Primary break-up and atomization characteristics of a nasal spray
The primary objective of this research was to extract the essential information needed for setting atomization break up models, specifically, the Linear Instability Sheet Atomization (LISA) breakup model, and alternative hollow cone models. A secondary objective was to gain visualization and insight...
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| Veröffentlicht in: | PloS one 2020-08, Vol.15 (8), p.e0236063-e0236063 |
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| creator | Shrestha, Kendra Van Strien, James Singh, Narinder Inthavong, Kiao Sznitman, Josué |
| description | The primary objective of this research was to extract the essential information needed for setting atomization break up models, specifically, the Linear Instability Sheet Atomization (LISA) breakup model, and alternative hollow cone models. A secondary objective was to gain visualization and insight into the atomization break up mechanism caused by the effects of viscosity and surface tension on primary break-up, sheet disintegration, ligament and droplet formation. High speed imaging was used to capture the near-nozzle characteristics for water and drug formulations. This demonstrated more rapid atomization for lower viscosities. Image processing was used to analyze the near-nozzle spray characteristics during the primary break-up of the liquid sheet into ligament formation. Edges of the liquid sheet, spray break-up length, break-up radius, cone angle and dispersion angle were obtained. Spray characteristics pertinent for primary breakup modelling were determined from high speed imaging of multiple spray actuations. The results have established input data for computational modelling involving parametrical analysis of nasal drug delivery. |
| doi_str_mv | 10.1371/journal.pone.0236063 |
| format | Article |
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A secondary objective was to gain visualization and insight into the atomization break up mechanism caused by the effects of viscosity and surface tension on primary break-up, sheet disintegration, ligament and droplet formation. High speed imaging was used to capture the near-nozzle characteristics for water and drug formulations. This demonstrated more rapid atomization for lower viscosities. Image processing was used to analyze the near-nozzle spray characteristics during the primary break-up of the liquid sheet into ligament formation. Edges of the liquid sheet, spray break-up length, break-up radius, cone angle and dispersion angle were obtained. Spray characteristics pertinent for primary breakup modelling were determined from high speed imaging of multiple spray actuations. The results have established input data for computational modelling involving parametrical analysis of nasal drug delivery.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0236063</identifier><identifier>PMID: 32756567</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Atomization ; Atomizing ; Automotive engineering ; Biology and Life Sciences ; Breakup ; Computer applications ; Design and construction ; Design optimization ; Digital cameras ; Disintegration ; Drug delivery ; Drug delivery systems ; Engineering and Technology ; Engineering schools ; High speed ; Image processing ; Information processing ; Ligaments ; Liquid sheets ; Medicine and Health Sciences ; Methods ; Nasal sprays ; Nozzle geometry ; Nozzles ; Pharmacological research ; Physical Sciences ; Spray characteristics ; Surface tension ; Velocity ; Viscosity</subject><ispartof>PloS one, 2020-08, Vol.15 (8), p.e0236063-e0236063</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Shrestha et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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A secondary objective was to gain visualization and insight into the atomization break up mechanism caused by the effects of viscosity and surface tension on primary break-up, sheet disintegration, ligament and droplet formation. High speed imaging was used to capture the near-nozzle characteristics for water and drug formulations. This demonstrated more rapid atomization for lower viscosities. Image processing was used to analyze the near-nozzle spray characteristics during the primary break-up of the liquid sheet into ligament formation. Edges of the liquid sheet, spray break-up length, break-up radius, cone angle and dispersion angle were obtained. Spray characteristics pertinent for primary breakup modelling were determined from high speed imaging of multiple spray actuations. The results have established input data for computational modelling involving parametrical analysis of nasal drug delivery.</description><subject>Atomization</subject><subject>Atomizing</subject><subject>Automotive engineering</subject><subject>Biology and Life Sciences</subject><subject>Breakup</subject><subject>Computer applications</subject><subject>Design and construction</subject><subject>Design optimization</subject><subject>Digital cameras</subject><subject>Disintegration</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Engineering and Technology</subject><subject>Engineering schools</subject><subject>High speed</subject><subject>Image processing</subject><subject>Information processing</subject><subject>Ligaments</subject><subject>Liquid sheets</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Nasal sprays</subject><subject>Nozzle 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models. A secondary objective was to gain visualization and insight into the atomization break up mechanism caused by the effects of viscosity and surface tension on primary break-up, sheet disintegration, ligament and droplet formation. High speed imaging was used to capture the near-nozzle characteristics for water and drug formulations. This demonstrated more rapid atomization for lower viscosities. Image processing was used to analyze the near-nozzle spray characteristics during the primary break-up of the liquid sheet into ligament formation. Edges of the liquid sheet, spray break-up length, break-up radius, cone angle and dispersion angle were obtained. Spray characteristics pertinent for primary breakup modelling were determined from high speed imaging of multiple spray actuations. 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| subjects | Atomization Atomizing Automotive engineering Biology and Life Sciences Breakup Computer applications Design and construction Design optimization Digital cameras Disintegration Drug delivery Drug delivery systems Engineering and Technology Engineering schools High speed Image processing Information processing Ligaments Liquid sheets Medicine and Health Sciences Methods Nasal sprays Nozzle geometry Nozzles Pharmacological research Physical Sciences Spray characteristics Surface tension Velocity Viscosity |
| title | Primary break-up and atomization characteristics of a nasal spray |
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