Ethanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis
Background Periodontitis is a multifactorial inflammatory disease of tooth supporting tissues caused by oral biofilms, influenced by environmental and genetic factors, among others. Ethanol consumption has been considered a factor that enhances alveolar bone loss, especially in high doses. The prese...
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| creator | Frazão, Deborah Ribeiro Maia, Cristiane do Socorro Ferraz Chemelo, Victória dos Santos Monteiro, Deiweson Ferreira, Railson de Oliveira Bittencourt, Leonardo Oliveira Balbinot, Gabriela de Souza Collares, Fabrício Mezzomo Rösing, Cassiano Kuchenbecker Martins, Manoela Domingues Lima, Rafael Rodrigues |
| description | Background Periodontitis is a multifactorial inflammatory disease of tooth supporting tissues caused by oral biofilms, influenced by environmental and genetic factors, among others. Ethanol consumption has been considered a factor that enhances alveolar bone loss, especially in high doses. The present study aims to investigate the changes promoted by ethanol binge drinking per se or associated with ligature-induced periodontal breakdown on alveolar bone loss. Materials and methods Thirty-two Wistar rats were randomly allocated into four groups: control (C), ethanol (3g/kg/day; 3 days On-4 days Off protocol by gavage for 28 days, EtOH), experimental periodontitis (EP) and experimental periodontitis plus ethanol administration (EP+EtOH). On day 14th, periodontitis was induced by ligatures that were placed around the lower first molars. On day 28th, the animals were euthanized and mandibles were submitted to stereomicroscopy for exposed root area analysis and micro-computed tomography (micro-CT) for the evaluation of alveolar bone loss and microstructural parameters. Results The results revealed that ligature-induced alveolar bone loss is aggravated by ethanol binge drinking compared to controls (1.06 ± 0.10 vs 0.77 ± 0.04; p |
| doi_str_mv | 10.1371/journal.pone.0236161 |
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| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_2429056924</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_dd42fedbac2b4185aabd26f24a632f94</doaj_id><sourcerecordid>2429056924</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-f4cc49450b964aa0a30d4668d631d81a27503f4dbcce233eb79a3eaadb5501423</originalsourceid><addsrcrecordid>eNp1Uk1v1DAUjBCIlsI_QMIS5yz-irO5IKGqlEqVuMDZev5I6sW1t7azYi_8dpxuQPTAyU_vjWdGo2matwRvCOvJh12cUwC_2cdgN5gyQQR51pyTgdFWUMye_zOfNa9y3mHcsa0QL5szRnuGqRjOm19X5Q5C9Ei5MFlkkgs_6oTsz33Mc7IIxtHqkhH4g40eElJVDz3M4F05IggGwTQlOECx-XTzMWfkwkJhk7u3oYD3x9YFM2tr0LKMJobiisuvmxcj-GzfrO9F8_3z1bfLL-3t1-uby0-3re4wK-3IteYD77AaBAfAwLDhQmyNYMRsCdC-wkZulNaWMmZVPwCzAEZ1HSacsovm3Yl3X93JNbosKacD7sRAeUXcnBAmwk7uq3FIRxnBycdFTJOEVJz2VhrD6WiNAk0VJ9sOQBkqRspBMDoOC9fHVW1W99boGkEC_4T06SW4OznFg-zZQGknKsH7lSDFh9nm8h_L_ITSqUae7PhXgWC5dOTPL7l0RK4dYb8BeEO1IQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2429056924</pqid></control><display><type>article</type><title>Ethanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis</title><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Frazão, Deborah Ribeiro ; Maia, Cristiane do Socorro Ferraz ; Chemelo, Victória dos Santos ; Monteiro, Deiweson ; Ferreira, Railson de Oliveira ; Bittencourt, Leonardo Oliveira ; Balbinot, Gabriela de Souza ; Collares, Fabrício Mezzomo ; Rösing, Cassiano Kuchenbecker ; Martins, Manoela Domingues ; Lima, Rafael Rodrigues</creator><contributor>Damron, Timothy</contributor><creatorcontrib>Frazão, Deborah Ribeiro ; Maia, Cristiane do Socorro Ferraz ; Chemelo, Victória dos Santos ; Monteiro, Deiweson ; Ferreira, Railson de Oliveira ; Bittencourt, Leonardo Oliveira ; Balbinot, Gabriela de Souza ; Collares, Fabrício Mezzomo ; Rösing, Cassiano Kuchenbecker ; Martins, Manoela Domingues ; Lima, Rafael Rodrigues ; Damron, Timothy</creatorcontrib><description>Background Periodontitis is a multifactorial inflammatory disease of tooth supporting tissues caused by oral biofilms, influenced by environmental and genetic factors, among others. Ethanol consumption has been considered a factor that enhances alveolar bone loss, especially in high doses. The present study aims to investigate the changes promoted by ethanol binge drinking per se or associated with ligature-induced periodontal breakdown on alveolar bone loss. Materials and methods Thirty-two Wistar rats were randomly allocated into four groups: control (C), ethanol (3g/kg/day; 3 days On-4 days Off protocol by gavage for 28 days, EtOH), experimental periodontitis (EP) and experimental periodontitis plus ethanol administration (EP+EtOH). On day 14th, periodontitis was induced by ligatures that were placed around the lower first molars. On day 28th, the animals were euthanized and mandibles were submitted to stereomicroscopy for exposed root area analysis and micro-computed tomography (micro-CT) for the evaluation of alveolar bone loss and microstructural parameters. Results The results revealed that ligature-induced alveolar bone loss is aggravated by ethanol binge drinking compared to controls (1.06 ± 0.10 vs 0.77 ± 0.04; p<0.0001). In addition, binge drinking per se altered the alveolar bone quality and density demonstrating a reduction in trabecular thickness, trabecular number parameter and bone density percentual. Periodontal disorder plus ethanol binge drinking group also demonstrated reduction of the quality of bone measured by trabecular thickness. Conclusions In conclusion, intense and episodic ethanol intake decreased alveolar bone quality in all microstructural parameters analyzed which may be considered a modifying factor of periodontitis, intensifying the already installed disease.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0236161</identifier><identifier>PMID: 32730269</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Alcohol ; Alcohol use ; Alveolar bone ; Behavior ; Binge drinking ; Biofilms ; Biology ; Biology and Life Sciences ; Bone density ; Bone loss ; Cancellous bone ; Computed tomography ; Dentistry ; Diabetes ; Disease ; Drinking behavior ; Ethanol ; Genetic factors ; Gum disease ; Inflammatory diseases ; Laboratory animals ; Mandible ; Medicine and Health Sciences ; Molars ; Parameter modification ; Periodontitis ; Physical Sciences ; Research and Analysis Methods ; Stereomicroscopy ; Teeth ; Thickness</subject><ispartof>PloS one, 2020-07, Vol.15 (7), p.e0236161</ispartof><rights>2020 Frazão et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Frazão et al 2020 Frazão et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-f4cc49450b964aa0a30d4668d631d81a27503f4dbcce233eb79a3eaadb5501423</citedby><cites>FETCH-LOGICAL-c503t-f4cc49450b964aa0a30d4668d631d81a27503f4dbcce233eb79a3eaadb5501423</cites><orcidid>0000-0003-1486-4013</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392256/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392256/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids></links><search><contributor>Damron, Timothy</contributor><creatorcontrib>Frazão, Deborah Ribeiro</creatorcontrib><creatorcontrib>Maia, Cristiane do Socorro Ferraz</creatorcontrib><creatorcontrib>Chemelo, Victória dos Santos</creatorcontrib><creatorcontrib>Monteiro, Deiweson</creatorcontrib><creatorcontrib>Ferreira, Railson de Oliveira</creatorcontrib><creatorcontrib>Bittencourt, Leonardo Oliveira</creatorcontrib><creatorcontrib>Balbinot, Gabriela de Souza</creatorcontrib><creatorcontrib>Collares, Fabrício Mezzomo</creatorcontrib><creatorcontrib>Rösing, Cassiano Kuchenbecker</creatorcontrib><creatorcontrib>Martins, Manoela Domingues</creatorcontrib><creatorcontrib>Lima, Rafael Rodrigues</creatorcontrib><title>Ethanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis</title><title>PloS one</title><description>Background Periodontitis is a multifactorial inflammatory disease of tooth supporting tissues caused by oral biofilms, influenced by environmental and genetic factors, among others. Ethanol consumption has been considered a factor that enhances alveolar bone loss, especially in high doses. The present study aims to investigate the changes promoted by ethanol binge drinking per se or associated with ligature-induced periodontal breakdown on alveolar bone loss. Materials and methods Thirty-two Wistar rats were randomly allocated into four groups: control (C), ethanol (3g/kg/day; 3 days On-4 days Off protocol by gavage for 28 days, EtOH), experimental periodontitis (EP) and experimental periodontitis plus ethanol administration (EP+EtOH). On day 14th, periodontitis was induced by ligatures that were placed around the lower first molars. On day 28th, the animals were euthanized and mandibles were submitted to stereomicroscopy for exposed root area analysis and micro-computed tomography (micro-CT) for the evaluation of alveolar bone loss and microstructural parameters. Results The results revealed that ligature-induced alveolar bone loss is aggravated by ethanol binge drinking compared to controls (1.06 ± 0.10 vs 0.77 ± 0.04; p<0.0001). In addition, binge drinking per se altered the alveolar bone quality and density demonstrating a reduction in trabecular thickness, trabecular number parameter and bone density percentual. Periodontal disorder plus ethanol binge drinking group also demonstrated reduction of the quality of bone measured by trabecular thickness. Conclusions In conclusion, intense and episodic ethanol intake decreased alveolar bone quality in all microstructural parameters analyzed which may be considered a modifying factor of periodontitis, intensifying the already installed disease.</description><subject>Alcohol</subject><subject>Alcohol use</subject><subject>Alveolar bone</subject><subject>Behavior</subject><subject>Binge drinking</subject><subject>Biofilms</subject><subject>Biology</subject><subject>Biology and Life Sciences</subject><subject>Bone density</subject><subject>Bone loss</subject><subject>Cancellous bone</subject><subject>Computed tomography</subject><subject>Dentistry</subject><subject>Diabetes</subject><subject>Disease</subject><subject>Drinking behavior</subject><subject>Ethanol</subject><subject>Genetic factors</subject><subject>Gum disease</subject><subject>Inflammatory diseases</subject><subject>Laboratory animals</subject><subject>Mandible</subject><subject>Medicine and Health Sciences</subject><subject>Molars</subject><subject>Parameter modification</subject><subject>Periodontitis</subject><subject>Physical Sciences</subject><subject>Research and Analysis Methods</subject><subject>Stereomicroscopy</subject><subject>Teeth</subject><subject>Thickness</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNp1Uk1v1DAUjBCIlsI_QMIS5yz-irO5IKGqlEqVuMDZev5I6sW1t7azYi_8dpxuQPTAyU_vjWdGo2matwRvCOvJh12cUwC_2cdgN5gyQQR51pyTgdFWUMye_zOfNa9y3mHcsa0QL5szRnuGqRjOm19X5Q5C9Ei5MFlkkgs_6oTsz33Mc7IIxtHqkhH4g40eElJVDz3M4F05IggGwTQlOECx-XTzMWfkwkJhk7u3oYD3x9YFM2tr0LKMJobiisuvmxcj-GzfrO9F8_3z1bfLL-3t1-uby0-3re4wK-3IteYD77AaBAfAwLDhQmyNYMRsCdC-wkZulNaWMmZVPwCzAEZ1HSacsovm3Yl3X93JNbosKacD7sRAeUXcnBAmwk7uq3FIRxnBycdFTJOEVJz2VhrD6WiNAk0VJ9sOQBkqRspBMDoOC9fHVW1W99boGkEC_4T06SW4OznFg-zZQGknKsH7lSDFh9nm8h_L_ITSqUae7PhXgWC5dOTPL7l0RK4dYb8BeEO1IQ</recordid><startdate>20200730</startdate><enddate>20200730</enddate><creator>Frazão, 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binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis</title><author>Frazão, Deborah Ribeiro ; Maia, Cristiane do Socorro Ferraz ; Chemelo, Victória dos Santos ; Monteiro, Deiweson ; Ferreira, Railson de Oliveira ; Bittencourt, Leonardo Oliveira ; Balbinot, Gabriela de Souza ; Collares, Fabrício Mezzomo ; Rösing, Cassiano Kuchenbecker ; Martins, Manoela Domingues ; Lima, Rafael Rodrigues</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-f4cc49450b964aa0a30d4668d631d81a27503f4dbcce233eb79a3eaadb5501423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alcohol</topic><topic>Alcohol use</topic><topic>Alveolar bone</topic><topic>Behavior</topic><topic>Binge drinking</topic><topic>Biofilms</topic><topic>Biology</topic><topic>Biology and Life Sciences</topic><topic>Bone density</topic><topic>Bone loss</topic><topic>Cancellous bone</topic><topic>Computed tomography</topic><topic>Dentistry</topic><topic>Diabetes</topic><topic>Disease</topic><topic>Drinking behavior</topic><topic>Ethanol</topic><topic>Genetic factors</topic><topic>Gum disease</topic><topic>Inflammatory diseases</topic><topic>Laboratory animals</topic><topic>Mandible</topic><topic>Medicine and Health Sciences</topic><topic>Molars</topic><topic>Parameter modification</topic><topic>Periodontitis</topic><topic>Physical Sciences</topic><topic>Research and Analysis Methods</topic><topic>Stereomicroscopy</topic><topic>Teeth</topic><topic>Thickness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frazão, Deborah Ribeiro</creatorcontrib><creatorcontrib>Maia, Cristiane do Socorro Ferraz</creatorcontrib><creatorcontrib>Chemelo, Victória dos Santos</creatorcontrib><creatorcontrib>Monteiro, Deiweson</creatorcontrib><creatorcontrib>Ferreira, Railson de 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Oliveira</au><au>Balbinot, Gabriela de Souza</au><au>Collares, Fabrício Mezzomo</au><au>Rösing, Cassiano Kuchenbecker</au><au>Martins, Manoela Domingues</au><au>Lima, Rafael Rodrigues</au><au>Damron, Timothy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis</atitle><jtitle>PloS one</jtitle><date>2020-07-30</date><risdate>2020</risdate><volume>15</volume><issue>7</issue><spage>e0236161</spage><pages>e0236161-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Background Periodontitis is a multifactorial inflammatory disease of tooth supporting tissues caused by oral biofilms, influenced by environmental and genetic factors, among others. Ethanol consumption has been considered a factor that enhances alveolar bone loss, especially in high doses. The present study aims to investigate the changes promoted by ethanol binge drinking per se or associated with ligature-induced periodontal breakdown on alveolar bone loss. Materials and methods Thirty-two Wistar rats were randomly allocated into four groups: control (C), ethanol (3g/kg/day; 3 days On-4 days Off protocol by gavage for 28 days, EtOH), experimental periodontitis (EP) and experimental periodontitis plus ethanol administration (EP+EtOH). On day 14th, periodontitis was induced by ligatures that were placed around the lower first molars. On day 28th, the animals were euthanized and mandibles were submitted to stereomicroscopy for exposed root area analysis and micro-computed tomography (micro-CT) for the evaluation of alveolar bone loss and microstructural parameters. Results The results revealed that ligature-induced alveolar bone loss is aggravated by ethanol binge drinking compared to controls (1.06 ± 0.10 vs 0.77 ± 0.04; p<0.0001). In addition, binge drinking per se altered the alveolar bone quality and density demonstrating a reduction in trabecular thickness, trabecular number parameter and bone density percentual. Periodontal disorder plus ethanol binge drinking group also demonstrated reduction of the quality of bone measured by trabecular thickness. Conclusions In conclusion, intense and episodic ethanol intake decreased alveolar bone quality in all microstructural parameters analyzed which may be considered a modifying factor of periodontitis, intensifying the already installed disease.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32730269</pmid><doi>10.1371/journal.pone.0236161</doi><orcidid>https://orcid.org/0000-0003-1486-4013</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alcohol Alcohol use Alveolar bone Behavior Binge drinking Biofilms Biology Biology and Life Sciences Bone density Bone loss Cancellous bone Computed tomography Dentistry Diabetes Disease Drinking behavior Ethanol Genetic factors Gum disease Inflammatory diseases Laboratory animals Mandible Medicine and Health Sciences Molars Parameter modification Periodontitis Physical Sciences Research and Analysis Methods Stereomicroscopy Teeth Thickness |
| title | Ethanol binge drinking exposure affects alveolar bone quality and aggravates bone loss in experimentally-induced periodontitis |
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