Restricting extracellular Ca2+ on gefitinib-resistant non-small cell lung cancer cells reverses altered epidermal growth factor-mediated Ca2+ response, which consequently enhances gefitinib sensitivity

Non-small cell lung cancer (NSCLC), one of the leading causes of cancer-related death, has a low 5-year survival rate owing to the inevitable acquired resistance toward antitumor drugs, platinum-based chemotherapy, and targeted therapy. Epidermal growth factor (EGF)-EGF receptor (EGFR) signaling act...

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Veröffentlicht in:	PloS one 2020-08, Vol.15 (8), p.e0238155-e0238155
Hauptverfasser:	Kim, Mi Seong, Kim, So Hui, Yang, Sei Hoon, Kim, Min Seuk
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Apoptosis Bcl-2 protein Biology and Life Sciences Calcium (extracellular) Calcium (intracellular) Calcium (reticular) Calcium influx Calcium ions Calcium signalling Cell proliferation Chemotherapy Cytotoxicity Drug resistance Endoplasmic reticulum Epidermal growth factor Epidermal growth factor receptors Gefitinib Growth factors Inhibitor drugs Inositol trisphosphate Intracellular Kinases Lung cancer Lung diseases Lymphocytes Medicine and Health Sciences Mutation NF-AT1 protein Non-small cell lung carcinoma Oscillations Phospholipase Phospholipase C Platinum Ribose Sensitivity enhancement Signaling Survival Targeted cancer therapy Toxicity
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