Idiopathic intracranial hypertension in patients with anemia: A retrospective observational study
Idiopathic intracranial hypertension (IIH) mostly affects obese women in childbearing age, leading to frustrating headache and permanent visual impairment. The exact etiology of this condition is poorly understood, and the population at risk and clinical presentation seems to be homogeneous. However...
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| description | Idiopathic intracranial hypertension (IIH) mostly affects obese women in childbearing age, leading to frustrating headache and permanent visual impairment. The exact etiology of this condition is poorly understood, and the population at risk and clinical presentation seems to be homogeneous. However, little attention has been paid to the clinical features of IIH patients with anemia. We herein performed a retrospective observational study by using the data of patients with presumed IIH who were referred to the neurology department of Beijing Tongren Hospital from January 2014 to August 2019 to describe the clinical features and radiological findings in patients with IIH and anemia, and compared these with those without anemia. The patients were divided into two groups based on the presence of anemic diseases. Clinical data including demographic characteristics, clinical features, past medical history, laboratory and neuroradiological findings, diagnoses, treatments and prognosis of these patients were reviewed and compared in both the groups. A total of 153 patients with IIH were enrolled, which included 22 cases with anemia (mean age, 33.23±9.68 years; 19 [86.36%] female) and 131 cases without anemia (mean age 37.11±11.56 years; 97 [74.05%] female). In the anemia group, 19/22 cases had iron deficiency anemia and 3/22 had renal anemia. Compared with patients in the non-anemia group, IIH patients with anemia had a shorter disease course, and tended to present pulsatile tinnitus and transverse sinus stenosis (TSS), faster and better prognosis after treatments for correcting anemia and reducing intracranial pressure. Our findings highlighted the importance of obtaining full blood counts in IIH patients with subacute onset, and provided appropriate and prompt treatments if proven anemic in order to bring better outcomes. |
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The exact etiology of this condition is poorly understood, and the population at risk and clinical presentation seems to be homogeneous. However, little attention has been paid to the clinical features of IIH patients with anemia. We herein performed a retrospective observational study by using the data of patients with presumed IIH who were referred to the neurology department of Beijing Tongren Hospital from January 2014 to August 2019 to describe the clinical features and radiological findings in patients with IIH and anemia, and compared these with those without anemia. The patients were divided into two groups based on the presence of anemic diseases. Clinical data including demographic characteristics, clinical features, past medical history, laboratory and neuroradiological findings, diagnoses, treatments and prognosis of these patients were reviewed and compared in both the groups. A total of 153 patients with IIH were enrolled, which included 22 cases with anemia (mean age, 33.23±9.68 years; 19 [86.36%] female) and 131 cases without anemia (mean age 37.11±11.56 years; 97 [74.05%] female). In the anemia group, 19/22 cases had iron deficiency anemia and 3/22 had renal anemia. Compared with patients in the non-anemia group, IIH patients with anemia had a shorter disease course, and tended to present pulsatile tinnitus and transverse sinus stenosis (TSS), faster and better prognosis after treatments for correcting anemia and reducing intracranial pressure. Our findings highlighted the importance of obtaining full blood counts in IIH patients with subacute onset, and provided appropriate and prompt treatments if proven anemic in order to bring better outcomes.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0236828</identifier><identifier>PMID: 32735573</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Adults ; Age ; Anemia ; Antibodies ; Biology and Life Sciences ; Care and treatment ; Cerebrospinal fluid ; Deoxyribonucleic acid ; Development and progression ; Disease ; DNA ; Etiology ; Headache ; Headaches ; Hospitals ; Hypertension ; Intracranial hypertension ; Intracranial pressure ; Iron deficiency ; Laboratories ; Medical imaging ; Medical personnel ; Medicine and Health Sciences ; Mitochondrial DNA ; Neurology ; Nutrient deficiency ; Obesity ; Observational studies ; Overweight ; Patients ; Physiological aspects ; Prognosis ; Research and Analysis Methods ; Social Sciences ; Stenosis ; Studies ; Tinnitus ; Weight control</subject><ispartof>PloS one, 2020-07, Vol.15 (7), p.e0236828-e0236828</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Ma et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Ma et al 2020 Ma et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-dbf28fb5ff79df148f3dc9f2dd654834f1b3b77e84df2b5dc536413a01fb5cf33</citedby><cites>FETCH-LOGICAL-c669t-dbf28fb5ff79df148f3dc9f2dd654834f1b3b77e84df2b5dc536413a01fb5cf33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394431/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394431/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids></links><search><contributor>Barboza, Miguel A.</contributor><creatorcontrib>Ma, Zhonghua</creatorcontrib><creatorcontrib>Jiang, Hanqiu</creatorcontrib><creatorcontrib>Meng, Chao</creatorcontrib><creatorcontrib>Cui, Shilei</creatorcontrib><creatorcontrib>Peng, Jingting</creatorcontrib><creatorcontrib>Wang, Jiawei</creatorcontrib><creatorcontrib>Barboza, Miguel A</creatorcontrib><title>Idiopathic intracranial hypertension in patients with anemia: A retrospective observational study</title><title>PloS one</title><description>Idiopathic intracranial hypertension (IIH) mostly affects obese women in childbearing age, leading to frustrating headache and permanent visual impairment. The exact etiology of this condition is poorly understood, and the population at risk and clinical presentation seems to be homogeneous. However, little attention has been paid to the clinical features of IIH patients with anemia. We herein performed a retrospective observational study by using the data of patients with presumed IIH who were referred to the neurology department of Beijing Tongren Hospital from January 2014 to August 2019 to describe the clinical features and radiological findings in patients with IIH and anemia, and compared these with those without anemia. The patients were divided into two groups based on the presence of anemic diseases. Clinical data including demographic characteristics, clinical features, past medical history, laboratory and neuroradiological findings, diagnoses, treatments and prognosis of these patients were reviewed and compared in both the groups. A total of 153 patients with IIH were enrolled, which included 22 cases with anemia (mean age, 33.23±9.68 years; 19 [86.36%] female) and 131 cases without anemia (mean age 37.11±11.56 years; 97 [74.05%] female). In the anemia group, 19/22 cases had iron deficiency anemia and 3/22 had renal anemia. Compared with patients in the non-anemia group, IIH patients with anemia had a shorter disease course, and tended to present pulsatile tinnitus and transverse sinus stenosis (TSS), faster and better prognosis after treatments for correcting anemia and reducing intracranial pressure. Our findings highlighted the importance of obtaining full blood counts in IIH patients with subacute onset, and provided appropriate and prompt treatments if proven anemic in order to bring better outcomes.</description><subject>Adults</subject><subject>Age</subject><subject>Anemia</subject><subject>Antibodies</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Cerebrospinal fluid</subject><subject>Deoxyribonucleic acid</subject><subject>Development and progression</subject><subject>Disease</subject><subject>DNA</subject><subject>Etiology</subject><subject>Headache</subject><subject>Headaches</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Intracranial hypertension</subject><subject>Intracranial pressure</subject><subject>Iron deficiency</subject><subject>Laboratories</subject><subject>Medical imaging</subject><subject>Medical personnel</subject><subject>Medicine and Health Sciences</subject><subject>Mitochondrial DNA</subject><subject>Neurology</subject><subject>Nutrient deficiency</subject><subject>Obesity</subject><subject>Observational studies</subject><subject>Overweight</subject><subject>Patients</subject><subject>Physiological aspects</subject><subject>Prognosis</subject><subject>Research and Analysis Methods</subject><subject>Social Sciences</subject><subject>Stenosis</subject><subject>Studies</subject><subject>Tinnitus</subject><subject>Weight 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study</atitle><jtitle>PloS one</jtitle><date>2020-07-31</date><risdate>2020</risdate><volume>15</volume><issue>7</issue><spage>e0236828</spage><epage>e0236828</epage><pages>e0236828-e0236828</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Idiopathic intracranial hypertension (IIH) mostly affects obese women in childbearing age, leading to frustrating headache and permanent visual impairment. The exact etiology of this condition is poorly understood, and the population at risk and clinical presentation seems to be homogeneous. However, little attention has been paid to the clinical features of IIH patients with anemia. We herein performed a retrospective observational study by using the data of patients with presumed IIH who were referred to the neurology department of Beijing Tongren Hospital from January 2014 to August 2019 to describe the clinical features and radiological findings in patients with IIH and anemia, and compared these with those without anemia. The patients were divided into two groups based on the presence of anemic diseases. Clinical data including demographic characteristics, clinical features, past medical history, laboratory and neuroradiological findings, diagnoses, treatments and prognosis of these patients were reviewed and compared in both the groups. A total of 153 patients with IIH were enrolled, which included 22 cases with anemia (mean age, 33.23±9.68 years; 19 [86.36%] female) and 131 cases without anemia (mean age 37.11±11.56 years; 97 [74.05%] female). In the anemia group, 19/22 cases had iron deficiency anemia and 3/22 had renal anemia. Compared with patients in the non-anemia group, IIH patients with anemia had a shorter disease course, and tended to present pulsatile tinnitus and transverse sinus stenosis (TSS), faster and better prognosis after treatments for correcting anemia and reducing intracranial pressure. Our findings highlighted the importance of obtaining full blood counts in IIH patients with subacute onset, and provided appropriate and prompt treatments if proven anemic in order to bring better outcomes.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32735573</pmid><doi>10.1371/journal.pone.0236828</doi><tpages>e0236828</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adults Age Anemia Antibodies Biology and Life Sciences Care and treatment Cerebrospinal fluid Deoxyribonucleic acid Development and progression Disease DNA Etiology Headache Headaches Hospitals Hypertension Intracranial hypertension Intracranial pressure Iron deficiency Laboratories Medical imaging Medical personnel Medicine and Health Sciences Mitochondrial DNA Neurology Nutrient deficiency Obesity Observational studies Overweight Patients Physiological aspects Prognosis Research and Analysis Methods Social Sciences Stenosis Studies Tinnitus Weight control |
| title | Idiopathic intracranial hypertension in patients with anemia: A retrospective observational study |
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