Lipids, biomarkers, and subclinical atherosclerosis in treatment-naive HIV patients starting or not starting antiretroviral therapy: Comparison with a healthy control group in a 2-year prospective study
To assess the effect of HIV infection and combined antiretroviral therapy (c-ART) on various proatherogenic biomarkers and lipids and to investigate their relationship with subclinical atherosclerosis in a cohort of treatment-naive HIV-infected patients. We performed a prospective, comparative, mult...
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| creator | Di Yacovo, Silvana Saumoy, Maria Sanchez-Quesada, Jose Luis Navarro, Antonio Sviridov, Dmitri Javaloyas, Manuel Vila, Ramon Vernet, Anton Low, Hann Penafiel, Judith Garcia, Benito Ordonez-Llanos, Jordi Podzamczer, Daniel |
| description | To assess the effect of HIV infection and combined antiretroviral therapy (c-ART) on various proatherogenic biomarkers and lipids and to investigate their relationship with subclinical atherosclerosis in a cohort of treatment-naive HIV-infected patients. We performed a prospective, comparative, multicenter study of 2 groups of treatment-naive HIV-infected patients (group A, CD4>500 cells/[mu]L, not starting c-ART; and group B, CD4 |
| doi_str_mv | 10.1371/journal.pone.0237739 |
| format | Article |
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We performed a prospective, comparative, multicenter study of 2 groups of treatment-naive HIV-infected patients (group A, CD4>500 cells/[mu]L, not starting c-ART; and group B, CD4<500 cells/[mu]L, starting c-ART at baseline) and a healthy control group. Laboratory analyses and carotid ultrasound were performed at baseline and at months 12 and 24. The parameters measured were low-density lipoprotein (LDL) particle phenotype, lipoprotein-associated phospholipase A2 (Lp-PLA2), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), sCD14, sCD163, monocyte chemoattractant protein-1(MCP-1), and asymmetric dimethylarginine (ADMA). A linear mixed model based on patient clusters was used to assess differences in biomarkers between the study groups and over time. The study population comprised 62 HIV-infected patients (group A, n = 31; group B, n = 31) and 22 controls. Age was 37 (30-43) years, and 81% were men. At baseline, the HIV-infected patients had a worse LDL particle phenotype and higher plasma concentration of sCD14, sCD163, hs-CRP, and LDL-Lp-PLA2 than the controls. At month 12, there was an increase in total cholesterol (p = 0.002), HDL-c (p = 0.003), and Apo A-I (p = 0.049) and a decrease in sCD14 (p = <0.001) and sCD163 (p<0.001), although only in group B. LDL particle size increased in group B at month 24 (p = 0.038). No changes were observed in group A or in the healthy controls. Common carotid intima-media thickness increased in HIV-infected patients at month 24 (Group A p = 0.053; group B p = 0.048). Plasma levels of sCD14, sCD163, and hs-CRP correlated with lipid values. In treatment-naive HIV-infected patients, initiation of c-ART was associated with an improvement in LDL particle phenotype and inflammatory/immune biomarkers, reaching values similar to those of the controls. HIV infection was associated with progression of carotid intima-media thickness.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0237739</identifier><identifier>PMID: 32817629</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Antiretroviral agents ; Antiretroviral drugs ; Antiretroviral therapy ; Apolipoproteins ; Arteriosclerosis ; Atherosclerosis ; Biochemistry ; Biological markers ; Biology and Life Sciences ; Biomarkers ; Biomedical research ; Blood lipids ; C-reactive protein ; Cardiovascular disease ; Care and treatment ; CD4 antigen ; Cholesterol ; Coronary vessels ; Development and progression ; Diabetes ; Diagnosis ; Drug therapy ; Evaluation ; Genotype & phenotype ; Health aspects ; High density lipoprotein ; Highly active antiretroviral therapy ; HIV ; HIV patients ; Human immunodeficiency virus ; Infections ; Infectious diseases ; Inflammation ; Interleukin ; Interleukin 6 ; Laboratories ; Lipids ; Lipoproteins ; Low density lipoprotein ; Medicine and Health Sciences ; Metabolism ; Methods ; Molecular biology ; Monocyte chemoattractant protein ; Monocyte chemoattractant protein 1 ; Monocytes ; Patient outcomes ; Phenotypes ; Phospholipase ; Phospholipase A2 ; Plasma levels ; Population studies ; Proteins ; Studies ; Thickness ; Ultrasonic imaging ; Ultrasound</subject><ispartof>PloS one, 2020-08, Vol.15 (8), p.e0237739-e0237739</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Di Yacovo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Di Yacovo et al 2020 Di Yacovo et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-c7883f045df9ce673614ba1e0f5c25d1f506ee5f81aa48ef993386bf87817c333</citedby><cites>FETCH-LOGICAL-c669t-c7883f045df9ce673614ba1e0f5c25d1f506ee5f81aa48ef993386bf87817c333</cites><orcidid>0000-0002-0047-1991 ; 0000-0002-7028-1368</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446923/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446923/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23868,27926,27927,53793,53795</link.rule.ids></links><search><contributor>Eugenin, Eliseo A.</contributor><creatorcontrib>Di Yacovo, Silvana</creatorcontrib><creatorcontrib>Saumoy, Maria</creatorcontrib><creatorcontrib>Sanchez-Quesada, Jose Luis</creatorcontrib><creatorcontrib>Navarro, Antonio</creatorcontrib><creatorcontrib>Sviridov, Dmitri</creatorcontrib><creatorcontrib>Javaloyas, Manuel</creatorcontrib><creatorcontrib>Vila, Ramon</creatorcontrib><creatorcontrib>Vernet, Anton</creatorcontrib><creatorcontrib>Low, Hann</creatorcontrib><creatorcontrib>Penafiel, Judith</creatorcontrib><creatorcontrib>Garcia, Benito</creatorcontrib><creatorcontrib>Ordonez-Llanos, Jordi</creatorcontrib><creatorcontrib>Podzamczer, Daniel</creatorcontrib><title>Lipids, biomarkers, and subclinical atherosclerosis in treatment-naive HIV patients starting or not starting antiretroviral therapy: Comparison with a healthy control group in a 2-year prospective study</title><title>PloS one</title><description>To assess the effect of HIV infection and combined antiretroviral therapy (c-ART) on various proatherogenic biomarkers and lipids and to investigate their relationship with subclinical atherosclerosis in a cohort of treatment-naive HIV-infected patients. We performed a prospective, comparative, multicenter study of 2 groups of treatment-naive HIV-infected patients (group A, CD4>500 cells/[mu]L, not starting c-ART; and group B, CD4<500 cells/[mu]L, starting c-ART at baseline) and a healthy control group. Laboratory analyses and carotid ultrasound were performed at baseline and at months 12 and 24. The parameters measured were low-density lipoprotein (LDL) particle phenotype, lipoprotein-associated phospholipase A2 (Lp-PLA2), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), sCD14, sCD163, monocyte chemoattractant protein-1(MCP-1), and asymmetric dimethylarginine (ADMA). A linear mixed model based on patient clusters was used to assess differences in biomarkers between the study groups and over time. The study population comprised 62 HIV-infected patients (group A, n = 31; group B, n = 31) and 22 controls. Age was 37 (30-43) years, and 81% were men. At baseline, the HIV-infected patients had a worse LDL particle phenotype and higher plasma concentration of sCD14, sCD163, hs-CRP, and LDL-Lp-PLA2 than the controls. At month 12, there was an increase in total cholesterol (p = 0.002), HDL-c (p = 0.003), and Apo A-I (p = 0.049) and a decrease in sCD14 (p = <0.001) and sCD163 (p<0.001), although only in group B. LDL particle size increased in group B at month 24 (p = 0.038). No changes were observed in group A or in the healthy controls. Common carotid intima-media thickness increased in HIV-infected patients at month 24 (Group A p = 0.053; group B p = 0.048). Plasma levels of sCD14, sCD163, and hs-CRP correlated with lipid values. In treatment-naive HIV-infected patients, initiation of c-ART was associated with an improvement in LDL particle phenotype and inflammatory/immune biomarkers, reaching values similar to those of the controls. HIV infection was associated with progression of carotid intima-media thickness.</description><subject>Antiretroviral agents</subject><subject>Antiretroviral drugs</subject><subject>Antiretroviral therapy</subject><subject>Apolipoproteins</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Biochemistry</subject><subject>Biological markers</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomedical research</subject><subject>Blood lipids</subject><subject>C-reactive protein</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>CD4 antigen</subject><subject>Cholesterol</subject><subject>Coronary vessels</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Drug therapy</subject><subject>Evaluation</subject><subject>Genotype & phenotype</subject><subject>Health aspects</subject><subject>High density lipoprotein</subject><subject>Highly active antiretroviral therapy</subject><subject>HIV</subject><subject>HIV patients</subject><subject>Human immunodeficiency virus</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Interleukin</subject><subject>Interleukin 6</subject><subject>Laboratories</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Low density lipoprotein</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Methods</subject><subject>Molecular biology</subject><subject>Monocyte chemoattractant protein</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Monocytes</subject><subject>Patient outcomes</subject><subject>Phenotypes</subject><subject>Phospholipase</subject><subject>Phospholipase A2</subject><subject>Plasma levels</subject><subject>Population studies</subject><subject>Proteins</subject><subject>Studies</subject><subject>Thickness</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9-K1DAUxoso7rr6BoIBQRScMWnapPVCWAZ1BwYW_LO34TRNZjJ2km6Sjs4r-lSmO6PuyF5IoU1Of_lO8p2cLHtK8JRQTt6s3eAtdNPeWTXFOeWc1veyU1LTfMJyTO_fGp9kj0JYY1zSirGH2QnNK8JZXp9mPxemN214jRrjNuC_KZ_GYFsUhkZ2xhoJHYK4Ut4F2Y1vE5CxKHoFcaNsnFgwW4Uu5leoh2hSJKAQwUdjl8h5ZF38OwcbjVfRu63xSXeUhX73Fs3cpgdvgrPou4krBGiloIurHZLOJrxDS--GfkwMKJ_sFHjUp730SsYxe4hDu3ucPdDQBfXk8D3Lvn54_2V2MVlcfpzPzhcTyVgdJ5JXFdW4KFtdS8U4ZaRogCisS5mXLdElZkqVuiIARaV0XdPkWqMrnjyTlNKz7Nlet-9cEIcyBJEXtOQFw7RKxHxPtA7WovcmObsTDoy4CTi_FKMhyU-BicSaA9GkrIuGN3VeN8A4YbVsS8JY0np3yDY0G9XKZHCy7kj0-I81K7F0W8GLgtX5uN2XBwHvrgcVotiYIFXXgVVuuNk3KzDFtEjo83_Qu093oJaQDmCsdimvHEXFOaMUF1XFy0RN76DS06qNSVVV2qT40YJXRwvGyqsfcQlDCGL--dP_s5dXx-yLW-z-XgXXDdE4G47BYg_KdLOCV_qPyQSLseV-uyHGlhOHlqO_AHZiIXc</recordid><startdate>20200820</startdate><enddate>20200820</enddate><creator>Di 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Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di Yacovo, Silvana</au><au>Saumoy, Maria</au><au>Sanchez-Quesada, Jose Luis</au><au>Navarro, Antonio</au><au>Sviridov, Dmitri</au><au>Javaloyas, Manuel</au><au>Vila, Ramon</au><au>Vernet, Anton</au><au>Low, Hann</au><au>Penafiel, Judith</au><au>Garcia, Benito</au><au>Ordonez-Llanos, Jordi</au><au>Podzamczer, Daniel</au><au>Eugenin, Eliseo A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipids, biomarkers, and subclinical atherosclerosis in treatment-naive HIV patients starting or not starting antiretroviral therapy: Comparison with a healthy control group in a 2-year prospective study</atitle><jtitle>PloS one</jtitle><date>2020-08-20</date><risdate>2020</risdate><volume>15</volume><issue>8</issue><spage>e0237739</spage><epage>e0237739</epage><pages>e0237739-e0237739</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To assess the effect of HIV infection and combined antiretroviral therapy (c-ART) on various proatherogenic biomarkers and lipids and to investigate their relationship with subclinical atherosclerosis in a cohort of treatment-naive HIV-infected patients. We performed a prospective, comparative, multicenter study of 2 groups of treatment-naive HIV-infected patients (group A, CD4>500 cells/[mu]L, not starting c-ART; and group B, CD4<500 cells/[mu]L, starting c-ART at baseline) and a healthy control group. Laboratory analyses and carotid ultrasound were performed at baseline and at months 12 and 24. The parameters measured were low-density lipoprotein (LDL) particle phenotype, lipoprotein-associated phospholipase A2 (Lp-PLA2), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), sCD14, sCD163, monocyte chemoattractant protein-1(MCP-1), and asymmetric dimethylarginine (ADMA). A linear mixed model based on patient clusters was used to assess differences in biomarkers between the study groups and over time. The study population comprised 62 HIV-infected patients (group A, n = 31; group B, n = 31) and 22 controls. Age was 37 (30-43) years, and 81% were men. At baseline, the HIV-infected patients had a worse LDL particle phenotype and higher plasma concentration of sCD14, sCD163, hs-CRP, and LDL-Lp-PLA2 than the controls. At month 12, there was an increase in total cholesterol (p = 0.002), HDL-c (p = 0.003), and Apo A-I (p = 0.049) and a decrease in sCD14 (p = <0.001) and sCD163 (p<0.001), although only in group B. LDL particle size increased in group B at month 24 (p = 0.038). No changes were observed in group A or in the healthy controls. Common carotid intima-media thickness increased in HIV-infected patients at month 24 (Group A p = 0.053; group B p = 0.048). Plasma levels of sCD14, sCD163, and hs-CRP correlated with lipid values. In treatment-naive HIV-infected patients, initiation of c-ART was associated with an improvement in LDL particle phenotype and inflammatory/immune biomarkers, reaching values similar to those of the controls. HIV infection was associated with progression of carotid intima-media thickness.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32817629</pmid><doi>10.1371/journal.pone.0237739</doi><tpages>e0237739</tpages><orcidid>https://orcid.org/0000-0002-0047-1991</orcidid><orcidid>https://orcid.org/0000-0002-7028-1368</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-08, Vol.15 (8), p.e0237739-e0237739 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2435746038 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Apolipoproteins Arteriosclerosis Atherosclerosis Biochemistry Biological markers Biology and Life Sciences Biomarkers Biomedical research Blood lipids C-reactive protein Cardiovascular disease Care and treatment CD4 antigen Cholesterol Coronary vessels Development and progression Diabetes Diagnosis Drug therapy Evaluation Genotype & phenotype Health aspects High density lipoprotein Highly active antiretroviral therapy HIV HIV patients Human immunodeficiency virus Infections Infectious diseases Inflammation Interleukin Interleukin 6 Laboratories Lipids Lipoproteins Low density lipoprotein Medicine and Health Sciences Metabolism Methods Molecular biology Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes Patient outcomes Phenotypes Phospholipase Phospholipase A2 Plasma levels Population studies Proteins Studies Thickness Ultrasonic imaging Ultrasound |
| title | Lipids, biomarkers, and subclinical atherosclerosis in treatment-naive HIV patients starting or not starting antiretroviral therapy: Comparison with a healthy control group in a 2-year prospective study |
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