Lipids, biomarkers, and subclinical atherosclerosis in treatment-naive HIV patients starting or not starting antiretroviral therapy: Comparison with a healthy control group in a 2-year prospective study

To assess the effect of HIV infection and combined antiretroviral therapy (c-ART) on various proatherogenic biomarkers and lipids and to investigate their relationship with subclinical atherosclerosis in a cohort of treatment-naive HIV-infected patients. We performed a prospective, comparative, mult...

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Veröffentlicht in:	PloS one 2020-08, Vol.15 (8), p.e0237739-e0237739
Hauptverfasser:	Di Yacovo, Silvana, Saumoy, Maria, Sanchez-Quesada, Jose Luis, Navarro, Antonio, Sviridov, Dmitri, Javaloyas, Manuel, Vila, Ramon, Vernet, Anton, Low, Hann, Penafiel, Judith, Garcia, Benito, Ordonez-Llanos, Jordi, Podzamczer, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Apolipoproteins Arteriosclerosis Atherosclerosis Biochemistry Biological markers Biology and Life Sciences Biomarkers Biomedical research Blood lipids C-reactive protein Cardiovascular disease Care and treatment CD4 antigen Cholesterol Coronary vessels Development and progression Diabetes Diagnosis Drug therapy Evaluation Genotype & phenotype Health aspects High density lipoprotein Highly active antiretroviral therapy HIV HIV patients Human immunodeficiency virus Infections Infectious diseases Inflammation Interleukin Interleukin 6 Laboratories Lipids Lipoproteins Low density lipoprotein Medicine and Health Sciences Metabolism Methods Molecular biology Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes Patient outcomes Phenotypes Phospholipase Phospholipase A2 Plasma levels Population studies Proteins Studies Thickness Ultrasonic imaging Ultrasound
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Zusammenfassung:	To assess the effect of HIV infection and combined antiretroviral therapy (c-ART) on various proatherogenic biomarkers and lipids and to investigate their relationship with subclinical atherosclerosis in a cohort of treatment-naive HIV-infected patients. We performed a prospective, comparative, multicenter study of 2 groups of treatment-naive HIV-infected patients (group A, CD4>500 cells/[mu]L, not starting c-ART; and group B, CD4
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0237739