A genetic analysis of a Spanish population with early onset Parkinson's disease

Both recessive and dominant genetic forms of Parkinson's disease have been described. The aim of this study was to assess the contribution of several genes to the pathophysiology of early onset Parkinson's disease in a cohort from central Spain. We analyzed a cohort of 117 unrelated patien...

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Veröffentlicht in:	PloS one 2020-09, Vol.15 (9), p.e0238098-e0238098
Hauptverfasser:	Cristina, Tejera-Parrado, Pablo, Mir, Teresa, Periñán María, Lydia, Vela-Desojo, Irene, Abreu-Rodríguez, Araceli, Alonso-Cánovas, Inmaculada, Bernal-Bernal, Marta, Bonilla-Toribio, Dolores, Buiza-Rueda, José, Catalán-Alonso María, Rocío, García-Ramos, José, García-Ruiz Pedro, Ismael, Huertas-Fernández, Silvia, Jesús, Labrador, Miguel A-Espinosa, Lydia, López-Manzanares, Carlos, Martínez-Castrillo Juan, Posada, Ignacio J, Ana, Rojo-Sebastián, Cristina, Ruiz-Huete, Javier, Del Val, Gómez-Garre, Pilar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Analysis Biology and Life Sciences Cohort Studies Deoxyribonucleic acid Development and progression DNA Female Genes Genetic analysis Genetic aspects Genetic screening Genetic Testing Genetic Variation Genomes Health risks High-Throughput Nucleotide Sequencing Humans LRRK2 protein Male Medicine and Health Sciences Middle Aged Movement disorders Mutation Neurodegenerative diseases Next-generation sequencing PARK7 protein Parkinson disease Parkinson Disease - epidemiology Parkinson Disease - genetics Parkinson's disease People and places Proteins PTEN-induced putative kinase Research and analysis methods Spain - epidemiology
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