The effect of age and sex on selected hematologic and serum biochemical analytes in 4,804 elite endurance-trained sled dogs participating in the Iditarod Trail Sled Dog Race pre-race examination program
Endurance-trained sled dogs provide a unique translational model to characterize changes in hematologic and serum biochemical analytes due to the aging process. The primary objective of this study was to determine the effect of age and sex on specific hematologic and serum biochemical parameters in...
Gespeichert in:
| Veröffentlicht in: | PloS one 2020-08, Vol.15 (8), p.e0237706-e0237706 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0237706 |
|---|---|
| container_issue | 8 |
| container_start_page | e0237706 |
| container_title | PloS one |
| container_volume | 15 |
| creator | Connolly, Sara L Nelson, Stuart Jones, Tabitha Kahn, Julia Constable, Peter D |
| description | Endurance-trained sled dogs provide a unique translational model to characterize changes in hematologic and serum biochemical analytes due to the aging process. The primary objective of this study was to determine the effect of age and sex on specific hematologic and serum biochemical parameters in the endurance trained sled dog. Longitudinal and cross-sectional data were analyzed from 9,746 blood and serum samples from 4,804 dogs collected over 7 years as part of the Iditarod Trail Sled Dog Race pre-race examination program. Mixed models analysis was used for statistical analysis and P < 0.01 was considered significant. Dogs ranged from 1-12 years of age and 39% were female. Serum total calcium and phosphorus concentrations and white blood cell count decreased nonlinearly to asymptotic values by 6.6, 3.1, and 6.9 years of age, respectively, equivalent to estimated physiologic ages in human years of 44, 27, and 46 years. Serum glucose concentrations reached their lowest value at 7.8 years of age, equivalent to an estimated human physiologic age of 50 years, after which time the concentration increased. Serum globulin concentrations increased with age, but nonlinearly for females and linearly for males. Most sex-related differences were |
| doi_str_mv | 10.1371/journal.pone.0237706 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2435745858</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A633048899</galeid><doaj_id>oai_doaj_org_article_30a899459c0148c7a460fac1f8c88311</doaj_id><sourcerecordid>A633048899</sourcerecordid><originalsourceid>FETCH-LOGICAL-c669t-532bc871ae6e0ce0075480d3593317013dc2c75fc903eaf7e28324b4a095f30f3</originalsourceid><addsrcrecordid>eNqNk21r1TAUx4soTqffQDAgiIL3mjRpm74Rxny6MBhs07fh3PS0NyNNatLK9hX9VKZblV3ZCykk4Zzf-eec05wse8HomvGKvb_0U3Bg14N3uKY5rypaPsiesJrnqzKn_OGd80H2NMZLSgsuy_JxdsBzyaqyKJ9kvy52SLBtUY_EtwQ6JOAaEvGKeJc2mxzYkB32MHrrO6MXf5h6sjVeJ4_RYJMV7PWIkRhHxDtJBUFrxqTtmimA07gaAxiXtKJNS-O7SAYIo9FmgNG4bg4cUzKbxowQfEMuEm_J-Ux_9B05A41kCLgK8wGvoDcuBaYsh-C7AP2z7FELNuLzZT_Mvn3-dHH8dXVy-mVzfHSy0mVZj6uC51stKwZYItVIaVUISRte1JyzijLe6FxXRatryhHaCnPJc7EVQOui5bTlh9nLW93B-qiW3xBVLnhRiUIWMhGbW6LxcKmGYHoI18qDUTcGHzp1U7lFxSnIuhZFrSkTUlcgStqCZq3UUnLGktaH5bZp22Oj0aU-2j3RfY8zO9X5n6oSQhS8TAJvFoHgf0wYR9WbqNFacOinm7xLQVlRz-irf9D7q1uoDlIBxrU-3atnUXVUck6FTBUlan0Plb5mfjDpzbYm2fcC3u4FJGbEq7GDKUa1OT_7f_b0-z77-g67Q7DjLno7zU8n7oPiFtTBxxiw_dtkRtU8cn-6oeaRU8vI8d8I2x3W</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2435745858</pqid></control><display><type>article</type><title>The effect of age and sex on selected hematologic and serum biochemical analytes in 4,804 elite endurance-trained sled dogs participating in the Iditarod Trail Sled Dog Race pre-race examination program</title><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Connolly, Sara L ; Nelson, Stuart ; Jones, Tabitha ; Kahn, Julia ; Constable, Peter D</creator><contributor>Raverty, Stephen</contributor><creatorcontrib>Connolly, Sara L ; Nelson, Stuart ; Jones, Tabitha ; Kahn, Julia ; Constable, Peter D ; Raverty, Stephen</creatorcontrib><description>Endurance-trained sled dogs provide a unique translational model to characterize changes in hematologic and serum biochemical analytes due to the aging process. The primary objective of this study was to determine the effect of age and sex on specific hematologic and serum biochemical parameters in the endurance trained sled dog. Longitudinal and cross-sectional data were analyzed from 9,746 blood and serum samples from 4,804 dogs collected over 7 years as part of the Iditarod Trail Sled Dog Race pre-race examination program. Mixed models analysis was used for statistical analysis and P < 0.01 was considered significant. Dogs ranged from 1-12 years of age and 39% were female. Serum total calcium and phosphorus concentrations and white blood cell count decreased nonlinearly to asymptotic values by 6.6, 3.1, and 6.9 years of age, respectively, equivalent to estimated physiologic ages in human years of 44, 27, and 46 years. Serum glucose concentrations reached their lowest value at 7.8 years of age, equivalent to an estimated human physiologic age of 50 years, after which time the concentration increased. Serum globulin concentrations increased with age, but nonlinearly for females and linearly for males. Most sex-related differences were <5%; however, females had lower serum urea nitrogen (14.7%) and creatinine (7.3%) concentrations, lower serum alanine aminotransferase activity (16.6%), and higher serum total bilirubin concentration (12.8%) and platelet count (6.0%). The endurance-trained sled dog provides an excellent model to separate the physiologic effects of age from those of a sedentary lifestyle on hematologic and serum biochemical analytes.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0237706</identifier><identifier>PMID: 32817656</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Aerobic exercises ; Age ; Age (Biology) ; Age factors ; Aging ; Alanine ; Alanine transaminase ; Bilirubin ; Biochemistry ; Biology and Life Sciences ; Blood ; Calcium ; Clinical medicine ; Comparative analysis ; Creatinine ; Dogs ; Dogsledding ; Electrocardiography ; Equivalence ; Exercise ; Females ; Globulins ; Hematology ; Hypotheses ; Laboratories ; Leukocytes ; Medicine and Health Sciences ; Phosphorus ; Physical fitness ; Physiological aspects ; Research and Analysis Methods ; Semiconductors ; Sex ; Sex differences ; Sex differences (Biology) ; Sled dogs ; Sleds ; Statistical analysis ; Statistical methods ; Urea ; Veterinary colleges ; Veterinary medicine</subject><ispartof>PloS one, 2020-08, Vol.15 (8), p.e0237706-e0237706</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Connolly et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Connolly et al 2020 Connolly et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-532bc871ae6e0ce0075480d3593317013dc2c75fc903eaf7e28324b4a095f30f3</citedby><cites>FETCH-LOGICAL-c669t-532bc871ae6e0ce0075480d3593317013dc2c75fc903eaf7e28324b4a095f30f3</cites><orcidid>0000-0001-9233-0338</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444536/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444536/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids></links><search><contributor>Raverty, Stephen</contributor><creatorcontrib>Connolly, Sara L</creatorcontrib><creatorcontrib>Nelson, Stuart</creatorcontrib><creatorcontrib>Jones, Tabitha</creatorcontrib><creatorcontrib>Kahn, Julia</creatorcontrib><creatorcontrib>Constable, Peter D</creatorcontrib><title>The effect of age and sex on selected hematologic and serum biochemical analytes in 4,804 elite endurance-trained sled dogs participating in the Iditarod Trail Sled Dog Race pre-race examination program</title><title>PloS one</title><description>Endurance-trained sled dogs provide a unique translational model to characterize changes in hematologic and serum biochemical analytes due to the aging process. The primary objective of this study was to determine the effect of age and sex on specific hematologic and serum biochemical parameters in the endurance trained sled dog. Longitudinal and cross-sectional data were analyzed from 9,746 blood and serum samples from 4,804 dogs collected over 7 years as part of the Iditarod Trail Sled Dog Race pre-race examination program. Mixed models analysis was used for statistical analysis and P < 0.01 was considered significant. Dogs ranged from 1-12 years of age and 39% were female. Serum total calcium and phosphorus concentrations and white blood cell count decreased nonlinearly to asymptotic values by 6.6, 3.1, and 6.9 years of age, respectively, equivalent to estimated physiologic ages in human years of 44, 27, and 46 years. Serum glucose concentrations reached their lowest value at 7.8 years of age, equivalent to an estimated human physiologic age of 50 years, after which time the concentration increased. Serum globulin concentrations increased with age, but nonlinearly for females and linearly for males. Most sex-related differences were <5%; however, females had lower serum urea nitrogen (14.7%) and creatinine (7.3%) concentrations, lower serum alanine aminotransferase activity (16.6%), and higher serum total bilirubin concentration (12.8%) and platelet count (6.0%). The endurance-trained sled dog provides an excellent model to separate the physiologic effects of age from those of a sedentary lifestyle on hematologic and serum biochemical analytes.</description><subject>Aerobic exercises</subject><subject>Age</subject><subject>Age (Biology)</subject><subject>Age factors</subject><subject>Aging</subject><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Bilirubin</subject><subject>Biochemistry</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Calcium</subject><subject>Clinical medicine</subject><subject>Comparative analysis</subject><subject>Creatinine</subject><subject>Dogs</subject><subject>Dogsledding</subject><subject>Electrocardiography</subject><subject>Equivalence</subject><subject>Exercise</subject><subject>Females</subject><subject>Globulins</subject><subject>Hematology</subject><subject>Hypotheses</subject><subject>Laboratories</subject><subject>Leukocytes</subject><subject>Medicine and Health Sciences</subject><subject>Phosphorus</subject><subject>Physical fitness</subject><subject>Physiological aspects</subject><subject>Research and Analysis Methods</subject><subject>Semiconductors</subject><subject>Sex</subject><subject>Sex differences</subject><subject>Sex differences (Biology)</subject><subject>Sled dogs</subject><subject>Sleds</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Urea</subject><subject>Veterinary colleges</subject><subject>Veterinary medicine</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk21r1TAUx4soTqffQDAgiIL3mjRpm74Rxny6MBhs07fh3PS0NyNNatLK9hX9VKZblV3ZCykk4Zzf-eec05wse8HomvGKvb_0U3Bg14N3uKY5rypaPsiesJrnqzKn_OGd80H2NMZLSgsuy_JxdsBzyaqyKJ9kvy52SLBtUY_EtwQ6JOAaEvGKeJc2mxzYkB32MHrrO6MXf5h6sjVeJ4_RYJMV7PWIkRhHxDtJBUFrxqTtmimA07gaAxiXtKJNS-O7SAYIo9FmgNG4bg4cUzKbxowQfEMuEm_J-Ux_9B05A41kCLgK8wGvoDcuBaYsh-C7AP2z7FELNuLzZT_Mvn3-dHH8dXVy-mVzfHSy0mVZj6uC51stKwZYItVIaVUISRte1JyzijLe6FxXRatryhHaCnPJc7EVQOui5bTlh9nLW93B-qiW3xBVLnhRiUIWMhGbW6LxcKmGYHoI18qDUTcGHzp1U7lFxSnIuhZFrSkTUlcgStqCZq3UUnLGktaH5bZp22Oj0aU-2j3RfY8zO9X5n6oSQhS8TAJvFoHgf0wYR9WbqNFacOinm7xLQVlRz-irf9D7q1uoDlIBxrU-3atnUXVUck6FTBUlan0Plb5mfjDpzbYm2fcC3u4FJGbEq7GDKUa1OT_7f_b0-z77-g67Q7DjLno7zU8n7oPiFtTBxxiw_dtkRtU8cn-6oeaRU8vI8d8I2x3W</recordid><startdate>20200820</startdate><enddate>20200820</enddate><creator>Connolly, Sara L</creator><creator>Nelson, Stuart</creator><creator>Jones, Tabitha</creator><creator>Kahn, Julia</creator><creator>Constable, Peter D</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-9233-0338</orcidid></search><sort><creationdate>20200820</creationdate><title>The effect of age and sex on selected hematologic and serum biochemical analytes in 4,804 elite endurance-trained sled dogs participating in the Iditarod Trail Sled Dog Race pre-race examination program</title><author>Connolly, Sara L ; Nelson, Stuart ; Jones, Tabitha ; Kahn, Julia ; Constable, Peter D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-532bc871ae6e0ce0075480d3593317013dc2c75fc903eaf7e28324b4a095f30f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aerobic exercises</topic><topic>Age</topic><topic>Age (Biology)</topic><topic>Age factors</topic><topic>Aging</topic><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Bilirubin</topic><topic>Biochemistry</topic><topic>Biology and Life Sciences</topic><topic>Blood</topic><topic>Calcium</topic><topic>Clinical medicine</topic><topic>Comparative analysis</topic><topic>Creatinine</topic><topic>Dogs</topic><topic>Dogsledding</topic><topic>Electrocardiography</topic><topic>Equivalence</topic><topic>Exercise</topic><topic>Females</topic><topic>Globulins</topic><topic>Hematology</topic><topic>Hypotheses</topic><topic>Laboratories</topic><topic>Leukocytes</topic><topic>Medicine and Health Sciences</topic><topic>Phosphorus</topic><topic>Physical fitness</topic><topic>Physiological aspects</topic><topic>Research and Analysis Methods</topic><topic>Semiconductors</topic><topic>Sex</topic><topic>Sex differences</topic><topic>Sex differences (Biology)</topic><topic>Sled dogs</topic><topic>Sleds</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Urea</topic><topic>Veterinary colleges</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Connolly, Sara L</creatorcontrib><creatorcontrib>Nelson, Stuart</creatorcontrib><creatorcontrib>Jones, Tabitha</creatorcontrib><creatorcontrib>Kahn, Julia</creatorcontrib><creatorcontrib>Constable, Peter D</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Connolly, Sara L</au><au>Nelson, Stuart</au><au>Jones, Tabitha</au><au>Kahn, Julia</au><au>Constable, Peter D</au><au>Raverty, Stephen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of age and sex on selected hematologic and serum biochemical analytes in 4,804 elite endurance-trained sled dogs participating in the Iditarod Trail Sled Dog Race pre-race examination program</atitle><jtitle>PloS one</jtitle><date>2020-08-20</date><risdate>2020</risdate><volume>15</volume><issue>8</issue><spage>e0237706</spage><epage>e0237706</epage><pages>e0237706-e0237706</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Endurance-trained sled dogs provide a unique translational model to characterize changes in hematologic and serum biochemical analytes due to the aging process. The primary objective of this study was to determine the effect of age and sex on specific hematologic and serum biochemical parameters in the endurance trained sled dog. Longitudinal and cross-sectional data were analyzed from 9,746 blood and serum samples from 4,804 dogs collected over 7 years as part of the Iditarod Trail Sled Dog Race pre-race examination program. Mixed models analysis was used for statistical analysis and P < 0.01 was considered significant. Dogs ranged from 1-12 years of age and 39% were female. Serum total calcium and phosphorus concentrations and white blood cell count decreased nonlinearly to asymptotic values by 6.6, 3.1, and 6.9 years of age, respectively, equivalent to estimated physiologic ages in human years of 44, 27, and 46 years. Serum glucose concentrations reached their lowest value at 7.8 years of age, equivalent to an estimated human physiologic age of 50 years, after which time the concentration increased. Serum globulin concentrations increased with age, but nonlinearly for females and linearly for males. Most sex-related differences were <5%; however, females had lower serum urea nitrogen (14.7%) and creatinine (7.3%) concentrations, lower serum alanine aminotransferase activity (16.6%), and higher serum total bilirubin concentration (12.8%) and platelet count (6.0%). The endurance-trained sled dog provides an excellent model to separate the physiologic effects of age from those of a sedentary lifestyle on hematologic and serum biochemical analytes.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32817656</pmid><doi>10.1371/journal.pone.0237706</doi><tpages>e0237706</tpages><orcidid>https://orcid.org/0000-0001-9233-0338</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-08, Vol.15 (8), p.e0237706-e0237706 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2435745858 |
| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aerobic exercises Age Age (Biology) Age factors Aging Alanine Alanine transaminase Bilirubin Biochemistry Biology and Life Sciences Blood Calcium Clinical medicine Comparative analysis Creatinine Dogs Dogsledding Electrocardiography Equivalence Exercise Females Globulins Hematology Hypotheses Laboratories Leukocytes Medicine and Health Sciences Phosphorus Physical fitness Physiological aspects Research and Analysis Methods Semiconductors Sex Sex differences Sex differences (Biology) Sled dogs Sleds Statistical analysis Statistical methods Urea Veterinary colleges Veterinary medicine |
| title | The effect of age and sex on selected hematologic and serum biochemical analytes in 4,804 elite endurance-trained sled dogs participating in the Iditarod Trail Sled Dog Race pre-race examination program |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T16%3A26%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effect%20of%20age%20and%20sex%20on%20selected%20hematologic%20and%20serum%20biochemical%20analytes%20in%204,804%20elite%20endurance-trained%20sled%20dogs%20participating%20in%20the%20Iditarod%20Trail%20Sled%20Dog%20Race%20pre-race%20examination%20program&rft.jtitle=PloS%20one&rft.au=Connolly,%20Sara%20L&rft.date=2020-08-20&rft.volume=15&rft.issue=8&rft.spage=e0237706&rft.epage=e0237706&rft.pages=e0237706-e0237706&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0237706&rft_dat=%3Cgale_plos_%3EA633048899%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2435745858&rft_id=info:pmid/32817656&rft_galeid=A633048899&rft_doaj_id=oai_doaj_org_article_30a899459c0148c7a460fac1f8c88311&rfr_iscdi=true |