Protein-conformational diseases in childhood: Naturally-occurring hIAPP amyloid-oligomers and early β-cell damage in obesity and diabetes

Background and aims This is the first time that obesity and diabetes mellitus (DM) as protein conformational diseases (PCD) are reported in children and they are typically diagnosed too late, when β-cell damage is evident. Here we wanted to investigate the level of naturally-ocurring or real (not sy...

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Veröffentlicht in:	PloS one 2020-08, Vol.15 (8), p.e0237667
Hauptverfasser:	Altamirano-Bustamante, Nelly F., Garrido-Magaña, Eulalia, Morán, Eugenia, Calderón, Aurora, Pasten-Hidalgo, Karina, Castillo-Rodríguez, Rosa Angélica, Rojas, Gerardo, Lara-Martínez, Reyna, Leyva-García, Edgar, Larralde-Laborde, Mateo, Domíguez, Guadalupe, Murata, Chiharu, Margarita-Vazquez, Yolanda, Payro, Rafael, Barbosa, Manuel, Valderrama, Alejandro, Montesinos, Hortencia, Domínguez-Camacho, Alejandra, García-Olmos, Víctor H., Ferrer, Regina, Medina-Bravo, Patricia G., Santoscoy, Fernanda, Revilla-Monsalve, Cristina, Jiménez-García, Luis Felipe, Morán, Julio, Villalobos-Alva, Jalil, Villalobos, Mario Javier, Calzada-León, Raúl, Altamirano, Perla, Altamirano-Bustamante, Myriam M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylin Amyloid Antibodies Beta cells Biology and Life Sciences Biomarkers Biomedical materials Cell viability Childhood Children Clinical decision making Complications Cytotoxicity Damage Decision making Diabetes Diabetes mellitus Electron microscopy Health risks Hospitals Medicine Medicine and Health Sciences Methods Morphology Obesity Oligomers Patients Pediatrics Physical Sciences Polyclonal antibodies Polypeptides Proteins Research and Analysis Methods Transmission electron microscopy
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