Antimalarial drug resistance molecular makers of Plasmodium falciparum isolates from Sudan during 2015-2017

Current malaria control and elimination strategies rely mainly on efficacious antimalarial drugs. However, drug resistance is a major threat facing malaria control programs. Determination of drug resistance molecular markers is useful in the monitoring and surveillance of malaria drug efficacy. This...

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Veröffentlicht in:	PloS one 2020-08, Vol.15 (8), p.e0235401-e0235401
Hauptverfasser:	Hussien, Maazza, Abdel Hamid, Muzamil Mahdi, Elamin, Elamin Abdelkarim, Hassan, Abdalla O, Elaagip, Arwa H, Salama, Abusofyan Hamattallah A, Abdelraheem, Mohammed H, Mohamed, Abdelrahim O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antimalarial agents Antimalarials - pharmacology Biology and Life Sciences Child Chloroquine Chloroquine - pharmacology Codons Control Control programs Deoxyribonucleic acid Dihydrofolate reductase DNA Drug efficacy Drug resistance Drug Resistance - genetics Drug therapy Entomology Erythrocytes Ethics Exonuclease Female Ferredoxin Gene frequency Genes Genetic aspects Genomes Genotypes Genotyping Haplotypes Humans Infections Malaria Malaria - epidemiology Malaria - parasitology Male Medical laboratories Medicine and Health Sciences Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Microbial drug resistance Mitochondria Mortality Multiplicity of infection Mutants Mutation Parasites Parasitology People and Places Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Plasmodium falciparum - pathogenicity Protozoan Proteins - genetics Protozoan Proteins - metabolism Pyrimethamine Pyrimethamine - pharmacology Single-nucleotide polymorphism Speciation Statistics Sudan Sulfadoxine Sulfadoxine - pharmacology Tetrahydrofolate Dehydrogenase - genetics Tetrahydrofolate Dehydrogenase - metabolism Vector-borne diseases Young Adult
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