$Development of a polygenic risk score to improve screening for fracture risk: A genetic risk prediction study$

Development of a polygenic risk score to improve screening for fracture risk: A genetic risk prediction study

Since screening programs identify only a small proportion of the population as eligible for an intervention, genomic prediction of heritable risk factors could decrease the number needing to be screened by removing individuals at low genetic risk. We therefore tested whether a polygenic risk score f...

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Veröffentlicht in:	PLoS medicine 2020-07, Vol.17 (7), p.e1003152
Hauptverfasser:	Forgetta, Vincenzo, Keller-Baruch, Julyan, Forest, Marie, Durand, Audrey, Bhatnagar, Sahir, Kemp, John P, Nethander, Maria, Evans, Daniel, Morris, John A, Kiel, Douglas P, Rivadeneira, Fernando, Johansson, Helena, Harvey, Nicholas C, Mellström, Dan, Karlsson, Magnus, Cooper, Cyrus, Evans, David M, Clarke, Robert, Kanis, John A, Orwoll, Eric, McCloskey, Eugene V, Ohlsson, Claes, Pineau, Joelle, Leslie, William D, Greenwood, Celia M T, Richards, J Brent
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Arthritis association Basic Medicine Biology and Life Sciences Biomedical research Bone Density Bone diseases Bone mineral density Calcaneus - diagnostic imaging Clinical Medicine Cohort Studies Computer science cost-effectiveness Councils Databases, Genetic diagnosis Epidemiology Female Fractures Fractures (Injuries) General & Internal Medicine Genetic aspects Genetic Predisposition to Disease Genetics Genome-Wide Association Study Genomes Genomics Health risk assessment Health sciences Health screening Heel - diagnostic imaging Hospitals Humans Internal medicine Klinisk medicin Machine Learning Male management Mass Screening - methods Medical and Health Sciences Medical Genetics Medical research Medicin och hälsovetenskap Medicine Medicine and Health Sciences Medicinsk genetik Medicinska och farmaceutiska grundvetenskaper Metabolism Middle Aged Multifactorial Inheritance Nutrition older women Orthopedics Ortopedi Osteoporosis Osteoporosis - genetics osteoporotic fractures Osteoporotic Fractures - genetics Osteoporotic Fractures - prevention & control Population Prediction models quantitative ultrasound Research and Analysis Methods Risk assessment Risk Assessment - methods Risk Factors Software strategies uk biobank Ultrasonography Ultrasound United Kingdom
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