Down-regulation of tenascin-C inhibits breast cancer cells development by cell growth, migration, and adhesion impairment

Tenascin-C (TNC) is an extracellular matrix (ECM) glycoprotein that plays an important role in cell proliferation, migration, and tumour invasion in various cancers. TNC is one of the main protein overexpressed in breast cancer, indicating a role for this ECM molecule in cancer pathology. In this st...

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Veröffentlicht in:	PloS one 2020-08, Vol.15 (8), p.e0237889
Hauptverfasser:	Wawrzyniak, Dariusz, Grabowska, Małgorzata, Głodowicz, Paweł, Kuczyński, Konrad, Kuczyńska, Bogna, Fedoruk-Wyszomirska, Agnieszka, Rolle, Katarzyna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Biology and Life Sciences Biomarkers, Tumor - genetics Brain cancer Brain tumors Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer cells Cancer therapies Caspase Cell activation Cell adhesion & migration Cell Adhesion - drug effects Cell Adhesion - genetics Cell culture Cell cycle Cell development (Biology) Cell migration Cell Movement - drug effects Cell Movement - genetics Cell proliferation Cell Proliferation - drug effects Cell Proliferation - genetics Development and progression Disease-Free Survival Double-stranded RNA Epithelial-Mesenchymal Transition - drug effects Extracellular matrix Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Genomes Glycoproteins Health aspects Homology Humans MCF-7 Cells Medical prognosis Medicine and Health Sciences Mesenchyme mRNA Mutation Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Nucleotide sequence Patients Phenotypes Prognosis Proteins Research and Analysis Methods RNA, Double-Stranded - genetics RNA, Double-Stranded - pharmacology Stem cells Survival Tenascin Tenascin - antagonists & inhibitors Tenascin - genetics Tenascin C Tumor cell lines Tumors
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