The CaMKII K42M and K42R mutations are equivalent in suppressing kinase activity and targeting

CaMKII is an important mediator of forms of synaptic plasticity that are thought to underly learning and memory. The CaMKII mutants K42M and K42R have been used interchangeably as research tools, although some reported phenotypic differences suggest that they may differ in the extent to which they i...

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Veröffentlicht in:	PloS one 2020-07, Vol.15 (7), p.e0236478-e0236478
Hauptverfasser:	Tullis, Jonathan E, Rumian, Nicole L, Brown, Carolyn Nicole, Bayer, K Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Biology and Life Sciences Ca2+/calmodulin-dependent protein kinase II Calcium - metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 - chemistry Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics Calmodulin Cells, Cultured Female Gene mutation Genetic aspects Glutamic Acid - pharmacology HEK293 Cells Hippocampus - cytology Humans Kinases Localization Male Medicine and Health Sciences Movement Mutation Mutation - genetics Neurological research Neuroplasticity Neurosciences Pharmacology Phosphorylation Physiological aspects Plasticity (synaptic) Protein kinases Proteins Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - metabolism Synapses Synapses - metabolism Synaptic plasticity
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