Echocardiographic index E/e’ in association with cerebral white matter hyperintensity progression
Cerebral white-matter hyperintensities (WMHs) on MRI is associated with reduced compliance of the cerebral arterioles. We hypothesized that an echocardiography index for left ventricular (LV) diastolic function, E/e', might reflect the cerebral arteriolar compliance and evaluated the associatio...
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| description | Cerebral white-matter hyperintensities (WMHs) on MRI is associated with reduced compliance of the cerebral arterioles. We hypothesized that an echocardiography index for left ventricular (LV) diastolic function, E/e', might reflect the cerebral arteriolar compliance and evaluated the association between E/e' and long-term progression rate of the cerebral WMH volume. This retrospective study included individuals who were [greater than or equal to] 50 years of age, with a preserved LV ejection fraction ([greater than or equal to] 50%) and neurological function status (modified Rankin scale score [less than or equal to]1), and underwent initial and follow-up MRI evaluations within intervals of 34-45 months. Baseline clinical, laboratory, and echocardiography markers such as ejection fraction, LV mass index, and E/e' were obtained. WMH volume progression rate between the baseline and follow-up MRIs was designated as the outcome factor. 392 individuals (57.1% men; mean age: 66.7±8.4 years) were followed-up for 38.2±3.4 months. The mean WMH volume progression rate was 1.35±2.65 mL/year. The log-transformed value of WMH volume progression rate was linearly associated with the log-transformed E/e' (B coefficient = 0.365; 95% confidence interval [CI] 0.180-0.551; P = 0.001), along with the log-transformed values of baseline WMH volume (B = 0.142; 95% CI 0.106-0.179; P |
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We hypothesized that an echocardiography index for left ventricular (LV) diastolic function, E/e', might reflect the cerebral arteriolar compliance and evaluated the association between E/e' and long-term progression rate of the cerebral WMH volume. This retrospective study included individuals who were [greater than or equal to] 50 years of age, with a preserved LV ejection fraction ([greater than or equal to] 50%) and neurological function status (modified Rankin scale score [less than or equal to]1), and underwent initial and follow-up MRI evaluations within intervals of 34-45 months. Baseline clinical, laboratory, and echocardiography markers such as ejection fraction, LV mass index, and E/e' were obtained. WMH volume progression rate between the baseline and follow-up MRIs was designated as the outcome factor. 392 individuals (57.1% men; mean age: 66.7±8.4 years) were followed-up for 38.2±3.4 months. The mean WMH volume progression rate was 1.35±2.65 mL/year. The log-transformed value of WMH volume progression rate was linearly associated with the log-transformed E/e' (B coefficient = 0.365; 95% confidence interval [CI] 0.180-0.551; P = 0.001), along with the log-transformed values of baseline WMH volume (B = 0.142; 95% CI 0.106-0.179; P<0.001) and glomerular filtration rate (B = -0.182; 95% CI -0.321-0.044; P = 0.010). Additionally, a subgroup with an E/e' [greater than or equal to]15 exhibited a significantly higher WMH progression rate compared to the subgroups with lower E/e' values (P<0.001), especially in the lower quartiles (quartiles 1 and 2) of the baseline WMH volume. We concluded that echocardiographic marker E/e' is associated with the long-term progression rate of cerebral WMHs in population with preserved LV systolic function.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0236473</identifier><identifier>PMID: 32716979</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Arterioles ; Biology and Life Sciences ; Blood pressure ; Cardiac arrhythmia ; Cardiovascular disease ; Cerebral white matter ; Cerebrovascular disorders ; Confidence intervals ; Coronary vessels ; Development and progression ; Diagnosis ; Echocardiography ; Ejection fraction ; Glomerular filtration rate ; Health aspects ; Heart ; Heart attacks ; Left heart ventricle ; Magnetic resonance imaging ; Markers ; Medical imaging ; Medicine and Health Sciences ; Neurology ; Population ; Quartiles ; Research and Analysis Methods ; Stroke ; Subgroups ; Substantia alba ; Velocity ; Ventricle ; Volumetric analysis</subject><ispartof>PloS one, 2020-07, Vol.15 (7), p.e0236473-e0236473</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Lee et al 2020 Lee et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c630t-1633e38b56d5990b1a457d1d77874de821b75e560cd341357a0d9d1441c938e53</citedby><cites>FETCH-LOGICAL-c630t-1633e38b56d5990b1a457d1d77874de821b75e560cd341357a0d9d1441c938e53</cites><orcidid>0000-0003-1433-8005</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384642/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384642/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids></links><search><creatorcontrib>Lee, Woo-Jin</creatorcontrib><creatorcontrib>Jung, Keun-Hwa</creatorcontrib><creatorcontrib>Ryu, Young Jin</creatorcontrib><creatorcontrib>Lee, Soon-Tae</creatorcontrib><creatorcontrib>Park, Kyung-Il</creatorcontrib><creatorcontrib>Chu, Kon</creatorcontrib><creatorcontrib>Kim, Manho</creatorcontrib><creatorcontrib>Lee, Sang Kun</creatorcontrib><creatorcontrib>Roh, Jae-Kyu</creatorcontrib><title>Echocardiographic index E/e’ in association with cerebral white matter hyperintensity progression</title><title>PloS one</title><description>Cerebral white-matter hyperintensities (WMHs) on MRI is associated with reduced compliance of the cerebral arterioles. We hypothesized that an echocardiography index for left ventricular (LV) diastolic function, E/e', might reflect the cerebral arteriolar compliance and evaluated the association between E/e' and long-term progression rate of the cerebral WMH volume. This retrospective study included individuals who were [greater than or equal to] 50 years of age, with a preserved LV ejection fraction ([greater than or equal to] 50%) and neurological function status (modified Rankin scale score [less than or equal to]1), and underwent initial and follow-up MRI evaluations within intervals of 34-45 months. Baseline clinical, laboratory, and echocardiography markers such as ejection fraction, LV mass index, and E/e' were obtained. WMH volume progression rate between the baseline and follow-up MRIs was designated as the outcome factor. 392 individuals (57.1% men; mean age: 66.7±8.4 years) were followed-up for 38.2±3.4 months. The mean WMH volume progression rate was 1.35±2.65 mL/year. The log-transformed value of WMH volume progression rate was linearly associated with the log-transformed E/e' (B coefficient = 0.365; 95% confidence interval [CI] 0.180-0.551; P = 0.001), along with the log-transformed values of baseline WMH volume (B = 0.142; 95% CI 0.106-0.179; P<0.001) and glomerular filtration rate (B = -0.182; 95% CI -0.321-0.044; P = 0.010). Additionally, a subgroup with an E/e' [greater than or equal to]15 exhibited a significantly higher WMH progression rate compared to the subgroups with lower E/e' values (P<0.001), especially in the lower quartiles (quartiles 1 and 2) of the baseline WMH volume. We concluded that echocardiographic marker E/e' is associated with the long-term progression rate of cerebral WMHs in population with preserved LV systolic function.</description><subject>Arterioles</subject><subject>Biology and Life Sciences</subject><subject>Blood pressure</subject><subject>Cardiac arrhythmia</subject><subject>Cardiovascular disease</subject><subject>Cerebral white matter</subject><subject>Cerebrovascular disorders</subject><subject>Confidence intervals</subject><subject>Coronary vessels</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Echocardiography</subject><subject>Ejection fraction</subject><subject>Glomerular filtration rate</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Left heart ventricle</subject><subject>Magnetic resonance imaging</subject><subject>Markers</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Neurology</subject><subject>Population</subject><subject>Quartiles</subject><subject>Research and Analysis Methods</subject><subject>Stroke</subject><subject>Subgroups</subject><subject>Substantia alba</subject><subject>Velocity</subject><subject>Ventricle</subject><subject>Volumetric 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index E/e’ in association with cerebral white matter hyperintensity progression</title><author>Lee, Woo-Jin ; Jung, Keun-Hwa ; Ryu, Young Jin ; Lee, Soon-Tae ; Park, Kyung-Il ; Chu, Kon ; Kim, Manho ; Lee, Sang Kun ; Roh, Jae-Kyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c630t-1633e38b56d5990b1a457d1d77874de821b75e560cd341357a0d9d1441c938e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Arterioles</topic><topic>Biology and Life Sciences</topic><topic>Blood pressure</topic><topic>Cardiac arrhythmia</topic><topic>Cardiovascular disease</topic><topic>Cerebral white matter</topic><topic>Cerebrovascular disorders</topic><topic>Confidence intervals</topic><topic>Coronary vessels</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Echocardiography</topic><topic>Ejection fraction</topic><topic>Glomerular filtration rate</topic><topic>Health aspects</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Left heart ventricle</topic><topic>Magnetic resonance imaging</topic><topic>Markers</topic><topic>Medical imaging</topic><topic>Medicine and Health Sciences</topic><topic>Neurology</topic><topic>Population</topic><topic>Quartiles</topic><topic>Research and Analysis Methods</topic><topic>Stroke</topic><topic>Subgroups</topic><topic>Substantia alba</topic><topic>Velocity</topic><topic>Ventricle</topic><topic>Volumetric analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Woo-Jin</creatorcontrib><creatorcontrib>Jung, Keun-Hwa</creatorcontrib><creatorcontrib>Ryu, Young Jin</creatorcontrib><creatorcontrib>Lee, Soon-Tae</creatorcontrib><creatorcontrib>Park, Kyung-Il</creatorcontrib><creatorcontrib>Chu, Kon</creatorcontrib><creatorcontrib>Kim, Manho</creatorcontrib><creatorcontrib>Lee, Sang Kun</creatorcontrib><creatorcontrib>Roh, 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Keun-Hwa</au><au>Ryu, Young Jin</au><au>Lee, Soon-Tae</au><au>Park, Kyung-Il</au><au>Chu, Kon</au><au>Kim, Manho</au><au>Lee, Sang Kun</au><au>Roh, Jae-Kyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Echocardiographic index E/e’ in association with cerebral white matter hyperintensity progression</atitle><jtitle>PloS one</jtitle><date>2020-07-27</date><risdate>2020</risdate><volume>15</volume><issue>7</issue><spage>e0236473</spage><epage>e0236473</epage><pages>e0236473-e0236473</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Cerebral white-matter hyperintensities (WMHs) on MRI is associated with reduced compliance of the cerebral arterioles. We hypothesized that an echocardiography index for left ventricular (LV) diastolic function, E/e', might reflect the cerebral arteriolar compliance and evaluated the association between E/e' and long-term progression rate of the cerebral WMH volume. This retrospective study included individuals who were [greater than or equal to] 50 years of age, with a preserved LV ejection fraction ([greater than or equal to] 50%) and neurological function status (modified Rankin scale score [less than or equal to]1), and underwent initial and follow-up MRI evaluations within intervals of 34-45 months. Baseline clinical, laboratory, and echocardiography markers such as ejection fraction, LV mass index, and E/e' were obtained. WMH volume progression rate between the baseline and follow-up MRIs was designated as the outcome factor. 392 individuals (57.1% men; mean age: 66.7±8.4 years) were followed-up for 38.2±3.4 months. The mean WMH volume progression rate was 1.35±2.65 mL/year. The log-transformed value of WMH volume progression rate was linearly associated with the log-transformed E/e' (B coefficient = 0.365; 95% confidence interval [CI] 0.180-0.551; P = 0.001), along with the log-transformed values of baseline WMH volume (B = 0.142; 95% CI 0.106-0.179; P<0.001) and glomerular filtration rate (B = -0.182; 95% CI -0.321-0.044; P = 0.010). Additionally, a subgroup with an E/e' [greater than or equal to]15 exhibited a significantly higher WMH progression rate compared to the subgroups with lower E/e' values (P<0.001), especially in the lower quartiles (quartiles 1 and 2) of the baseline WMH volume. We concluded that echocardiographic marker E/e' is associated with the long-term progression rate of cerebral WMHs in population with preserved LV systolic function.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32716979</pmid><doi>10.1371/journal.pone.0236473</doi><tpages>e0236473</tpages><orcidid>https://orcid.org/0000-0003-1433-8005</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Arterioles Biology and Life Sciences Blood pressure Cardiac arrhythmia Cardiovascular disease Cerebral white matter Cerebrovascular disorders Confidence intervals Coronary vessels Development and progression Diagnosis Echocardiography Ejection fraction Glomerular filtration rate Health aspects Heart Heart attacks Left heart ventricle Magnetic resonance imaging Markers Medical imaging Medicine and Health Sciences Neurology Population Quartiles Research and Analysis Methods Stroke Subgroups Substantia alba Velocity Ventricle Volumetric analysis |
| title | Echocardiographic index E/e’ in association with cerebral white matter hyperintensity progression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T22%3A22%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Echocardiographic%20index%20E/e%E2%80%99%20in%20association%20with%20cerebral%20white%20matter%20hyperintensity%20progression&rft.jtitle=PloS%20one&rft.au=Lee,%20Woo-Jin&rft.date=2020-07-27&rft.volume=15&rft.issue=7&rft.spage=e0236473&rft.epage=e0236473&rft.pages=e0236473-e0236473&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0236473&rft_dat=%3Cgale_plos_%3EA630721841%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2427511094&rft_id=info:pmid/32716979&rft_galeid=A630721841&rft_doaj_id=oai_doaj_org_article_dd4c25c65e224db687f3fb8d107d4598&rfr_iscdi=true |