A voxel-based analysis of cerebral blood flow abnormalities in obsessive-compulsive disorder using pseudo-continuous arterial spin labeling MRI
To identify abnormalities of regional cerebral blood flow (rCBF) in individuals with obsessive-compulsive disorder (OCD) by conducting a voxel-based analysis of pseudo-continuous arterial spin labeling (pCASL) perfusion images. This prospective study included 23 OCD patients (nine males, 14 females;...
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| creator | Momosaka, Daichi Togao, Osamu Hiwatashi, Akio Yamashita, Koji Kikuchi, Kazufumi Tomiyama, Hirofumi Nakao, Tomohiro Murayama, Keitaro Suzuki, Yuriko Honda, Hiroshi Chen, Xi |
| description | To identify abnormalities of regional cerebral blood flow (rCBF) in individuals with obsessive-compulsive disorder (OCD) by conducting a voxel-based analysis of pseudo-continuous arterial spin labeling (pCASL) perfusion images. This prospective study included 23 OCD patients (nine males, 14 females; age 21-62 years; mean ± SD 37.2 ± 10.7 years) diagnosed based on DSM-IV-TR criteria and 64 healthy controls (27 males, 37 females; age 20-64 years; mean ± SD 38.3 ± 12.8 years). Subjects were recruited from October 2011 to August 2017. Imaging was performed on a 3T scanner. Quantitative rCBF maps generated from pCASL images were co-registered and resliced with the three-dimensional T1-weighted images, and then spatially normalized to a brain template and smoothed. We used statistical nonparametric mapping to assess the differences in rCBF and gray matter volume between the OCD and control groups. The significance level was set at the p-value |
| doi_str_mv | 10.1371/journal.pone.0236512 |
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This prospective study included 23 OCD patients (nine males, 14 females; age 21-62 years; mean ± SD 37.2 ± 10.7 years) diagnosed based on DSM-IV-TR criteria and 64 healthy controls (27 males, 37 females; age 20-64 years; mean ± SD 38.3 ± 12.8 years). Subjects were recruited from October 2011 to August 2017. Imaging was performed on a 3T scanner. Quantitative rCBF maps generated from pCASL images were co-registered and resliced with the three-dimensional T1-weighted images, and then spatially normalized to a brain template and smoothed. We used statistical nonparametric mapping to assess the differences in rCBF and gray matter volume between the OCD and control groups. The significance level was set at the p-value <0.05 with family-wise error rate correction for multiple comparisons. Compared to the control group, there were significant rCBF reductions in the right putamen, right frontal operculum, left midcingulate cortex, and right temporal pole in the OCD group. There were no significant between-group differences in the gray matter volume. The pCASL imaging noninvasively detected physiologically disrupted areas without structural abnormalities in OCD patients. The rCBF reductions observed in these regions in OCD patients could be associated with the pathophysiology of OCD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0236512</identifier><identifier>PMID: 32706796</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Abnormalities ; Biology and Life Sciences ; Blood ; Blood flow ; Brain ; Cerebral blood flow ; Cerebral circulation ; Cortex (frontal) ; Cortex (temporal) ; Error correction ; Females ; Health aspects ; Labeling ; Labelling ; Magnetic resonance imaging ; Males ; Mapping ; Medical imaging ; Medicine and Health Sciences ; Mental disorders ; Methods ; Neuroimaging ; Neuroses ; Obsessive compulsive disorder ; Operculum ; Patients ; Perfusion ; Physiological aspects ; Putamen ; Research and Analysis Methods ; Software ; Spin labeling ; Studies ; Substantia grisea ; Supervision ; Temporal lobe</subject><ispartof>PloS one, 2020-07, Vol.15 (7), p.e0236512-e0236512</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Momosaka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Momosaka et al 2020 Momosaka et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-d5a392f1995b3475023c5e9a5915e83544fa0ac2d13edb9102bc25bd358298e3</citedby><cites>FETCH-LOGICAL-c669t-d5a392f1995b3475023c5e9a5915e83544fa0ac2d13edb9102bc25bd358298e3</cites><orcidid>0000-0002-9846-8693</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380600/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380600/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids></links><search><creatorcontrib>Momosaka, Daichi</creatorcontrib><creatorcontrib>Togao, Osamu</creatorcontrib><creatorcontrib>Hiwatashi, Akio</creatorcontrib><creatorcontrib>Yamashita, Koji</creatorcontrib><creatorcontrib>Kikuchi, Kazufumi</creatorcontrib><creatorcontrib>Tomiyama, Hirofumi</creatorcontrib><creatorcontrib>Nakao, Tomohiro</creatorcontrib><creatorcontrib>Murayama, Keitaro</creatorcontrib><creatorcontrib>Suzuki, Yuriko</creatorcontrib><creatorcontrib>Honda, Hiroshi</creatorcontrib><creatorcontrib>Chen, Xi</creatorcontrib><title>A voxel-based analysis of cerebral blood flow abnormalities in obsessive-compulsive disorder using pseudo-continuous arterial spin labeling MRI</title><title>PloS one</title><description>To identify abnormalities of regional cerebral blood flow (rCBF) in individuals with obsessive-compulsive disorder (OCD) by conducting a voxel-based analysis of pseudo-continuous arterial spin labeling (pCASL) perfusion images. This prospective study included 23 OCD patients (nine males, 14 females; age 21-62 years; mean ± SD 37.2 ± 10.7 years) diagnosed based on DSM-IV-TR criteria and 64 healthy controls (27 males, 37 females; age 20-64 years; mean ± SD 38.3 ± 12.8 years). Subjects were recruited from October 2011 to August 2017. Imaging was performed on a 3T scanner. Quantitative rCBF maps generated from pCASL images were co-registered and resliced with the three-dimensional T1-weighted images, and then spatially normalized to a brain template and smoothed. We used statistical nonparametric mapping to assess the differences in rCBF and gray matter volume between the OCD and control groups. The significance level was set at the p-value <0.05 with family-wise error rate correction for multiple comparisons. Compared to the control group, there were significant rCBF reductions in the right putamen, right frontal operculum, left midcingulate cortex, and right temporal pole in the OCD group. There were no significant between-group differences in the gray matter volume. The pCASL imaging noninvasively detected physiologically disrupted areas without structural abnormalities in OCD patients. The rCBF reductions observed in these regions in OCD patients could be associated with the pathophysiology of OCD.</description><subject>Abnormalities</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood flow</subject><subject>Brain</subject><subject>Cerebral blood flow</subject><subject>Cerebral circulation</subject><subject>Cortex (frontal)</subject><subject>Cortex (temporal)</subject><subject>Error correction</subject><subject>Females</subject><subject>Health aspects</subject><subject>Labeling</subject><subject>Labelling</subject><subject>Magnetic resonance imaging</subject><subject>Males</subject><subject>Mapping</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Mental disorders</subject><subject>Methods</subject><subject>Neuroimaging</subject><subject>Neuroses</subject><subject>Obsessive compulsive 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Koji</au><au>Kikuchi, Kazufumi</au><au>Tomiyama, Hirofumi</au><au>Nakao, Tomohiro</au><au>Murayama, Keitaro</au><au>Suzuki, Yuriko</au><au>Honda, Hiroshi</au><au>Chen, Xi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A voxel-based analysis of cerebral blood flow abnormalities in obsessive-compulsive disorder using pseudo-continuous arterial spin labeling MRI</atitle><jtitle>PloS one</jtitle><date>2020-07-24</date><risdate>2020</risdate><volume>15</volume><issue>7</issue><spage>e0236512</spage><epage>e0236512</epage><pages>e0236512-e0236512</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To identify abnormalities of regional cerebral blood flow (rCBF) in individuals with obsessive-compulsive disorder (OCD) by conducting a voxel-based analysis of pseudo-continuous arterial spin labeling (pCASL) perfusion images. This prospective study included 23 OCD patients (nine males, 14 females; age 21-62 years; mean ± SD 37.2 ± 10.7 years) diagnosed based on DSM-IV-TR criteria and 64 healthy controls (27 males, 37 females; age 20-64 years; mean ± SD 38.3 ± 12.8 years). Subjects were recruited from October 2011 to August 2017. Imaging was performed on a 3T scanner. Quantitative rCBF maps generated from pCASL images were co-registered and resliced with the three-dimensional T1-weighted images, and then spatially normalized to a brain template and smoothed. We used statistical nonparametric mapping to assess the differences in rCBF and gray matter volume between the OCD and control groups. The significance level was set at the p-value <0.05 with family-wise error rate correction for multiple comparisons. Compared to the control group, there were significant rCBF reductions in the right putamen, right frontal operculum, left midcingulate cortex, and right temporal pole in the OCD group. There were no significant between-group differences in the gray matter volume. The pCASL imaging noninvasively detected physiologically disrupted areas without structural abnormalities in OCD patients. The rCBF reductions observed in these regions in OCD patients could be associated with the pathophysiology of OCD.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32706796</pmid><doi>10.1371/journal.pone.0236512</doi><tpages>e0236512</tpages><orcidid>https://orcid.org/0000-0002-9846-8693</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abnormalities Biology and Life Sciences Blood Blood flow Brain Cerebral blood flow Cerebral circulation Cortex (frontal) Cortex (temporal) Error correction Females Health aspects Labeling Labelling Magnetic resonance imaging Males Mapping Medical imaging Medicine and Health Sciences Mental disorders Methods Neuroimaging Neuroses Obsessive compulsive disorder Operculum Patients Perfusion Physiological aspects Putamen Research and Analysis Methods Software Spin labeling Studies Substantia grisea Supervision Temporal lobe |
| title | A voxel-based analysis of cerebral blood flow abnormalities in obsessive-compulsive disorder using pseudo-continuous arterial spin labeling MRI |
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