Synergistic effects of Cinnamomum cassia L. essential oil in combination with polymyxin B against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens
Multidrug resistance prompts the search for new sources of antibiotics with new targets at bacteria cell. To investigate the antibacterial activity of Cinnamomum cassia L. essential oil (CCeo) alone and in combination with antibiotics against carbapenemase-producing Klebsiella pneumoniae and Serrati...
Gespeichert in:
| Veröffentlicht in: | PloS one 2020-07, Vol.15 (7), p.e0236505-e0236505 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0236505 |
|---|---|
| container_issue | 7 |
| container_start_page | e0236505 |
| container_title | PloS one |
| container_volume | 15 |
| creator | Vasconcelos, Nathalie Gaebler Queiroz, Júlio Henrique Ferreira de Sá Silva, Késia Esther da Vasconcelos, Paulo César de Paula Croda, Julio Simionatto, Simone |
| description | Multidrug resistance prompts the search for new sources of antibiotics with new targets at bacteria cell. To investigate the antibacterial activity of Cinnamomum cassia L. essential oil (CCeo) alone and in combination with antibiotics against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens. The antimicrobial susceptibility of the strains was determined by Vitek® 2 and confirmed by MALDI-TOF/TOF. The antibacterial activity of CCeo and its synergism with antibiotics was determined using agar disk diffusion, broth microdilution, time-kill, and checkboard methods. The integrity of the bacterial cell membrane in S. marcescens was monitored by protein leakage assay. CCeo exhibited inhibitory effects with MIC = 281.25 μg.mL-1. The association between CCeo and polymyxin B showed a decrease in terms of viable cell counts on survival curves over time after a 4 hour-treatment with a FIC index value of 0.006. Protein leakage was observed with increasing concentrations for CCeo and CCeo + polymyxin B treatments. CCeo showed antibacterial activity against the studied strains. When associated with polymyxin B, a synergistic effect was able to inhibit bacterial growth rapidly and consistently, making it a potential candidate for the development of an alternative treatment and drug delivery system for carbapenemase-producing strains. |
| doi_str_mv | 10.1371/journal.pone.0236505 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_2426531668</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_ded19ef650f646c4a0ac48c708dd5ecb</doaj_id><sourcerecordid>2427309692</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-24e0d4366231736ea1cc4549ef3efef6576b53358f20f41d644e76b80512a7843</originalsourceid><addsrcrecordid>eNptUsuO1DAQjBCIXRb-AAlLXLjM4LeTCxKMeKxYicPC2eo4nVmPEjvYCTBfxG_i2RkQizjZ6q6uri5VVT1ldM2EYS93cUkBhvUUA64pF1pRda86Z43gK82puP_X_6x6lPOOUiVqrR9WZ4IbyhpDz6uf1_uAaevz7B3Bvkc3ZxJ7svEhwBjHZSQOcvZArtYEc8YwexhI9APxgbg4tj7A7GMg3_18Q6Y47Mf9j9J6Q2ALPuS5zKcWJgw4QsbVlGK3OB-25OOAbfY4DECmgMsYgwckEDpyjSkVUiAjJIfZYciPqwc9DBmfnN6L6su7t583H1ZXn95fbl5frZyiYl5xibSTQmsumBEagTknlWywF9hjr5XRrRJC1T2nvWSdlhJLqaaKcTC1FBfVsyPvNMRsTx5nyyXXSjCt64K4PCK6CDs7JV9E7m0Eb28LMW0tpOLmgLbDjjWHrbTXUjsJFJysnaF11yl0beF6ddq2tCN25dA5wXCH9G4n-Bu7jd-sEcZIzQrBixNBil8XzLMdffGreBowLre6jaCNbniBPv8H-v_r5BHlUsw5Yf9HDKP2kLvfU_aQO3vKnfgFRp_Qvg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2426531668</pqid></control><display><type>article</type><title>Synergistic effects of Cinnamomum cassia L. essential oil in combination with polymyxin B against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens</title><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Vasconcelos, Nathalie Gaebler ; Queiroz, Júlio Henrique Ferreira de Sá ; Silva, Késia Esther da ; Vasconcelos, Paulo César de Paula ; Croda, Julio ; Simionatto, Simone</creator><contributor>Koppisch, Andrew T.</contributor><creatorcontrib>Vasconcelos, Nathalie Gaebler ; Queiroz, Júlio Henrique Ferreira de Sá ; Silva, Késia Esther da ; Vasconcelos, Paulo César de Paula ; Croda, Julio ; Simionatto, Simone ; Koppisch, Andrew T.</creatorcontrib><description>Multidrug resistance prompts the search for new sources of antibiotics with new targets at bacteria cell. To investigate the antibacterial activity of Cinnamomum cassia L. essential oil (CCeo) alone and in combination with antibiotics against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens. The antimicrobial susceptibility of the strains was determined by Vitek® 2 and confirmed by MALDI-TOF/TOF. The antibacterial activity of CCeo and its synergism with antibiotics was determined using agar disk diffusion, broth microdilution, time-kill, and checkboard methods. The integrity of the bacterial cell membrane in S. marcescens was monitored by protein leakage assay. CCeo exhibited inhibitory effects with MIC = 281.25 μg.mL-1. The association between CCeo and polymyxin B showed a decrease in terms of viable cell counts on survival curves over time after a 4 hour-treatment with a FIC index value of 0.006. Protein leakage was observed with increasing concentrations for CCeo and CCeo + polymyxin B treatments. CCeo showed antibacterial activity against the studied strains. When associated with polymyxin B, a synergistic effect was able to inhibit bacterial growth rapidly and consistently, making it a potential candidate for the development of an alternative treatment and drug delivery system for carbapenemase-producing strains.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0236505</identifier><identifier>PMID: 32701970</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Antibacterial activity ; Antibiotics ; Antimicrobial agents ; Bacteria ; Biology and Life Sciences ; Carbapenemase ; Cell membranes ; Cell survival ; Cinnamomum cassia ; Deoxyribonucleic acid ; DNA ; Drug delivery ; Drug delivery systems ; Essential oils ; Infections ; Klebsiella ; Klebsiella pneumoniae ; Leakage ; Medicine and Health Sciences ; Minimum inhibitory concentration ; Multidrug resistance ; Oils & fats ; Polymyxin B ; Proteins ; Research and Analysis Methods ; Serratia marcescens ; Strains (organisms) ; Synergism ; Synergistic effect ; Synergistic effects</subject><ispartof>PloS one, 2020-07, Vol.15 (7), p.e0236505-e0236505</ispartof><rights>2020 Vasconcelos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Vasconcelos et al 2020 Vasconcelos et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-24e0d4366231736ea1cc4549ef3efef6576b53358f20f41d644e76b80512a7843</citedby><cites>FETCH-LOGICAL-c503t-24e0d4366231736ea1cc4549ef3efef6576b53358f20f41d644e76b80512a7843</cites><orcidid>0000-0003-2367-0915</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377461/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377461/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids></links><search><contributor>Koppisch, Andrew T.</contributor><creatorcontrib>Vasconcelos, Nathalie Gaebler</creatorcontrib><creatorcontrib>Queiroz, Júlio Henrique Ferreira de Sá</creatorcontrib><creatorcontrib>Silva, Késia Esther da</creatorcontrib><creatorcontrib>Vasconcelos, Paulo César de Paula</creatorcontrib><creatorcontrib>Croda, Julio</creatorcontrib><creatorcontrib>Simionatto, Simone</creatorcontrib><title>Synergistic effects of Cinnamomum cassia L. essential oil in combination with polymyxin B against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens</title><title>PloS one</title><description>Multidrug resistance prompts the search for new sources of antibiotics with new targets at bacteria cell. To investigate the antibacterial activity of Cinnamomum cassia L. essential oil (CCeo) alone and in combination with antibiotics against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens. The antimicrobial susceptibility of the strains was determined by Vitek® 2 and confirmed by MALDI-TOF/TOF. The antibacterial activity of CCeo and its synergism with antibiotics was determined using agar disk diffusion, broth microdilution, time-kill, and checkboard methods. The integrity of the bacterial cell membrane in S. marcescens was monitored by protein leakage assay. CCeo exhibited inhibitory effects with MIC = 281.25 μg.mL-1. The association between CCeo and polymyxin B showed a decrease in terms of viable cell counts on survival curves over time after a 4 hour-treatment with a FIC index value of 0.006. Protein leakage was observed with increasing concentrations for CCeo and CCeo + polymyxin B treatments. CCeo showed antibacterial activity against the studied strains. When associated with polymyxin B, a synergistic effect was able to inhibit bacterial growth rapidly and consistently, making it a potential candidate for the development of an alternative treatment and drug delivery system for carbapenemase-producing strains.</description><subject>Antibacterial activity</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Bacteria</subject><subject>Biology and Life Sciences</subject><subject>Carbapenemase</subject><subject>Cell membranes</subject><subject>Cell survival</subject><subject>Cinnamomum cassia</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Essential oils</subject><subject>Infections</subject><subject>Klebsiella</subject><subject>Klebsiella pneumoniae</subject><subject>Leakage</subject><subject>Medicine and Health Sciences</subject><subject>Minimum inhibitory concentration</subject><subject>Multidrug resistance</subject><subject>Oils & fats</subject><subject>Polymyxin B</subject><subject>Proteins</subject><subject>Research and Analysis Methods</subject><subject>Serratia marcescens</subject><subject>Strains (organisms)</subject><subject>Synergism</subject><subject>Synergistic effect</subject><subject>Synergistic effects</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUsuO1DAQjBCIXRb-AAlLXLjM4LeTCxKMeKxYicPC2eo4nVmPEjvYCTBfxG_i2RkQizjZ6q6uri5VVT1ldM2EYS93cUkBhvUUA64pF1pRda86Z43gK82puP_X_6x6lPOOUiVqrR9WZ4IbyhpDz6uf1_uAaevz7B3Bvkc3ZxJ7svEhwBjHZSQOcvZArtYEc8YwexhI9APxgbg4tj7A7GMg3_18Q6Y47Mf9j9J6Q2ALPuS5zKcWJgw4QsbVlGK3OB-25OOAbfY4DECmgMsYgwckEDpyjSkVUiAjJIfZYciPqwc9DBmfnN6L6su7t583H1ZXn95fbl5frZyiYl5xibSTQmsumBEagTknlWywF9hjr5XRrRJC1T2nvWSdlhJLqaaKcTC1FBfVsyPvNMRsTx5nyyXXSjCt64K4PCK6CDs7JV9E7m0Eb28LMW0tpOLmgLbDjjWHrbTXUjsJFJysnaF11yl0beF6ddq2tCN25dA5wXCH9G4n-Bu7jd-sEcZIzQrBixNBil8XzLMdffGreBowLre6jaCNbniBPv8H-v_r5BHlUsw5Yf9HDKP2kLvfU_aQO3vKnfgFRp_Qvg</recordid><startdate>20200723</startdate><enddate>20200723</enddate><creator>Vasconcelos, Nathalie Gaebler</creator><creator>Queiroz, Júlio Henrique Ferreira de Sá</creator><creator>Silva, Késia Esther da</creator><creator>Vasconcelos, Paulo César de Paula</creator><creator>Croda, Julio</creator><creator>Simionatto, Simone</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2367-0915</orcidid></search><sort><creationdate>20200723</creationdate><title>Synergistic effects of Cinnamomum cassia L. essential oil in combination with polymyxin B against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens</title><author>Vasconcelos, Nathalie Gaebler ; Queiroz, Júlio Henrique Ferreira de Sá ; Silva, Késia Esther da ; Vasconcelos, Paulo César de Paula ; Croda, Julio ; Simionatto, Simone</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-24e0d4366231736ea1cc4549ef3efef6576b53358f20f41d644e76b80512a7843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibacterial activity</topic><topic>Antibiotics</topic><topic>Antimicrobial agents</topic><topic>Bacteria</topic><topic>Biology and Life Sciences</topic><topic>Carbapenemase</topic><topic>Cell membranes</topic><topic>Cell survival</topic><topic>Cinnamomum cassia</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Essential oils</topic><topic>Infections</topic><topic>Klebsiella</topic><topic>Klebsiella pneumoniae</topic><topic>Leakage</topic><topic>Medicine and Health Sciences</topic><topic>Minimum inhibitory concentration</topic><topic>Multidrug resistance</topic><topic>Oils & fats</topic><topic>Polymyxin B</topic><topic>Proteins</topic><topic>Research and Analysis Methods</topic><topic>Serratia marcescens</topic><topic>Strains (organisms)</topic><topic>Synergism</topic><topic>Synergistic effect</topic><topic>Synergistic effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vasconcelos, Nathalie Gaebler</creatorcontrib><creatorcontrib>Queiroz, Júlio Henrique Ferreira de Sá</creatorcontrib><creatorcontrib>Silva, Késia Esther da</creatorcontrib><creatorcontrib>Vasconcelos, Paulo César de Paula</creatorcontrib><creatorcontrib>Croda, Julio</creatorcontrib><creatorcontrib>Simionatto, Simone</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vasconcelos, Nathalie Gaebler</au><au>Queiroz, Júlio Henrique Ferreira de Sá</au><au>Silva, Késia Esther da</au><au>Vasconcelos, Paulo César de Paula</au><au>Croda, Julio</au><au>Simionatto, Simone</au><au>Koppisch, Andrew T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synergistic effects of Cinnamomum cassia L. essential oil in combination with polymyxin B against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens</atitle><jtitle>PloS one</jtitle><date>2020-07-23</date><risdate>2020</risdate><volume>15</volume><issue>7</issue><spage>e0236505</spage><epage>e0236505</epage><pages>e0236505-e0236505</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Multidrug resistance prompts the search for new sources of antibiotics with new targets at bacteria cell. To investigate the antibacterial activity of Cinnamomum cassia L. essential oil (CCeo) alone and in combination with antibiotics against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens. The antimicrobial susceptibility of the strains was determined by Vitek® 2 and confirmed by MALDI-TOF/TOF. The antibacterial activity of CCeo and its synergism with antibiotics was determined using agar disk diffusion, broth microdilution, time-kill, and checkboard methods. The integrity of the bacterial cell membrane in S. marcescens was monitored by protein leakage assay. CCeo exhibited inhibitory effects with MIC = 281.25 μg.mL-1. The association between CCeo and polymyxin B showed a decrease in terms of viable cell counts on survival curves over time after a 4 hour-treatment with a FIC index value of 0.006. Protein leakage was observed with increasing concentrations for CCeo and CCeo + polymyxin B treatments. CCeo showed antibacterial activity against the studied strains. When associated with polymyxin B, a synergistic effect was able to inhibit bacterial growth rapidly and consistently, making it a potential candidate for the development of an alternative treatment and drug delivery system for carbapenemase-producing strains.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32701970</pmid><doi>10.1371/journal.pone.0236505</doi><orcidid>https://orcid.org/0000-0003-2367-0915</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-07, Vol.15 (7), p.e0236505-e0236505 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2426531668 |
| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Antibacterial activity Antibiotics Antimicrobial agents Bacteria Biology and Life Sciences Carbapenemase Cell membranes Cell survival Cinnamomum cassia Deoxyribonucleic acid DNA Drug delivery Drug delivery systems Essential oils Infections Klebsiella Klebsiella pneumoniae Leakage Medicine and Health Sciences Minimum inhibitory concentration Multidrug resistance Oils & fats Polymyxin B Proteins Research and Analysis Methods Serratia marcescens Strains (organisms) Synergism Synergistic effect Synergistic effects |
| title | Synergistic effects of Cinnamomum cassia L. essential oil in combination with polymyxin B against carbapenemase-producing Klebsiella pneumoniae and Serratia marcescens |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T12%3A25%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synergistic%20effects%20of%20Cinnamomum%20cassia%20L.%20essential%20oil%20in%20combination%20with%20polymyxin%20B%20against%20carbapenemase-producing%20Klebsiella%20pneumoniae%20and%20Serratia%20marcescens&rft.jtitle=PloS%20one&rft.au=Vasconcelos,%20Nathalie%20Gaebler&rft.date=2020-07-23&rft.volume=15&rft.issue=7&rft.spage=e0236505&rft.epage=e0236505&rft.pages=e0236505-e0236505&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0236505&rft_dat=%3Cproquest_plos_%3E2427309692%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2426531668&rft_id=info:pmid/32701970&rft_doaj_id=oai_doaj_org_article_ded19ef650f646c4a0ac48c708dd5ecb&rfr_iscdi=true |