cell disease children from French Guiana

Objectives This cross-sectional study aimed to investigate the influence of haplotypes, alpha-gene status and UGTA1 polymorphism on the severity of sickle cell disease in children. Methods This cross-sectional study was conducted between 2012 and 2014 at the Cayenne Hospital, in French Guiana. Acute...

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Veröffentlicht in:	PloS one 2020-09, Vol.15 (9), p.e0238691-e0238691
Hauptverfasser:	Elenga, Narcisse, Cuadro-Alvarez, Emma, Martin, Elise, Njuieyon, Falucar, Defo, Antoine, Maniassom, Chimène
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Children Complications Gallstones Gene deletion Gene polymorphism Haplotypes Hematology Hemoglobin Hospitals Medical records Medical screening Medicine and Health Sciences Multivariate analysis Mutation Patients Pediatrics People and Places Phenotypes Polymorphism Population Sickle cell disease Thalassemia Ultrasound
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