Hippocampal subfield volumes in abstinent men and women with a history of alcohol use disorder
Alcohol Use Disorder (AUD) has been associated with abnormalities in hippocampal volumes, but these relationships have not been fully explored with respect to sub-regional volumes, nor in association with individual characteristics such as age, gender differences, drinking history, and memory. The p...
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| description | Alcohol Use Disorder (AUD) has been associated with abnormalities in hippocampal volumes, but these relationships have not been fully explored with respect to sub-regional volumes, nor in association with individual characteristics such as age, gender differences, drinking history, and memory. The present study examined the impact of those variables in relation to hippocampal subfield volumes in abstinent men and women with a history of AUD. Using Magnetic Resonance Imaging at 3 Tesla, we obtained brain images from 67 participants with AUD (31 women) and 64 nonalcoholic control (NC) participants (31 women). The average duration of the most recent period of sobriety for AUD participants was 7.1 years. We used Freesurfer 6.0 to segment the hippocampus into 12 regions. These were imputed into statistical models to examine the relationships of brain volume with AUD group, age, gender, memory, and drinking history. Interactions with gender and age were of particular interest. Compared to the NC group, the AUD group had approximately 5% smaller subiculum, CA1, molecular layer, and hippocampal tail regions. Age was negatively associated with volumes for the AUD group in the subiculum and the hippocampal tail, but no significant interactions with gender were identified. The relationships for delayed and immediate memory with hippocampal tail volume differed for AUD and NC groups: Higher scores on tests of immediate and delayed memory were associated with smaller volumes in the AUD group, but larger volumes in the NC group. Length of sobriety was associated with decreasing CA1 volume in women (0.19% per year) and increasing volume size in men (0.38% per year). The course of abstinence on CA1 volume differed for men and women, and the differential relationships of subfield volumes to age and memory could indicate a distinction in the impact of AUD on functions of the hippocampal tail. These findings confirm and extend evidence that AUD, age, gender, memory, and abstinence differentially impact volumes of component parts of the hippocampus. |
| doi_str_mv | 10.1371/journal.pone.0236641 |
| format | Article |
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The present study examined the impact of those variables in relation to hippocampal subfield volumes in abstinent men and women with a history of AUD. Using Magnetic Resonance Imaging at 3 Tesla, we obtained brain images from 67 participants with AUD (31 women) and 64 nonalcoholic control (NC) participants (31 women). The average duration of the most recent period of sobriety for AUD participants was 7.1 years. We used Freesurfer 6.0 to segment the hippocampus into 12 regions. These were imputed into statistical models to examine the relationships of brain volume with AUD group, age, gender, memory, and drinking history. Interactions with gender and age were of particular interest. Compared to the NC group, the AUD group had approximately 5% smaller subiculum, CA1, molecular layer, and hippocampal tail regions. Age was negatively associated with volumes for the AUD group in the subiculum and the hippocampal tail, but no significant interactions with gender were identified. The relationships for delayed and immediate memory with hippocampal tail volume differed for AUD and NC groups: Higher scores on tests of immediate and delayed memory were associated with smaller volumes in the AUD group, but larger volumes in the NC group. Length of sobriety was associated with decreasing CA1 volume in women (0.19% per year) and increasing volume size in men (0.38% per year). The course of abstinence on CA1 volume differed for men and women, and the differential relationships of subfield volumes to age and memory could indicate a distinction in the impact of AUD on functions of the hippocampal tail. These findings confirm and extend evidence that AUD, age, gender, memory, and abstinence differentially impact volumes of component parts of the hippocampus.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0236641</identifier><identifier>PMID: 32776986</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Abstinence ; Adult ; Age ; Aged ; Alcohol Abstinence ; Alcohol use ; Alcoholism ; Alcoholism - pathology ; Biology and Life Sciences ; Brain ; Drinking ; Drinking behavior ; Female ; Gender ; Gender aspects ; Hippocampus ; Hippocampus (Brain) ; Hippocampus - pathology ; Humans ; Magnetic resonance ; Magnetic Resonance Imaging ; Male ; Mathematical models ; Medicine ; Medicine and Health Sciences ; Memory ; Men ; Middle Aged ; Neuroimaging ; Organ Size ; Physical Sciences ; Physiological aspects ; Research and Analysis Methods ; Sex differences ; Statistical analysis ; Statistical models ; Subiculum ; Supervision ; Tails ; Women</subject><ispartof>PloS one, 2020-08, Vol.15 (8), p.e0236641</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. 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subfield volumes in abstinent men and women with a history of alcohol use disorder</title><author>Sawyer, Kayle S ; Adra, Noor ; Salz, Daniel M ; Kemppainen, Maaria I ; Ruiz, Susan M ; Harris, Gordon J ; Oscar-Berman, Marlene</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-b1233e68a9cb68855d2714aa0b39ba611e3a024bf4af95c296d05f24df9d3af13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abnormalities</topic><topic>Abstinence</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Alcohol Abstinence</topic><topic>Alcohol use</topic><topic>Alcoholism</topic><topic>Alcoholism - pathology</topic><topic>Biology and Life Sciences</topic><topic>Brain</topic><topic>Drinking</topic><topic>Drinking behavior</topic><topic>Female</topic><topic>Gender</topic><topic>Gender aspects</topic><topic>Hippocampus</topic><topic>Hippocampus (Brain)</topic><topic>Hippocampus 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Marlene</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hippocampal subfield volumes in abstinent men and women with a history of alcohol use disorder</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-08-10</date><risdate>2020</risdate><volume>15</volume><issue>8</issue><spage>e0236641</spage><pages>e0236641-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Alcohol Use Disorder (AUD) has been associated with abnormalities in hippocampal volumes, but these relationships have not been fully explored with respect to sub-regional volumes, nor in association with individual characteristics such as age, gender differences, drinking history, and memory. The present study examined the impact of those variables in relation to hippocampal subfield volumes in abstinent men and women with a history of AUD. Using Magnetic Resonance Imaging at 3 Tesla, we obtained brain images from 67 participants with AUD (31 women) and 64 nonalcoholic control (NC) participants (31 women). The average duration of the most recent period of sobriety for AUD participants was 7.1 years. We used Freesurfer 6.0 to segment the hippocampus into 12 regions. These were imputed into statistical models to examine the relationships of brain volume with AUD group, age, gender, memory, and drinking history. Interactions with gender and age were of particular interest. Compared to the NC group, the AUD group had approximately 5% smaller subiculum, CA1, molecular layer, and hippocampal tail regions. Age was negatively associated with volumes for the AUD group in the subiculum and the hippocampal tail, but no significant interactions with gender were identified. The relationships for delayed and immediate memory with hippocampal tail volume differed for AUD and NC groups: Higher scores on tests of immediate and delayed memory were associated with smaller volumes in the AUD group, but larger volumes in the NC group. Length of sobriety was associated with decreasing CA1 volume in women (0.19% per year) and increasing volume size in men (0.38% per year). The course of abstinence on CA1 volume differed for men and women, and the differential relationships of subfield volumes to age and memory could indicate a distinction in the impact of AUD on functions of the hippocampal tail. These findings confirm and extend evidence that AUD, age, gender, memory, and abstinence differentially impact volumes of component parts of the hippocampus.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32776986</pmid><doi>10.1371/journal.pone.0236641</doi><tpages>e0236641</tpages><orcidid>https://orcid.org/0000-0001-7767-5688</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abnormalities Abstinence Adult Age Aged Alcohol Abstinence Alcohol use Alcoholism Alcoholism - pathology Biology and Life Sciences Brain Drinking Drinking behavior Female Gender Gender aspects Hippocampus Hippocampus (Brain) Hippocampus - pathology Humans Magnetic resonance Magnetic Resonance Imaging Male Mathematical models Medicine Medicine and Health Sciences Memory Men Middle Aged Neuroimaging Organ Size Physical Sciences Physiological aspects Research and Analysis Methods Sex differences Statistical analysis Statistical models Subiculum Supervision Tails Women |
| title | Hippocampal subfield volumes in abstinent men and women with a history of alcohol use disorder |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T14%3A56%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hippocampal%20subfield%20volumes%20in%20abstinent%20men%20and%20women%20with%20a%20history%20of%20alcohol%20use%20disorder&rft.jtitle=PloS%20one&rft.au=Sawyer,%20Kayle%20S&rft.date=2020-08-10&rft.volume=15&rft.issue=8&rft.spage=e0236641&rft.pages=e0236641-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0236641&rft_dat=%3Cgale_plos_%3EA632112968%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2432419138&rft_id=info:pmid/32776986&rft_galeid=A632112968&rft_doaj_id=oai_doaj_org_article_2f1bb7acb17f43cc91e4056cdfae8873&rfr_iscdi=true |