Can photobiomodulation therapy be an alternative to pharmacological therapies in decreasing the progression of skeletal muscle impairments of mdx mice?
Objective To compare the effects of photobiomodulation therapy (PBMT) and pharmacological therapy (glucocorticoids and non-steroidal anti-inflammatory drugs) applied alone and in different combinations in mdx mice. Methods The animals were randomized and divided into seven experimental groups treate...
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| creator | Tomazoni, Shaiane Silva Casalechi, Heliodora Leao Ferreira, Cheila de Sousa Bacelar Serra, Andrey Jorge Dellê, Humberto Brito, Rodrigo Barbosa de Oliveira de Melo, Brunno Lemes Vanin, Adriane Aver Ribeiro, Neide Firmo Pereira, Amanda Lima Monteiro, Kadma Karenina Damasceno Soares Marcos, Rodrigo Labat de Carvalho, Paulo de Tarso Camillo Frigo, Lucio Leal-Junior, Ernesto Cesar Pinto |
| description | Objective To compare the effects of photobiomodulation therapy (PBMT) and pharmacological therapy (glucocorticoids and non-steroidal anti-inflammatory drugs) applied alone and in different combinations in mdx mice. Methods The animals were randomized and divided into seven experimental groups treated with placebo, PBMT, prednisone, non-steroidal anti-inflammatory drug (NSAIDs), PBMT plus prednisone and PBMT plus NSAID. Wild type animals were used as control. All treatments were performed during 14 consecutive weeks. Muscular morphology, protein expression of dystrophin and functional performance were assessed at the end of the last treatment. Results Both treatments with prednisone and PBMT applied alone or combined, were effective in preserving muscular morphology. In addition, the treatments with PBMT (p = 0.0005), PBMT plus prednisone (p = 0.0048) and PBMT plus NSAID (p = 0.0021) increased dystrophin gene expression compared to placebo-control group. However, in the functional performance the PBMT presented better results compared to glucocorticoids (p |
| doi_str_mv | 10.1371/journal.pone.0236689 |
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Methods The animals were randomized and divided into seven experimental groups treated with placebo, PBMT, prednisone, non-steroidal anti-inflammatory drug (NSAIDs), PBMT plus prednisone and PBMT plus NSAID. Wild type animals were used as control. All treatments were performed during 14 consecutive weeks. Muscular morphology, protein expression of dystrophin and functional performance were assessed at the end of the last treatment. Results Both treatments with prednisone and PBMT applied alone or combined, were effective in preserving muscular morphology. In addition, the treatments with PBMT (p = 0.0005), PBMT plus prednisone (p = 0.0048) and PBMT plus NSAID (p = 0.0021) increased dystrophin gene expression compared to placebo-control group. However, in the functional performance the PBMT presented better results compared to glucocorticoids (p<0.0001). In contrast, the use of NSAIDs did not appear to add benefits to skeletal muscle tissue in mdx mice. Conclusion We believe that the promising and optimistic results about the PBMT in skeletal muscle of mdx mice may in the future contribute to this therapy to be considered a safe alternative for patients with Duchenne Muscular Dystrophy (DMD) in a washout period (between treatment periods with glucocorticoids), allowing them to remain receiving effective and safe treatment in this period, avoiding at this way periods without administration of any treatment.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0236689</identifier><identifier>PMID: 32785240</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Animal tissues ; Animals ; Anti-inflammatory agents ; Biology and Life Sciences ; Care and treatment ; Drug dosages ; Drug therapy ; Duchenne's muscular dystrophy ; Dystrophin ; Dystrophy ; Gene expression ; Glucocorticoids ; Inflammation ; Laboratories ; Light therapy ; Medical research ; Medicine ; Medicine and Health Sciences ; Methods ; Morphology ; Muscles ; Muscular diseases ; Muscular dystrophy ; Musculoskeletal system ; Nonsteroidal anti-inflammatory drugs ; Pharmacology ; Phototherapy ; Placebo effect ; Prednisone ; Primary care ; Protein expression ; Proteins ; Public health ; Rehabilitation ; Research and Analysis Methods ; Rodents ; Skeletal muscle ; Testing ; Therapy ; Washout</subject><ispartof>PloS one, 2020-08, Vol.15 (8), p.e0236689-e0236689</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Tomazoni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Tomazoni et al 2020 Tomazoni et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-2eeab4eafbcf3917b3d7b37b2cde3e99c37f968a3b7b004b8347a1d4992079a63</citedby><cites>FETCH-LOGICAL-c669t-2eeab4eafbcf3917b3d7b37b2cde3e99c37f968a3b7b004b8347a1d4992079a63</cites><orcidid>0000-0001-6393-7616 ; 0000-0001-6072-3671 ; 0000-0003-1564-7280</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423120/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423120/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2919,23857,27915,27916,53782,53784,79361,79362</link.rule.ids></links><search><contributor>Mohan, Subburaman</contributor><creatorcontrib>Tomazoni, Shaiane Silva</creatorcontrib><creatorcontrib>Casalechi, Heliodora Leao</creatorcontrib><creatorcontrib>Ferreira, Cheila de Sousa Bacelar</creatorcontrib><creatorcontrib>Serra, Andrey Jorge</creatorcontrib><creatorcontrib>Dellê, Humberto</creatorcontrib><creatorcontrib>Brito, Rodrigo Barbosa de Oliveira</creatorcontrib><creatorcontrib>de Melo, Brunno Lemes</creatorcontrib><creatorcontrib>Vanin, Adriane Aver</creatorcontrib><creatorcontrib>Ribeiro, Neide Firmo</creatorcontrib><creatorcontrib>Pereira, Amanda Lima</creatorcontrib><creatorcontrib>Monteiro, Kadma Karenina Damasceno Soares</creatorcontrib><creatorcontrib>Marcos, Rodrigo Labat</creatorcontrib><creatorcontrib>de Carvalho, Paulo de Tarso Camillo</creatorcontrib><creatorcontrib>Frigo, Lucio</creatorcontrib><creatorcontrib>Leal-Junior, Ernesto Cesar Pinto</creatorcontrib><title>Can photobiomodulation therapy be an alternative to pharmacological therapies in decreasing the progression of skeletal muscle impairments of mdx mice?</title><title>PloS one</title><description>Objective To compare the effects of photobiomodulation therapy (PBMT) and pharmacological therapy (glucocorticoids and non-steroidal anti-inflammatory drugs) applied alone and in different combinations in mdx mice. Methods The animals were randomized and divided into seven experimental groups treated with placebo, PBMT, prednisone, non-steroidal anti-inflammatory drug (NSAIDs), PBMT plus prednisone and PBMT plus NSAID. Wild type animals were used as control. All treatments were performed during 14 consecutive weeks. Muscular morphology, protein expression of dystrophin and functional performance were assessed at the end of the last treatment. Results Both treatments with prednisone and PBMT applied alone or combined, were effective in preserving muscular morphology. In addition, the treatments with PBMT (p = 0.0005), PBMT plus prednisone (p = 0.0048) and PBMT plus NSAID (p = 0.0021) increased dystrophin gene expression compared to placebo-control group. However, in the functional performance the PBMT presented better results compared to glucocorticoids (p<0.0001). In contrast, the use of NSAIDs did not appear to add benefits to skeletal muscle tissue in mdx mice. Conclusion We believe that the promising and optimistic results about the PBMT in skeletal muscle of mdx mice may in the future contribute to this therapy to be considered a safe alternative for patients with Duchenne Muscular Dystrophy (DMD) in a washout period (between treatment periods with glucocorticoids), allowing them to remain receiving effective and safe treatment in this period, avoiding at this way periods without administration of any treatment.</description><subject>Animal tissues</subject><subject>Animals</subject><subject>Anti-inflammatory agents</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Duchenne's muscular dystrophy</subject><subject>Dystrophin</subject><subject>Dystrophy</subject><subject>Gene expression</subject><subject>Glucocorticoids</subject><subject>Inflammation</subject><subject>Laboratories</subject><subject>Light therapy</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Morphology</subject><subject>Muscles</subject><subject>Muscular diseases</subject><subject>Muscular dystrophy</subject><subject>Musculoskeletal system</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Pharmacology</subject><subject>Phototherapy</subject><subject>Placebo effect</subject><subject>Prednisone</subject><subject>Primary care</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Public health</subject><subject>Rehabilitation</subject><subject>Research and Analysis Methods</subject><subject>Rodents</subject><subject>Skeletal muscle</subject><subject>Testing</subject><subject>Therapy</subject><subject>Washout</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tq3DAQhk1padK0b1CooVDai93Kki3ZNy1h6WEhEOjpVugw9iqVLUeSQ_Ikfd3KWbdkSy6KEDKjb_7xjGay7HmB1gVhxdsLN_lB2PXoBlgjTCitmwfZcdEQvKIYkYd3vo-yJyFcIFSRmtLH2RHBrK5wiY6zXxsx5OPORSeN652erIjGDXncgRfjTS4hT4CwEVKwaK4gjy7xwvdCOes6o4RdYAMhN0OuQXkQwQzdbM9H7zoPIcyirs3DT7AQk08_BWUhN_0ojO9hiGG-7vV13hsF759mj1phAzxbzpPs-8cP3zafV2fnn7ab07OVorSJKwwgZAmilaolTcEk0WkziZUGAk2jCGsbWgsimUSolDUpmSh02TQYsUZQcpK92OuO1gW-1DRwXBKCK4RRkYjtntBOXPDRm174G-6E4bcG5zsufDQpGS6qopaIAJQYl5pqCcCqQslKa8TqFiWtd0u0SfagVUrbC3sgengzmB3v3BVnJSYFngVeLwLeXU4QIu9NUGCtGMBNt_9doooVmCX05T_o_dktVCdSAmZoXYqrZlF-SgkmiJZ0ptb3UGlpSK-VGrA1yX7g8ObAITERrmMnphD49uuX_2fPfxyyr-6wO0iNuQvOTnPPhkOw3IPKuxA8tH-LXCA-z8-favB5fvgyP-Q3U58PYw</recordid><startdate>20200812</startdate><enddate>20200812</enddate><creator>Tomazoni, 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Soares</au><au>Marcos, Rodrigo Labat</au><au>de Carvalho, Paulo de Tarso Camillo</au><au>Frigo, Lucio</au><au>Leal-Junior, Ernesto Cesar Pinto</au><au>Mohan, Subburaman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can photobiomodulation therapy be an alternative to pharmacological therapies in decreasing the progression of skeletal muscle impairments of mdx mice?</atitle><jtitle>PloS one</jtitle><date>2020-08-12</date><risdate>2020</risdate><volume>15</volume><issue>8</issue><spage>e0236689</spage><epage>e0236689</epage><pages>e0236689-e0236689</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Objective To compare the effects of photobiomodulation therapy (PBMT) and pharmacological therapy (glucocorticoids and non-steroidal anti-inflammatory drugs) applied alone and in different combinations in mdx mice. Methods The animals were randomized and divided into seven experimental groups treated with placebo, PBMT, prednisone, non-steroidal anti-inflammatory drug (NSAIDs), PBMT plus prednisone and PBMT plus NSAID. Wild type animals were used as control. All treatments were performed during 14 consecutive weeks. Muscular morphology, protein expression of dystrophin and functional performance were assessed at the end of the last treatment. Results Both treatments with prednisone and PBMT applied alone or combined, were effective in preserving muscular morphology. In addition, the treatments with PBMT (p = 0.0005), PBMT plus prednisone (p = 0.0048) and PBMT plus NSAID (p = 0.0021) increased dystrophin gene expression compared to placebo-control group. However, in the functional performance the PBMT presented better results compared to glucocorticoids (p<0.0001). In contrast, the use of NSAIDs did not appear to add benefits to skeletal muscle tissue in mdx mice. Conclusion We believe that the promising and optimistic results about the PBMT in skeletal muscle of mdx mice may in the future contribute to this therapy to be considered a safe alternative for patients with Duchenne Muscular Dystrophy (DMD) in a washout period (between treatment periods with glucocorticoids), allowing them to remain receiving effective and safe treatment in this period, avoiding at this way periods without administration of any treatment.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32785240</pmid><doi>10.1371/journal.pone.0236689</doi><tpages>e0236689</tpages><orcidid>https://orcid.org/0000-0001-6393-7616</orcidid><orcidid>https://orcid.org/0000-0001-6072-3671</orcidid><orcidid>https://orcid.org/0000-0003-1564-7280</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-08, Vol.15 (8), p.e0236689-e0236689 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2433250201 |
| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animal tissues Animals Anti-inflammatory agents Biology and Life Sciences Care and treatment Drug dosages Drug therapy Duchenne's muscular dystrophy Dystrophin Dystrophy Gene expression Glucocorticoids Inflammation Laboratories Light therapy Medical research Medicine Medicine and Health Sciences Methods Morphology Muscles Muscular diseases Muscular dystrophy Musculoskeletal system Nonsteroidal anti-inflammatory drugs Pharmacology Phototherapy Placebo effect Prednisone Primary care Protein expression Proteins Public health Rehabilitation Research and Analysis Methods Rodents Skeletal muscle Testing Therapy Washout |
| title | Can photobiomodulation therapy be an alternative to pharmacological therapies in decreasing the progression of skeletal muscle impairments of mdx mice? |
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