Intranasal delivery of Thyroid hormones in MCT8 deficiency

Loss of function mutations in the gene encoding the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) lead to severe neurodevelopmental defects in humans associated with a specific thyroid hormone phenotype manifesting high serum 3,5,3'-triiodothyronine (T3) and low thyroxine (T4...

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Veröffentlicht in:	PloS one 2020-07, Vol.15 (7), p.e0236113-e0236113
Hauptverfasser:	Grijota-Martínez, Carmen, Bárez-López, Soledad, Ausó, Eva, Refetoff, Samuel, Frey, 2nd, William H, Guadaño-Ferraz, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animal models Animals Biology and Life Sciences Biomedical research Brain Brain - cytology Brain research Defects Drugs Gene expression Health aspects Hormones Hyperthyroidism Hypothyroidism Intranasal administration Medicine and Health Sciences Mice Monocarboxylic Acid Transporters - deficiency Monocarboxylic Acid Transporters - genetics Mutation Phenotypes Research and Analysis Methods Signal Transduction - drug effects Symporters - deficiency Symporters - genetics Thyroid Thyroid gland Thyroid hormones Thyroid Hormones - administration & dosage Thyroid Hormones - blood Thyroid Hormones - pharmacology Thyroxine Triiodothyronine
Online-Zugang:	Volltext
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