The relation of 25-hydroxy vitamin D concentrations to liver histopathology, seasonality and baseline characteristics in chronic hepatitis C virus genotype 2 or 3 infection
The hydroxylation to 25-hydroxy vitamin D (25(OH)D) occurs in the liver and the impact of liver disease on vitamin D is unclear. This study evaluated the relationship between vitamin D concentrations and hepatic histopathology, seasonality and patient characteristics in well-characterized patients h...
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| creator | Waldenstrom, Jesper Nystrom, Kristina Nilsson, Staffan Norkrans, Gunnar Ydreborg, Magdalena Langeland, Nina Morch, Kristine Westin, Johan Lagging, Martin |
| description | The hydroxylation to 25-hydroxy vitamin D (25(OH)D) occurs in the liver and the impact of liver disease on vitamin D is unclear. This study evaluated the relationship between vitamin D concentrations and hepatic histopathology, seasonality and patient characteristics in well-characterized patients having undergone a liver biopsy. 25(OH)D was measured post-hoc in pre-treatment serum from 331 North European patients with chronic HCV genotype 2 or 3 infection (NORDynamIC study). Liver biopsies were scored for fibrosis and inflammation according to the Ishak protocol, and graded for steatosis. Non-invasive markers of hepatic fibrosis as well as baseline viral and host characteristics, including genetic polymorphisms rs2228570, rs7975232, and rs10877012 were also evaluated. Mean 25(OH)D concentration was 59 ±23 nmol/L, with 41% having values |
| doi_str_mv | 10.1371/journal.pone.0237840 |
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This study evaluated the relationship between vitamin D concentrations and hepatic histopathology, seasonality and patient characteristics in well-characterized patients having undergone a liver biopsy. 25(OH)D was measured post-hoc in pre-treatment serum from 331 North European patients with chronic HCV genotype 2 or 3 infection (NORDynamIC study). Liver biopsies were scored for fibrosis and inflammation according to the Ishak protocol, and graded for steatosis. Non-invasive markers of hepatic fibrosis as well as baseline viral and host characteristics, including genetic polymorphisms rs2228570, rs7975232, and rs10877012 were also evaluated. Mean 25(OH)D concentration was 59 ±23 nmol/L, with 41% having values <50 nmol/L and 6% were <30 nmol/L. 25(OH)D correlated with fibrosis (r = -0.10, p [less than or equal to]0.05) in univariate but not in multivariate analyses. No association was observed between 25(OH)D and hepatic inflammation, but with steatosis in HCV genotype 2 infected patients. None of the genetic polymorphisms impacted on 25(OH)D levels or fibrosis. 25(OH)D levels were significantly inversely correlated to BMI (r = -0.19, p = 0.001), and was also associated with season and non-Caucasian ethnicity. Fibrosis was not independently associated with 25(OH)D concentration and no association was seen with hepatic inflammation, but HCV genotype 2 infected patients with moderate-to-severe steatosis had lower 25(OH)D levels compared to those without steatosis. A high percentage had potential risk of 25(OH)D deficiency, and BMI, seasonality and ethnicity were independently associated with 25(OH)D as previously reported.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0237840</identifier><identifier>PMID: 32822420</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>association ; Biology and Life Sciences ; Biopsy ; body-mass index ; Calciferol ; Chronic infection ; d deficiency ; Diagnosis ; disease ; Evaluation ; fat ; Fatty liver ; Fibrosis ; Gene polymorphism ; Genotype & phenotype ; Haplotypes ; Health aspects ; Hepatitis ; Hepatitis C ; Histopathology ; Hospitals ; Hydroxylation ; Infections ; Infectious diseases ; Infectious Medicine ; Infektionsmedicin ; Inflammation ; Interferon ; latitude ; Liver ; Liver cirrhosis ; Liver diseases ; Medicine and health sciences ; Metabolism ; Mineralization ; Minority & ethnic groups ; Physical sciences ; Population ; rather ; Science & Technology - Other Topics ; Seasonal variations ; Steatosis ; Viruses ; Vitamin D ; Vitamin deficiency</subject><ispartof>PloS one, 2020-08, Vol.15 (8), p.e0237840-e0237840</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Waldenström et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Waldenström et al 2020 Waldenström et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c783t-f4445262f95dc139052d43f67e704260449509ed1e496d41352119093850c73f3</citedby><cites>FETCH-LOGICAL-c783t-f4445262f95dc139052d43f67e704260449509ed1e496d41352119093850c73f3</cites><orcidid>0000-0002-7995-3626 ; 0000-0003-2234-0076</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442235/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442235/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,552,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://gup.ub.gu.se/publication/296730$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://research.chalmers.se/publication/518992$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><contributor>Villar, Livia Melo</contributor><creatorcontrib>Waldenstrom, Jesper</creatorcontrib><creatorcontrib>Nystrom, Kristina</creatorcontrib><creatorcontrib>Nilsson, Staffan</creatorcontrib><creatorcontrib>Norkrans, Gunnar</creatorcontrib><creatorcontrib>Ydreborg, Magdalena</creatorcontrib><creatorcontrib>Langeland, Nina</creatorcontrib><creatorcontrib>Morch, Kristine</creatorcontrib><creatorcontrib>Westin, Johan</creatorcontrib><creatorcontrib>Lagging, Martin</creatorcontrib><title>The relation of 25-hydroxy vitamin D concentrations to liver histopathology, seasonality and baseline characteristics in chronic hepatitis C virus genotype 2 or 3 infection</title><title>PloS one</title><description>The hydroxylation to 25-hydroxy vitamin D (25(OH)D) occurs in the liver and the impact of liver disease on vitamin D is unclear. This study evaluated the relationship between vitamin D concentrations and hepatic histopathology, seasonality and patient characteristics in well-characterized patients having undergone a liver biopsy. 25(OH)D was measured post-hoc in pre-treatment serum from 331 North European patients with chronic HCV genotype 2 or 3 infection (NORDynamIC study). Liver biopsies were scored for fibrosis and inflammation according to the Ishak protocol, and graded for steatosis. Non-invasive markers of hepatic fibrosis as well as baseline viral and host characteristics, including genetic polymorphisms rs2228570, rs7975232, and rs10877012 were also evaluated. Mean 25(OH)D concentration was 59 ±23 nmol/L, with 41% having values <50 nmol/L and 6% were <30 nmol/L. 25(OH)D correlated with fibrosis (r = -0.10, p [less than or equal to]0.05) in univariate but not in multivariate analyses. No association was observed between 25(OH)D and hepatic inflammation, but with steatosis in HCV genotype 2 infected patients. None of the genetic polymorphisms impacted on 25(OH)D levels or fibrosis. 25(OH)D levels were significantly inversely correlated to BMI (r = -0.19, p = 0.001), and was also associated with season and non-Caucasian ethnicity. Fibrosis was not independently associated with 25(OH)D concentration and no association was seen with hepatic inflammation, but HCV genotype 2 infected patients with moderate-to-severe steatosis had lower 25(OH)D levels compared to those without steatosis. A high percentage had potential risk of 25(OH)D deficiency, and BMI, seasonality and ethnicity were independently associated with 25(OH)D as previously reported.</description><subject>association</subject><subject>Biology and Life Sciences</subject><subject>Biopsy</subject><subject>body-mass index</subject><subject>Calciferol</subject><subject>Chronic infection</subject><subject>d deficiency</subject><subject>Diagnosis</subject><subject>disease</subject><subject>Evaluation</subject><subject>fat</subject><subject>Fatty liver</subject><subject>Fibrosis</subject><subject>Gene polymorphism</subject><subject>Genotype & phenotype</subject><subject>Haplotypes</subject><subject>Health aspects</subject><subject>Hepatitis</subject><subject>Hepatitis C</subject><subject>Histopathology</subject><subject>Hospitals</subject><subject>Hydroxylation</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Infectious Medicine</subject><subject>Infektionsmedicin</subject><subject>Inflammation</subject><subject>Interferon</subject><subject>latitude</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Medicine and health sciences</subject><subject>Metabolism</subject><subject>Mineralization</subject><subject>Minority & ethnic groups</subject><subject>Physical sciences</subject><subject>Population</subject><subject>rather</subject><subject>Science & Technology - Other Topics</subject><subject>Seasonal variations</subject><subject>Steatosis</subject><subject>Viruses</subject><subject>Vitamin D</subject><subject>Vitamin 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relation of 25-hydroxy vitamin D concentrations to liver histopathology, seasonality and baseline characteristics in chronic hepatitis C virus genotype 2 or 3 infection</title><author>Waldenstrom, Jesper ; Nystrom, Kristina ; Nilsson, Staffan ; Norkrans, Gunnar ; Ydreborg, Magdalena ; Langeland, Nina ; Morch, Kristine ; Westin, Johan ; Lagging, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c783t-f4445262f95dc139052d43f67e704260449509ed1e496d41352119093850c73f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>association</topic><topic>Biology and Life Sciences</topic><topic>Biopsy</topic><topic>body-mass index</topic><topic>Calciferol</topic><topic>Chronic infection</topic><topic>d deficiency</topic><topic>Diagnosis</topic><topic>disease</topic><topic>Evaluation</topic><topic>fat</topic><topic>Fatty liver</topic><topic>Fibrosis</topic><topic>Gene 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högskola full text</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Chalmers tekniska högskola</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Waldenstrom, Jesper</au><au>Nystrom, Kristina</au><au>Nilsson, Staffan</au><au>Norkrans, Gunnar</au><au>Ydreborg, Magdalena</au><au>Langeland, Nina</au><au>Morch, Kristine</au><au>Westin, Johan</au><au>Lagging, Martin</au><au>Villar, Livia Melo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relation of 25-hydroxy vitamin D concentrations to liver histopathology, seasonality and baseline characteristics in chronic hepatitis C virus genotype 2 or 3 infection</atitle><jtitle>PloS one</jtitle><date>2020-08-21</date><risdate>2020</risdate><volume>15</volume><issue>8</issue><spage>e0237840</spage><epage>e0237840</epage><pages>e0237840-e0237840</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The hydroxylation to 25-hydroxy vitamin D (25(OH)D) occurs in the liver and the impact of liver disease on vitamin D is unclear. This study evaluated the relationship between vitamin D concentrations and hepatic histopathology, seasonality and patient characteristics in well-characterized patients having undergone a liver biopsy. 25(OH)D was measured post-hoc in pre-treatment serum from 331 North European patients with chronic HCV genotype 2 or 3 infection (NORDynamIC study). Liver biopsies were scored for fibrosis and inflammation according to the Ishak protocol, and graded for steatosis. Non-invasive markers of hepatic fibrosis as well as baseline viral and host characteristics, including genetic polymorphisms rs2228570, rs7975232, and rs10877012 were also evaluated. Mean 25(OH)D concentration was 59 ±23 nmol/L, with 41% having values <50 nmol/L and 6% were <30 nmol/L. 25(OH)D correlated with fibrosis (r = -0.10, p [less than or equal to]0.05) in univariate but not in multivariate analyses. No association was observed between 25(OH)D and hepatic inflammation, but with steatosis in HCV genotype 2 infected patients. None of the genetic polymorphisms impacted on 25(OH)D levels or fibrosis. 25(OH)D levels were significantly inversely correlated to BMI (r = -0.19, p = 0.001), and was also associated with season and non-Caucasian ethnicity. Fibrosis was not independently associated with 25(OH)D concentration and no association was seen with hepatic inflammation, but HCV genotype 2 infected patients with moderate-to-severe steatosis had lower 25(OH)D levels compared to those without steatosis. A high percentage had potential risk of 25(OH)D deficiency, and BMI, seasonality and ethnicity were independently associated with 25(OH)D as previously reported.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32822420</pmid><doi>10.1371/journal.pone.0237840</doi><tpages>e0237840</tpages><orcidid>https://orcid.org/0000-0002-7995-3626</orcidid><orcidid>https://orcid.org/0000-0003-2234-0076</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_2436141589 |
| source | DOAJ Directory of Open Access Journals; SWEPUB Freely available online; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | association Biology and Life Sciences Biopsy body-mass index Calciferol Chronic infection d deficiency Diagnosis disease Evaluation fat Fatty liver Fibrosis Gene polymorphism Genotype & phenotype Haplotypes Health aspects Hepatitis Hepatitis C Histopathology Hospitals Hydroxylation Infections Infectious diseases Infectious Medicine Infektionsmedicin Inflammation Interferon latitude Liver Liver cirrhosis Liver diseases Medicine and health sciences Metabolism Mineralization Minority & ethnic groups Physical sciences Population rather Science & Technology - Other Topics Seasonal variations Steatosis Viruses Vitamin D Vitamin deficiency |
| title | The relation of 25-hydroxy vitamin D concentrations to liver histopathology, seasonality and baseline characteristics in chronic hepatitis C virus genotype 2 or 3 infection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T01%3A31%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20relation%20of%2025-hydroxy%20vitamin%20D%20concentrations%20to%20liver%20histopathology,%20seasonality%20and%20baseline%20characteristics%20in%20chronic%20hepatitis%20C%20virus%20genotype%202%20or%203%20infection&rft.jtitle=PloS%20one&rft.au=Waldenstrom,%20Jesper&rft.date=2020-08-21&rft.volume=15&rft.issue=8&rft.spage=e0237840&rft.epage=e0237840&rft.pages=e0237840-e0237840&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0237840&rft_dat=%3Cgale_plos_%3EA633157733%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2436141589&rft_id=info:pmid/32822420&rft_galeid=A633157733&rft_doaj_id=oai_doaj_org_article_10678af575184cf080c0b1c194922397&rfr_iscdi=true |